-
2
-
-
0025773702
-
Why modification of the LD50 test will not be enough
-
Balls M. Why modification of the LD50 test will not be enough. Lab Anim. 25 (1991) 198-206
-
(1991)
Lab Anim.
, vol.25
, pp. 198-206
-
-
Balls, M.1
-
3
-
-
33644867772
-
The acquisition and application of absorption, distribution, metabolism, and excretion (ADME) data in agricultural chemical safety assessments
-
Barton H.A., Pastoor T.P., Baetcke K., Chambers J.E., Diliberto J., Doerrer N.G., Driver J.H., Hastings C.E., Iyengar S., Krieger R., Stahl B., and Timchalk C. The acquisition and application of absorption, distribution, metabolism, and excretion (ADME) data in agricultural chemical safety assessments. Crit. Rev. Toxicol. 36 (2006) 9-35
-
(2006)
Crit. Rev. Toxicol.
, vol.36
, pp. 9-35
-
-
Barton, H.A.1
Pastoor, T.P.2
Baetcke, K.3
Chambers, J.E.4
Diliberto, J.5
Doerrer, N.G.6
Driver, J.H.7
Hastings, C.E.8
Iyengar, S.9
Krieger, R.10
Stahl, B.11
Timchalk, C.12
-
4
-
-
0030803485
-
Predictive testing in contact dermatitis. Irritant dermatitis
-
Basketter D.A., Reynolds F.S., and York M. Predictive testing in contact dermatitis. Irritant dermatitis. Clin. Dermatol. 15 (1997) 637-644
-
(1997)
Clin. Dermatol.
, vol.15
, pp. 637-644
-
-
Basketter, D.A.1
Reynolds, F.S.2
York, M.3
-
5
-
-
77949264704
-
-
Chapman, K., Pullen, N., Coney, L., Dempster, M., Andrews, L., Bajramovich, J., Baldrick, P., Buckley, L., Jacobs, A., Hale, G., Green, C., Ragan, I., Robinson, V., 2009. Preclinical development of monoclonal antibodies: considerations for the use of nonhuman primates. mAbs. 1, 505-516.
-
Chapman, K., Pullen, N., Coney, L., Dempster, M., Andrews, L., Bajramovich, J., Baldrick, P., Buckley, L., Jacobs, A., Hale, G., Green, C., Ragan, I., Robinson, V., 2009. Preclinical development of monoclonal antibodies: considerations for the use of nonhuman primates. mAbs. 1, 505-516.
-
-
-
-
6
-
-
33947587491
-
Preclinical safety testing of monoclonal antibodies: the significance of species relevance
-
Chapman K., Pullen N., Graham M., and Ragan I. Preclinical safety testing of monoclonal antibodies: the significance of species relevance. Nat. Rev. Drug Discov. 6 (2007) 120-126
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 120-126
-
-
Chapman, K.1
Pullen, N.2
Graham, M.3
Ragan, I.4
-
7
-
-
70350769111
-
Application of toxicokinetics to improve chemical risk assessment: implications for the use of animals
-
Creton S., Billington R., Davies W., Dent M., Hawksworth G., Parry S., and Travis K. Application of toxicokinetics to improve chemical risk assessment: implications for the use of animals. Regul. Toxicol. Pharmacol. 55 (2009) 291-299
-
(2009)
Regul. Toxicol. Pharmacol.
, vol.55
, pp. 291-299
-
-
Creton, S.1
Billington, R.2
Davies, W.3
Dent, M.4
Hawksworth, G.5
Parry, S.6
Travis, K.7
-
8
-
-
73649130953
-
Acute toxicity testing of chemicals-opportunities to avoid redundant testing and use alternative approaches
-
in press
-
Creton, S., Dewhurst, I.C., Earl, L.K., Gehen, S.C., Guest, R., Hotchkiss, J.A., Indans, I., Woolhiser, M.R., Billington, R., 2009b. Acute toxicity testing of chemicals-opportunities to avoid redundant testing and use alternative approaches. Crit. Rev. Toxicol., in press.
-
(2009)
Crit. Rev. Toxicol
-
-
Creton, S.1
Dewhurst, I.C.2
Earl, L.K.3
Gehen, S.C.4
Guest, R.5
Hotchkiss, J.A.6
Indans, I.7
Woolhiser, M.R.8
Billington, R.9
-
9
-
-
0142177156
-
Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products'. European Commission
-
EC. Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products'. European Commission. Off. J. Eur. Union L66 (2003) 26-35
-
(2003)
Off. J. Eur. Union
, vol.L66
, pp. 26-35
-
-
EC1
-
10
-
-
51849127476
-
Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restrictions of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives
-
EC. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restrictions of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Off. J. Eur. Union L396 (2006) 1-849
-
(2006)
Off. J. Eur. Union
, vol.L396
, pp. 1-849
-
-
EC1
-
13
-
-
0036972762
-
ECVAM's activities in validating alternative tests for skin corrosion and irritation
-
Fentem J.H., and Botham P.A. ECVAM's activities in validating alternative tests for skin corrosion and irritation. Altern. Lab Anim. 30 Suppl 2 (2002) 61-67
-
(2002)
Altern. Lab Anim.
, vol.30
, Issue.SUPPL. 2
, pp. 61-67
-
-
Fentem, J.H.1
Botham, P.A.2
-
14
-
-
69349104947
-
Chemical regulators have overreached
-
Hartung T., and Rovida C. Chemical regulators have overreached. Nature 460 (2009) 1080-1081
-
(2009)
Nature
, vol.460
, pp. 1080-1081
-
-
Hartung, T.1
Rovida, C.2
-
15
-
-
70349764058
-
Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing
-
Holmes A.M., Brown R., and Shakesheff K. Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing. Regen. Med. 4 (2009) 579-592
-
(2009)
Regen. Med.
