Characterizing the origin of the arterial spin labelling signal in MRI using a multiecho acquisition approach

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 11, 2009, Pages 1836-1845

  Wells, Jack A ^a,b   Lythgoe, Mark F ^a,b   Choy, Mankin ^a,b   Gadian, David G ^b   Ordidge, Roger J ^a   Thomas, David L ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Arterial spin labelling; Cerebral blood flow; Cerebral perfusion; Extracellular; Intracellular; Transverse relaxtion

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY BLOOD FLOW; ARTICLE; BRAIN BLOOD FLOW; BRAIN SIZE; CONTROLLED STUDY; ECHO PLANAR IMAGING; EXTRACELLULAR SPACE; IMAGE ANALYSIS; INTRACELLULAR SPACE; INTRAVASCULAR SPACE; LABELING INDEX; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PULSE WAVE; RAT; SPIN LABELING;

ANIMALS; BODY WATER; BRAIN; CEREBROVASCULAR CIRCULATION; ECHO-PLANAR IMAGING; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SPIN LABELS;

EID: 71949101209     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2009.99     Document Type: Article

References (45)

1. Alsop DC, Detre JA (1996) Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 16:1236-1249 (Pubitemid 26365376)
2. Bakay L (1970) The extracellular space in brain tumours. I. Morphological considerations. Brain 93:693-698
3. Belton PS, Jackson RR, Packer J (1972) Transverse nuclear relaxation and spin effects. Biochim Biophys ACTA 286:16-25
4. Buxton RB, Frank LR, Wong EC, Siewert B, Warach S, Edelman RR (1998) A general kinetic model for quantitative perfusion imaging with arterial spin labelling. Magn Reson Med 40:383-396 (Pubitemid 28391899)
5. Detre JA, Leigh JS, Williams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23:37-45
6. Duong TG, Sehy JV, Yablonskiy DA, Snider BJ, Ackerman JJH, Neil JJ (2001) Extracellular apparent diffusion in rat brain. Magn Reson Med 45:801-810
7. Eichling J, Raichle M, Grubb R, Ter-Pogossian M (1974) Evidence of the limitations of water asa freely diffusible tracer. Circ Res 35:358-364
8. Francis ST, Bowtell R, Gowland PA (2008) Modeling and optimization of Look-Locker spin labeling for measuring perfusion and transit time changes in activation studies taking into account arterial blood volume. Magn Reson Med 59:316-325 (Pubitemid 351220095)
9. Gambarota G, Cairns BE, Berde CB, Mulkern RV (2001) Osmotic effects on the T2 relaxation decay of in vivo muscle. Magn Reson Med 26:592-599 (Pubitemid 32831336)
10. Golay X, Silvennoinen MJ, Zhou J, Clingman CS, Kauppinen RA, Pekar JJ, van Zij PC (2001) Measurement of tissue oxygen extraction ratios from venous blood T(2): increased precision and validation of principle. Magn Reson Med 46:282-291 (Pubitemid 32703273)
11. Gudbjartsson H, Patz P (1994) The rician distribution of noisy MRI data. Magn Reson Med 34:910-914
12. Haida M, Yamamoto M, Matsumura H, Shinohara Y, Fukuzaki M (1987) Intracellular and extracellular spaces of normaladult rat brain determined from the proton nuclear magnetic resonance relaxation times. J Cereb Blood Flow Metab 7:552-556
13. Hazlewood CF, Chang DC, Nichols BL, Woessner DE (1974) Nuclear magnetic resonance relaxation times of water protons in skeletal muscle. Biophys J 14:583-606
14. He, Yablonskiy (2007) Transverse relaxation of the perfusion MRI signal. ISMRM workshop on cerebral perfusion and brain junction. Salvador da Bahia, Brazil
15. Henkelman RM, Neil JJ, Xiang QS (1994) A quantitative interpretation of IVIM measurements of vascular perfusion in the rat brain. Magn Reson Med 32:464-469
16. Kim T, Kim SG (2006) Quantification of cerebral arterial blood volume using arterial spin labeling with intravoxel incoherent motion-sensitive gradients. Magn Reson Med 55:1047-1057
17. King MD, van Bruggen N, Busza AL, Houseman J, Williams SR, Gadian DG (1992) Perfusion and diffusion MR imaging. Magn Reson Med 24:288-301
18. Kober F, Duhamel G, Cozzone PJ (2008) Experimental comparison of four FAIR arterial spin labelling techniques for quantification of mouse cerebral blood flow at 4.7T. NMR Biomed 21:781-792
19. Lascialfari A, Zucca I, Asdente M, Cimino M, Guerrini U, Paoletti R, Tremoli E, Lorusso V, Sironi L (2005) Multiexponential T2-relaxation analysis in cerebrally damaged rats in the absence and presence of a gadolinium contrast agent. Magn Reson Med 53:1326-1332 (Pubitemid 40734652)
20. Liang Z-P, Boada FE, Constable RT, Haacke EM, Lauterbur PC, Smith MR (1992) Constrained reconstruction methods in MR imaging. Rev Magn Reson 4:67-185
21. Liang Z, Lauterbur PC (2000) Principles of magnetic resonance imaging. A signal processing perspective. Wiley-IEEE Press
22. 2* of brain parenchyma accurately reflect the combined effects of changes in arterial and cerebral venous oxygen saturation. Magn Reson Med 39:374-481
