Efficient production of gossypol from hairy root cultures of cotton (Gossypium hirsutum L.)

Current Pharmaceutical Biotechnology

Volumn 10, Issue 7, 2009, Pages 691-700

  Verma, Praveen C ^a   Trivedi, Ila ^a   Singh, Harpal ^a   Shukla, Anoop K ^a   Kumar, Manoj ^a   Upadhyay, Santosh K ^a   Pandey, Paras ^a   Hans, Aradhana L ^a   Singh, Pradhyumna K ^a  

^a CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

Agrobacterium rhizogenes; Cotton; Gossypium hirsutum; Gossypol; Hairy roots

Indexed keywords

GOSSYPOL; PANTOTHENIC ACID; PROTEIN ROL B; PROTEIN ROL C; UNCLASSIFIED DRUG; VEGETABLE PROTEIN;

ARTICLE; BACTERIAL STRAIN; BIOTECHNOLOGICAL PRODUCTION; CONTROLLED STUDY; COTTON; ENZYME SYNTHESIS; GENE AMPLIFICATION; GENE EXPRESSION; GOSSYPIUM HIRSUTUM; HAIRY ROOT CULTURE; KINETICS; MURASHIGE AND SKOOG MEDIUM; NONHUMAN; PLANT GROWTH; PLANT LEAF; POLYMERASE CHAIN REACTION; PROTEIN ANALYSIS; RHIZOBIUM RHIZOGENES;

CELL LINE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE EXPRESSION REGULATION, PLANT; GENES, PLANT; GOSSYPIUM; GOSSYPOL; PLANT LEAVES; PLANT ROOTS; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

AGROBACTERIUM RHIZOGENES; GOSSYPIUM HIRSUTUM;

EID: 71849091560     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109789542048     Document Type: Article

References (74)

