Transplanted olfactory mucosal cells restore paw reaching function without regeneration of severed corticospinal tract fibres across the lesion

Brain Research

Volumn 1303, Issue , 2009, Pages 26-31

  Yamamoto, Mie ^a,b   Raisman, Geoffrey ^a   Li, Daqing ^a   Li, Ying ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Adult; Repair; Spinal Cord; Sprouting

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN FUNCTION; CELL CULTURE; CELL STRUCTURE; CELL TRANSPLANTATION; CONTROLLED STUDY; FEMALE; FIBROBLAST; HISTOPATHOLOGY; MUCOSA CELL; NERVE FIBER; NONHUMAN; OLFACTORY BULB; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PYRAMIDAL TRACT; RAT;

ANIMALS; BIOTIN; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; DEXTRANS; FEMALE; FIBROBLASTS; FORELIMB; GRAFT SURVIVAL; GREEN FLUORESCENT PROTEINS; GROWTH CONES; MOVEMENT; NERVE REGENERATION; OLFACTORY MUCOSA; PARALYSIS; PYRAMIDAL TRACTS; RATS; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; STAINING AND LABELING; STEM CELLS; TISSUE TRANSPLANTATION; TREATMENT OUTCOME;

RATTUS;

EID: 71849092985     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.09.073     Document Type: Article

References (33)

1. Anderson K.D., Gunawan A., and Steward O. Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract. Exp. Neurol. 194 (2005) 161-174
2. Anderson K.D., Gunawan A., and Steward O. Spinal pathways involved in the control of forelimb motor function in rats. Exp. Neurol. 206 (2007) 318-331
3. Bareyre F.M., Kerschensteiner M., Raineteau O., Mettenleiter T.C., Weinmann O., and Schwab M.E. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat. Neurosci. 7 (2004) 269-277
4. Barnett S.C., Hutchins A.-M., and Noble M. Purification of olfactory nerve ensheathing cells from the olfactory bulb. Dev. Biol. 155 (1993) 337-350
5. Brus-Ramer M., Carmel J.B., Chakrabarty S., and Martin J.H. Electrical stimulation of spared corticospinal axons augments connections with ipsilateral spinal motor circuits after injury. J. Neurosci. 27 (2007) 13793-13801
6. Cavalieri S., Cazzaniga S., Geuna M., Magnani Z., Bordignon C., Naldini L., and Bonini C. Human T lymphocytes transduced by lentiviral vectors in the absence of TCR activation maintain an intact immune competence. Blood 102 (2003) 497-505
7. Choi D., Law S., Raisman G., and Li D. Olfactory ensheathing cells in the nasal mucosa of the rat and human. Br. J. Neurosurg. 22 (2008) 301-302
8. Deumens R., Koopmans G.C., Honig W.M., Hamers F.P., Maquet V., Jerome R., Steinbusch H.W., and Joosten E.A. Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord. Exp. Neurol. 200 (2006) 89-103
9. Féron F., Perry C., Cochrane J., Licina P., Nowitzke A., Urquhart S., Geraghty T., and Mackay-Sim A. Autologous olfactory ensheathing cell transplantation in human spinal cord injury. Brain 128 (2005) 2951-2960
10. Girgis J., Merrett D., Kirkland S., Metz G.A., Verge V., and Fouad K. Reaching training in rats with spinal cord injury promotes plasticity and task specific recovery. Brain 130 (2007) 2993-3003
11. Ibrahim A.G., Kirkwood P.A., Raisman G., and Li Y. Restoration of hand function in a rat model of repair of brachial plexus injury. Brain 132 (2009) 1268-1276
12. Imaizumi T., Langford K.L., Waxman S.G., Greer C.A., and Kocsis J.D. Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord. J. Neurosci. 18 (1998) 6176-6185
13. Jeffery N.D., Lakatos A., and Franklin R.J.M. Autologous olfactory glial cell transplantation is reliable and safe in naturally-occurring canine spinal cord injury. J. Neurotrauma 22 (2005) 1282-1293
14. Kanagal S.G., and Muir G.D. Task-dependent compensation after pyramidal tract and dorsolateral spinal lesions in rats. Exp. Neurol. 216 (2009) 193-206
15. Keyvan-Fouladi N., Raisman G., and Li Y. Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheathing cells in adult rats. J. Neurosci. 23 (2003) 9428-9434
16. Lakatos A., Smith P.M., Barnett S.C., and Franklin R.J. Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells. Brain 126 (2003) 598-609
17. Li Y., Field P.M., and Raisman G. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 277 (1997) 2000-2002
18. Li Y., Field P.M., and Raisman G. Regeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells. J. Neurosci. 18 (1998) 10514-10524
19. Li Y., Li D., Khaw P.T., and Raisman G. Transplanted olfactory ensheathing cells incorporated into the optic nerve head ensheathe retinal ganglion cell axons: possible relevance to glaucoma. Neurosci. Lett. 440 (2008) 251-254
20. Lu J., Féron F., Mackay-Sim A., and Waite P.M.E. Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 125 (2002) 14-21
21. Maier I.C., Baumann K., Thallmair M., Weinmann O., Scholl J., and Schwab M.E. Constraint-induced movement therapy in the adult rat after unilateral corticospinal tract injury. J. Neurosci. 28 (2008) 9386-9403
22. Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., and Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272 (1996) 263-267
23. Ramer L.M., Au E., Richter M.W., Liu J., Tetzlaff W., and Roskams A.J. Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injury. J. Comp. Neurol. 473 (2004) 1-15
24. Ramón-Cueto A., and Valverde F. Olfactory bulb ensheathing glia: A unique cell type with axonal growth-promoting properties. Glia 14 (1995) 163-173
25. Ramón-Cueto A., Plant G.W., Avila J., and Bunge M.B. Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants. J. Neurosci. 18 (1998) 3803-3815
26. Ramón-Cueto A., Cordero M.I., Santos-Benito F.F., and Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 25 (2000) 425-435
27. Richter M.W., Fletcher P.A., Liu J., Tetzlaff W., and Roskams A.J. Lamina propria and olfactory bulb ensheathing cells exhibit differential integration and migration and promote differential axon sprouting in the lesioned spinal cord. J. Neurosci. 25 (2005) 10700-10711
28. Ruitenberg M.J., Plant G.W., Christensen C.L., Blits B., Niclou S.P., Harvey A.R., Boer G.J., and Verhaagen J. Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord. Gene Ther. 9 (2002) 135-146
29. Steward O., Sharp K., Selvan G., Hadden A., Hofstadter M., Au E., and Roskams J. A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats. Exp. Neurol. 198 (2006) 483-499
30. Toft A., Scott D.T., Barnett S.C., and Riddell J.S. Electrophysiological evidence that olfactory cell transplants improve function after spinal cord injury. Brain 130 (2007) 970-984
31. Vavrek R., Girgis J., Tetzlaff W., Hiebert G.W., and Fouad K. BDNF promotes connections of corticospinal neurons onto spared descending interneurons in spinal cord injured rats. Brain 129 (2006) 1534-1545
32. Weidner N., Ner A., Salimi N., and Tuszynski M.H. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 3513-3518
33. Yamamoto M., Raisman G., and Li Y. Loss of directed fore-limb reaching after destruction of spinal grey matter. Brain Res. 1265 (2009) 47-52