23. Matsumae M, Oli S, Watanabe H, Okamoto K, Suzuji Y, Sato K, Atsumi H, Goto T, Tsugane R (2003) Distribution of intracellular and extracellular water molecules in developing rat's midbrain: comparison with fraction of multicomponent T2 relaxation time and morphological findings from electron microscopic imaging. Childs Nerv Syst 19:91-95 (Pubitemid 36798760)
24. Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR (1990) Early detection of regional cerebral ischemia in cats: comparison of diffusion and T2-weighted MRI and spectroscopy. Magn Reson Med 14:330-346 (Pubitemid 20248617)
25. Neil JJ, Scherrer LA, Ackerman JJH (1991) An approach to solving the dynamic range problem in measurement of the pseudodiffusion coefficient in Vivo with spin echoes. J Magn Reson 95:607-614
26. Parkes LM, Tofts PS (2002) Improved accuracy of human cerebral blood perfusion measurements using arterial spin labelling: accounting for capillary water. Magn Reson Med 48:27-41
27. Petersen ET, Lim T, Golay X (2006) Model-free arterial spin labelling quantification approach for perfusion MRI. Magn Reson Med 55:219-232 (Pubitemid 43238088)
28. Petersen ET, Golay X (2008) Is arterial spin labelling ready for the prime time? Preliminary results from the QUASAR reproducibility study. Proc Int Soc Magn Reson Med ;191
29. Poon CS, Henkelman RM (1992) Practical T2 quantification for clinical applications. J Magn Reson 2:541-553
30. Quirk JD, Bretthorst GL, Duong TQ, Snyder AZ, Springer CS, Jr, Ackerman JH, Neil JJ (2003) Equilibrium water exchange between the intra- and extracellular spaces of mammalian brain. Magn Reson Med 50:493-499
31. Silva AC, Williams DS, Koretsky AP (1997a) Evidence for the exchange of arterial spin labeled water with tissue water in rat brain from diffusion-sensitized measurements of perfusion. Magn Reson Med 38:232-237
32. Silva AC, Zhang WG, Williams DS, Koretsky AP (1997b) Estimation of water extraction fractions in rat brain using magnetic resonance measurement of perfusion with arterial spin labeling. Magn Reson Med 37:58-68
33. Stanitz GJ, Odrobina EE, Pun J, Escaravage M, Graham SJ, Bronskill MJ, Henkelman RM (2005) T1, T2 relaxation and magnetization transfer in tissue at 3T. Magn Reson Med 54:507-512
34. St Lawrence KS, Wang J (2005) Effects of the apparent transverse relaxation time on cerebral blood flow measurements obtained by arterial spin labeling. Magn Reson Med 53:425-433
35. Thomas DL, Lythgoe MF, Pell GS, Calamante F, Ordidge RJ (2000) The measurement of diffusion and perfusion in biological systems using magnetic resonance imaging. Phys Med Biol 45:97-138 (Pubitemid 30622538)
36. Thomas DL, Lythgoe MF, Calamante F, Gadian DG, Ordidge RJ (2001) Simultaneous non-invasive measurement of CBF and CBV using double-echo FAIR (DEFAIR). Magn Reson Med 45:853-863 (Pubitemid 32402028)
37. Thomas DL, Lythgoe MF, van de Weerd L, Ordidge RJ, Gadian DG (2006) Regional variation of cerebral blood flow and arterial transit time in normaland hyperfused rat brain measured using continuous arterial spin labelling MRI. J Cereb Blood Flow Metab 26:274-282
38. Turner R, Howseman A, Rees GE, Josephs O, Friston K (1998) Functional magnetic resonance imaging of the human brain: data acquisition and analysis. Exp Brain Res 123:5-12 (Pubitemid 28495290)
39. Villringer A, Them A, Lindauer U, Einhaaupl K, Dirangl U (1994) Capillary perfusion of the rat brain cortex: an in vitro confocal microscopy study. Circ Res 75:55-62 (Pubitemid 24187735)
40. Wang J, Alsop DC, Song HK, Maldjian JA, Tang K, Salvucci AE, Detre JA (2003) Arterial transit time imaging with flow encoding arterial spin tagging (FEAST). Magn Reson Med 50:599-607 (Pubitemid 37082085)
41. Wang J, Fernández-Seara MA, Wang S, St Lawrence KS (2007) When perfusion meets diffusion; in vivo measurement of water permeability in human brain. J Cereb Blood Flow Metab 27:839-849 (Pubitemid 46474624)
42. Wells JA, Thomas DL, King MD, Connelly A, Lythgoe MF, Calamante F (2007) Reduction of random errors in ASL cerebral perfusion and arterial transit time maps using image de-noising. Proc Br Soc Magn Reson Med 13:44
43. Zaharchuk G, Bogdanov AA, Jr, Marota JJA, Shimizu- Sasamata M, Weisskoff RM, Kwong KK, Jenkins BG, Weissleder R, Rosen BR (1998) Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction and the water extraction fraction. Magn Reson Med 40:666-678 (Pubitemid 28493642)
44. Zhou JY, Wilson DA, Ulatowski JA, Trajstman RJ, van Zijl PCM (2001) Two-compartment exchange model for perfusion quantification using arterial spin tagging. J Cereb Blood Flow Metab 21:440-455
45. Zhao JM, Clingman CS, Narvainen MJ, Kauppinen RA, van Zijl PCM (2007) Oxygenation and hematocrit dependence of transverse relaxation rates of blood at 3T. Magn Reson Med 58:592-596