, vol.4
, pp. 579-592
-
-
Holmes, A.M.1
Brown, R.2
Shakesheff, K.3
-
19
-
-
58149107977
-
Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay
-
Jagger C., Tate M., Cahill P.A., Hughes C., Knight A.W., Billinton N., and Walmsley R.M. Assessment of the genotoxicity of S9-generated metabolites using the GreenScreen HC GADD45a-GFP assay. Mutagenesis 24 (2009) 35-50
-
(2009)
Mutagenesis
, vol.24
, pp. 35-50
-
-
Jagger, C.1
Tate, M.2
Cahill, P.A.3
Hughes, C.4
Knight, A.W.5
Billinton, N.6
Walmsley, R.M.7
-
21
-
-
57349116822
-
Application of a systems biology approach for skin allergy risk assessment
-
Maxwell G., and Mackay C. Application of a systems biology approach for skin allergy risk assessment. AATEX 14 (2008) 381-388
-
(2008)
AATEX
, vol.14
, pp. 381-388
-
-
Maxwell, G.1
Mackay, C.2
-
22
-
-
85054111147
-
-
NC3Rs, 2007. Challenging the regulatory requirement for acute toxicity studies in the development of new medicines: a workshop report
-
NC3Rs, 2007. Challenging the regulatory requirement for acute toxicity studies in the development of new medicines: a workshop report. http://www.nc3rs.org.uk/downloaddoc.asp?id=559&page=22&skin=0.
-
-
-
-
23
-
-
85054107539
-
-
NC3Rs, 2009a. Animals in the chemical industry
-
NC3Rs, 2009a. Animals in the chemical industry. www.nc3rs.org.uk/chemicals.
-
-
-
-
24
-
-
85054115847
-
-
NC3Rs, 2009b. Encouraging commercialisation of tissue engineering-a speed-networking event
-
NC3Rs, 2009b. Encouraging commercialisation of tissue engineering-a speed-networking event. www.nc3rs.org.uk/speednetworking.
-
-
-
-
25
-
-
85054115299
-
-
NC3Rs, 2009c. Funded small awards
-
NC3Rs, 2009c. Funded small awards. www.nc3rs.org.uk/page.asp?id=290.
-
-
-
-
27
-
-
0036226331
-
Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products
-
Robinson M.K., Cohen C., De Fraissinette Ade B., Ponec M., Whittle E., and Fentem J.H. Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products. Food Chem. Toxicol. 40 (2002) 573-592
-
(2002)
Food Chem. Toxicol.
, vol.40
, pp. 573-592
-
-
Robinson, M.K.1
Cohen, C.2
De Fraissinette Ade, B.3
Ponec, M.4
Whittle, E.5
Fentem, J.H.6
-
28
-
-
69249231966
-
Are acute toxicity studies required to support overdose for new medicines?
-
Robinson S., and Chapman K. Are acute toxicity studies required to support overdose for new medicines?. Regul. Toxicol. Pharmacol. 55 (2009) 110
-
(2009)
Regul. Toxicol. Pharmacol.
, vol.55
, pp. 110
-
-
Robinson, S.1
Chapman, K.2
-
29
-
-
41949094635
-
A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development
-
Robinson S., Delongeas J.L., Donald E., Dreher D., Festag M., Kervyn S., Lampo A., Nahas K., Nogues V., Ockert D., Quinn K., Old S., Pickersgill N., Somers K., Stark C., Stei P., Waterson L., and Chapman K. A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development. Regul. Toxicol. Pharmacol. 50 (2008) 345-352
-
(2008)
Regul. Toxicol. Pharmacol.
, vol.50
, pp. 345-352
-
-
Robinson, S.1
Delongeas, J.L.2
Donald, E.3
Dreher, D.4
Festag, M.5
Kervyn, S.6
Lampo, A.7
Nahas, K.8
Nogues, V.9
Ockert, D.10
Quinn, K.11
Old, S.12
Pickersgill, N.13
Somers, K.14
Stark, C.15
Stei, P.16
Waterson, L.17
Chapman, K.18
-
30
-
-
33644980134
-
Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies
-
Saghir S.A., Mendrala A.L., Bartels M.J., Day S.J., Hansen S.C., Sushynski J.M., and Bus J.S. Strategies to assess systemic exposure of chemicals in subchronic/chronic diet and drinking water studies. Toxicol. Appl. Pharmacol. 211 (2006) 245-260
-
(2006)
Toxicol. Appl. Pharmacol.
, vol.211
, pp. 245-260
-
-
Saghir, S.A.1
Mendrala, A.L.2
Bartels, M.J.3
Day, S.J.4
Hansen, S.C.5
Sushynski, J.M.6
Bus, J.S.7
-
31
-
-
67649400889
-
Assuring consumer safety without animals: applications for tissue engineering
-
Westmoreland C., and Holmes A.M. Assuring consumer safety without animals: applications for tissue engineering. Organogenesis 5 (2009) 67-72
-
(2009)
Organogenesis
, vol.5
, pp. 67-72
-
-
Westmoreland, C.1
Holmes, A.M.2
-
32
-
-
67650624126
-
An investigation into corneal alkali burns using an organ culture model
-
Zhao B., Ma A., Martin F.L., and Fullwood N.J. An investigation into corneal alkali burns using an organ culture model. Cornea 28 (2009) 541-546
-
(2009)
Cornea
, vol.28
, pp. 541-546
-
-
Zhao, B.1
Ma, A.2
Martin, F.L.3
Fullwood, N.J.4
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