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Volumn 267, Issue 1-3, 2010, Pages 14-19

Working in partnership to advance the 3Rs in toxicity testing

Author keywords

3Rs; Acute toxicity; Monoclonal antibodies; Primates; Safety testing; Toxicokinetics

Indexed keywords

CHEMICAL COMPOUND; MONOCLONAL ANTIBODY;

EID: 71949116166     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.11.006     Document Type: Review
Times cited : (52)

References (32)
  • 2
    • 0025773702 scopus 로고
    • Why modification of the LD50 test will not be enough
    • Balls M. Why modification of the LD50 test will not be enough. Lab Anim. 25 (1991) 198-206
    • (1991) Lab Anim. , vol.25 , pp. 198-206
    • Balls, M.1
  • 4
    • 0030803485 scopus 로고    scopus 로고
    • Predictive testing in contact dermatitis. Irritant dermatitis
    • Basketter D.A., Reynolds F.S., and York M. Predictive testing in contact dermatitis. Irritant dermatitis. Clin. Dermatol. 15 (1997) 637-644
    • (1997) Clin. Dermatol. , vol.15 , pp. 637-644
    • Basketter, D.A.1    Reynolds, F.S.2    York, M.3
  • 5
    • 77949264704 scopus 로고    scopus 로고
    • Chapman, K., Pullen, N., Coney, L., Dempster, M., Andrews, L., Bajramovich, J., Baldrick, P., Buckley, L., Jacobs, A., Hale, G., Green, C., Ragan, I., Robinson, V., 2009. Preclinical development of monoclonal antibodies: considerations for the use of nonhuman primates. mAbs. 1, 505-516.
    • Chapman, K., Pullen, N., Coney, L., Dempster, M., Andrews, L., Bajramovich, J., Baldrick, P., Buckley, L., Jacobs, A., Hale, G., Green, C., Ragan, I., Robinson, V., 2009. Preclinical development of monoclonal antibodies: considerations for the use of nonhuman primates. mAbs. 1, 505-516.
  • 6
    • 33947587491 scopus 로고    scopus 로고
    • Preclinical safety testing of monoclonal antibodies: the significance of species relevance
    • Chapman K., Pullen N., Graham M., and Ragan I. Preclinical safety testing of monoclonal antibodies: the significance of species relevance. Nat. Rev. Drug Discov. 6 (2007) 120-126
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 120-126
    • Chapman, K.1    Pullen, N.2    Graham, M.3    Ragan, I.4
  • 9
    • 0142177156 scopus 로고    scopus 로고
    • Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products'. European Commission
    • EC. Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products'. European Commission. Off. J. Eur. Union L66 (2003) 26-35
    • (2003) Off. J. Eur. Union , vol.L66 , pp. 26-35
    • EC1
  • 10
    • 51849127476 scopus 로고    scopus 로고
    • Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restrictions of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives
    • EC. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restrictions of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Off. J. Eur. Union L396 (2006) 1-849
    • (2006) Off. J. Eur. Union , vol.L396 , pp. 1-849
    • EC1
  • 13
    • 0036972762 scopus 로고    scopus 로고
    • ECVAM's activities in validating alternative tests for skin corrosion and irritation
    • Fentem J.H., and Botham P.A. ECVAM's activities in validating alternative tests for skin corrosion and irritation. Altern. Lab Anim. 30 Suppl 2 (2002) 61-67
    • (2002) Altern. Lab Anim. , vol.30 , Issue.SUPPL. 2 , pp. 61-67
    • Fentem, J.H.1    Botham, P.A.2
  • 14
    • 69349104947 scopus 로고    scopus 로고
    • Chemical regulators have overreached
    • Hartung T., and Rovida C. Chemical regulators have overreached. Nature 460 (2009) 1080-1081
    • (2009) Nature , vol.460 , pp. 1080-1081
    • Hartung, T.1    Rovida, C.2
  • 15
    • 70349764058 scopus 로고    scopus 로고
    • Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing
