A listeria monocytogenes strain is still virulent despite nonfunctional major virulence genes

Journal of Infectious Diseases

Volumn 200, Issue 12, 2009, Pages 1944-1948

  Roche, S M ^a   Grepinet O ^a   Corde, Y ^a   Teixeira, A P ^a   Kerouanton, A ^b   Temoin S ^a   Mereghetti, L ^c   Brisabois, A ^b   Velge, P ^a  

^a UR1282   (France)

^b Healthy Pigs Production and Experimentation Section   (France)

^c UNIVERSITÉ DE TOURS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; INTERNALIN A; PHOSPHATIDYLCHOLINE PHOSPHOLIPASE C; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL LYASE; PHOSPHOLIPASE C; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; EVOLUTION; GENE MUTATION; HUMAN; HUMAN CELL; LISTERIA MONOCYTOGENES; MPL GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SEQUENCE ANALYSIS;

ANIMALS; BACTERIAL PROTEINS; CELL LINE; GENE DELETION; HUMANS; LISTERIA MONOCYTOGENES; LISTERIOSIS; MEMBRANE PROTEINS; MICE; PHOSPHOINOSITIDE PHOSPHOLIPASE C; TYPE C PHOSPHOLIPASES; VIRULENCE; VIRULENCE FACTORS;

EID: 71949114566     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/648402     Document Type: Article

References (15)

1. Norrung B, Andersen JK. Variations in virulence between different electrophoretic types of Listeria monocytogenes. Lett Appl Microbiol 2000; 30:228-232
2. Roche SM, Velge P, Bottreau E, Durier C, Marquet-van der Mee N, Pardon P. Assessment of the virulence of Listeria monocytogenes: agreement between a plaque-forming assay with HT-29 cells and infection of immunocompetent mice. Int J Food Microbiol 2001; 68:33-44.
3. Roche SM, Gracieux P, Albert I, et al. Experimental validation of low virulence in field strains of Listeria monocytogenes. Infect Immun 2003; 71:3429-3436
4. 4. Roche SM, Gracieux P, Milohanic E, et al. Investigation of specific substitutions in virulence genes characterizing phenotypic groups of low-virulence field strains of Listeria monocytogenes. Appl Environ Microbiol 2005; 71:6039-6048 (Pubitemid 41456899)
5. Temoin S, Roche SM, Grepinet O, Fardini Y, Velge P. Multiple point mutations in virulence genes explain the low virulence of Listeria monocytogenes field strains. Microbiology 2008; 154:939-948
6. Raffelsbauer D, Bubert A, Engelbrecht F, et al. The gene cluster inlC2DE of Listeria monocytogenes contains additional new internalin genes and is important for virulence in mice. Mol Gen Genet 1998; 260:144-158
7. Yeung PS, Zagorski N, Marquis H. The metalloprotease of Listeria monocytogenes controls cell wall translocation of the broad-range phospholipase C. J Bacteriol 2005; 187:2601-2608
8. Seveau S, Pizarro-Cerda J, Cossart P. Molecular mechanisms exploited by Listeria monocytogenes during host cell invasion. Microbes Infect 2007; 9:1167-1175
9. Lecuit M. Human listeriosis and animal models. Microbes Infect 2007; 9:1216-1225
10. Bierne H, Sabet Q Personnic N, Cossart P. Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes. Microbes Infect 2007; 9:1156-1166
11. Sabet C, Toledo-Arana A, Personnic N, et al. The Listeria monocytogenes virulence factor InlJ is specifically expressed in vivo and behaves as an adhesin. Infect Immun 2008; 76:1368-1378
12. Engelbrecht F, Chun SK, Ochs C, et al. A new prfa-regulated gene of Listeria monocytogenes encoding a small, secreted protein which belongs to the family of internalins. Molecular Microbiology 1996; 21:823-837
13. Kirchner M, Higgins DE. Inhibition of ROCK activity allows InlFmediated invasion and increased virulence of Listeria monocytogenes. Mol Microbiol 2008; 68:749-767
14. Portnoy DA, Chakraborty T, Goebel W, Cossart P. Molecular determinants of Listeria-Monocytogenes pathogenesis. Infect Immun 1992; 60: 1263-1267
15. Vazquez-Boland JA, Kuhn M, Berche P, et al. Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev 2001; 14:584-640.