    • Holmes A.M., Brown R., and Shakesheff K. Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing. Regen. Med. 4 (2009) 579-592
    • (2009) Regen. Med. , vol.4 , pp. 579-592
    • Holmes, A.M.1    Brown, R.2    Shakesheff, K.3
  • 19
    • 58149107977 scopus 로고    scopus 로고
    • Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay
    • Jagger C., Tate M., Cahill P.A., Hughes C., Knight A.W., Billinton N., and Walmsley R.M. Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay. Mutagenesis 24 (2009) 35-50
    • (2009) Mutagenesis , vol.24 , pp. 35-50
    • Jagger, C.1    Tate, M.2    Cahill, P.A.3    Hughes, C.4    Knight, A.W.5    Billinton, N.6    Walmsley, R.M.7
  • 21
    • 57349116822 scopus 로고    scopus 로고
    • Application of a systems biology approach for skin allergy risk assessment
    • Maxwell G., and Mackay C. Application of a systems biology approach for skin allergy risk assessment. AATEX 14 (2008) 381-388
    • (2008) AATEX , vol.14 , pp. 381-388
    • Maxwell, G.1    Mackay, C.2
  • 22
    • 85054111147 scopus 로고    scopus 로고
    • NC3Rs, 2007. Challenging the regulatory requirement for acute toxicity studies in the development of new medicines: a workshop report
    • NC3Rs, 2007. Challenging the regulatory requirement for acute toxicity studies in the development of new medicines: a workshop report. http://www.nc3rs.org.uk/downloaddoc.asp?id=559&page=22&skin=0.
  • 23
    • 85054107539 scopus 로고    scopus 로고
    • NC3Rs, 2009a. Animals in the chemical industry
    • NC3Rs, 2009a. Animals in the chemical industry. www.nc3rs.org.uk/chemicals.
  • 24
    • 85054115847 scopus 로고    scopus 로고
    • NC3Rs, 2009b. Encouraging commercialisation of tissue engineering-a speed-networking event
    • NC3Rs, 2009b. Encouraging commercialisation of tissue engineering-a speed-networking event. www.nc3rs.org.uk/speednetworking.
  • 25
    • 85054115299 scopus 로고    scopus 로고
    • NC3Rs, 2009c. Funded small awards
    • NC3Rs, 2009c. Funded small awards. www.nc3rs.org.uk/page.asp?id=290.
  • 27
    • 0036226331 scopus 로고    scopus 로고
    • Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products
    • Robinson M.K., Cohen C., De Fraissinette Ade B., Ponec M., Whittle E., and Fentem J.H. Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products. Food Chem. Toxicol. 40 (2002) 573-592
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 573-592
    • Robinson, M.K.1    Cohen, C.2    De Fraissinette Ade, B.3    Ponec, M.4    Whittle, E.5    Fentem, J.H.6
  • 28
    • 69249231966 scopus 로고    scopus 로고
    • Are acute toxicity studies required to support overdose for new medicines?
    • Robinson S., and Chapman K. Are acute toxicity studies required to support overdose for new medicines?. Regul. Toxicol. Pharmacol. 55 (2009) 110
    • (2009) Regul. Toxicol. Pharmacol. , vol.55 , pp. 110
    • Robinson, S.1    Chapman, K.2
  • 31
    • 67649400889 scopus 로고    scopus 로고
    • Assuring consumer safety without animals: applications for tissue engineering
    • Westmoreland C., and Holmes A.M. Assuring consumer safety without animals: applications for tissue engineering. Organogenesis 5 (2009) 67-72
    • (2009) Organogenesis , vol.5 , pp. 67-72
    • Westmoreland, C.1    Holmes, A.M.2
  • 32
    • 67650624126 scopus 로고    scopus 로고
    • An investigation into corneal alkali burns using an organ culture model
    • Zhao B., Ma A., Martin F.L., and Fullwood N.J. An investigation into corneal alkali burns using an organ culture model. Cornea 28 (2009) 541-546
    • (2009) Cornea , vol.28 , pp. 541-546
    • Zhao, B.1    Ma, A.2    Martin, F.L.3    Fullwood, N.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.