1. Bell, A.A.; Stipanovic, R.D.; Howell, C.R. and Fryxell, P.A. (1975) Antimicrobial terpenoids of Gossypium: Hemigossypol, 6-methoxyhemigossypol and 6-deoxyhemigossypol. Phytochemistry, 14(1), 225-231.
2. Dowd, M.K. and Pelitire, S.M. (2006) Isolation of 6-methoxy gossypol and 6, 6-dimethoxy gossypol from Gossypium barbadense sea island. J. Agric. Food Chem., 54(9), 3265-3270.
3. McClure, M. A. (1971) Gas-liquid chromatography of gossypol. J. Chromatogr., 54(1), 25-31.
4. Smith, F. H. (1961) Biosynthesis of gossypol by excised cotton roots. Nature, 192(4805), 888-889.
5. Mace, M.E.; Bell, A.A. and Stipanovic, R.D. (1974) Histochemistry and isolation of gossypol and related terpenoids in roots of cotton seedlings. Phytopathology, 64, 1297-1302.
6. Hunter, R.E.; Halloin, J. M.; Veech, J.A. and Carter, W.W. (1978) Exudation of terpenoids by cotton roots. Plant Soil, 50(1-3), 237-240.
7. Stipanovic, R.D.; Altman, D.W.; Begin, D. L.; Greenblatt, G.A. and Benedict, J.H. (1988) Terpenoid aldehydes in upland cottons: analysis by aniline and HPLC methods. J. Agric. Food Chem., 36(3), 509-515.
8. Abraham, K.J.; Pierce, M.L. and Essenberg, M. (1999) The phytoalexins desoxyhemigossypol and hemigossypol are elicited by Xanthomonas in Gossypium cotyledons. Phytochemistry, 52(5), 829-836.
9. Liu, J.; Benedict, C.R.; Stipanovic, R.D. and Bell, A.A. (1999) Purification and characterization of S-adenosyl-L-methionine: desoxyhemigossypol-6-O-methyltransferase from cotton plants. Plant Physiol., 121(3), 1017-1024.
10. Puckhaber, L.S.; Dowd, M.K.; Stipanovic, R.D. and Howell, C.R. (2002) Toxicity of (+) and (-)-Gossypol to the Plant Pathogen, Rhizoctonia solani. J. Agric. Food Chem., 50(24), 7017-7021. (Pubitemid 35332777)
11. Yildirim-Aksoy, M.; Lim, C.; Dowd, M.; Wan, P.J.; Klesius, P.H. and Shoemaker, C. J. (2004) In vitro inhibitory effect of gossypol from gossypol-acetic acid, and (+)-and (-)-isomers of gossypol on the growth of Edwardsiella ictaluri. J. Appl. Microbiol., 97(1), 87-92. (Pubitemid 38869885)
12. Lee, K.J. and Dabrowski, K. (2002) Gossypol and gossypolone enantiomers in tissues of rainbow trout fed low and high levels of dietary cottonseed meal. J. Agric. Food Chem., 50(10), 3056-3061.
13. Lindberg, C.; Naqvi, R.H.; Matlin, S.A.; Zhou, R.H.; Bailey, G. and Blye, R.P. (1987) Comparative anti-fertility effects of gossypol enantiomers in male hamsters. Int. J. Androl., 10(4), 619-623.
14. Band, V.; Hoffer A.P.; Band, H.; Rhinehardt, A.E.; Knapp, R.C.; Malin, S.A. and Anderson, D.J. (1989) Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell lines. Gynecol. Oncol., 32(3), 273-277.
15. Cui, G.H.; Xu, Z.L.; Yang, Z.J.; Xu, Y.Y. and Xue, S.P. (2004) A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis expression of its related genes in rats. Contraception, 70(4), 335-342.
16. Le blanc, M.L.; Russo, J.; Kudelka, A.P. and Smith, J.A. (2002) An in-vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines. Pharmacol. Res., 46(6), 551-555.
17. Liu, S.; Kulp, S.K.; Sugimoto, Y.; Jiang, J.; Chang, H.L.; Dowd, M.K.; Wan, P. and Lin, Y.C. (2002) The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. Anticancer Res., 22(1), 33-38. (Pubitemid 34475272)
18. Xu, L.; Yang, D.; Wang, S.; Tang, W.; Liu, M.; Davis, M.; Chen, J.; Rae, J. M.; Lawrence, T. and Lippman, M.E. (2005) (-)- Gossypol enhances responses to radiation therapy and results in tumor regression of human prostate cancer. Mol. Cancer Ther., 4(2), 197-205. (Pubitemid 40340199)
19. Lin, T.S.; Schanazi, R. F.; Zhu, J.; Birks, E.; Carbone, R.; Si, Y.; Wu, K.; Huang, L. and Prusoff, W.H. (1993) Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. Biochem. Pharmacol., 46(2), 251-255. (Pubitemid 23218609)
20. Vander Jagt, D.L.; Deck, L. M. and Royer, R.E. (2000) Gossypol: prototype of inhibitors targeted to antiviral activity against enveloped viruses including HIV. Curr. Med. Chem., 7(4), 479-498.
21. Pons, W.A.Jr.; Pominsky, J.; King, W.H.; harris, J.A. and Hopper, T.H. (1959) Recovery of gossypol from cottonseed gums. J. Am. Oil Chem. Soc., 36(8), 328-332.
22. Dowd, M.K. and Pelitire, S. M. (2001) Recovery of gossypol acetic acid from cottonseed soapstock. Ind. Crops Prod., 14(2), 113-123.
23. Royce, H. D.; Hahn, J.R. and Hahn, E.R. (1941) Cotton-root barks as a source of gossypol. Oil Soap, 18(2), 27-29.
24. Bensaddek, L.; Villarreal, M. L. and Fliniaux, M.A. (2008) Induction and growth of hairy roots for the production of medicinal compounds. Electron. J. Integr. Biosci., 3(1), 2-9.
25. Guillon, S.; Tremouillaux-Guiller, J.; Pati, P.K.; Rideau, M. and Gantet, P. (2006) Harnessing the potential of hairy roots: dawn of a new era. Trends Biotechnol., 24(9), 403-409. (Pubitemid 44226496)
26. Hu, Z-B. and Du, M. (2006) Hairy roots and its application in plant genetic engineering. J. Integr. Plant Biol., 48(2), 121-127.
27. Milen, G.; Atanas, P. and Thomas, B. (2007) Hairy root type plant in vitro systems as sources of bioactive substances. Appl. Microbiol. Biotechnol., 74(6), 1175-1185.
28. Srivastava, S. and Srivastava, A. K. (2007) Hairy root culture for mass-production of high-value secondary metabolites. Crit. Rev. Biotechnol., 27(1), 29-43. (Pubitemid 46425933)
29. Kumar, M.; Shukla, A. K.; Singh, R.; Singh, A. and Tuli, R. (2008) Somtic embryogenesis in an agronomically elite cotton cultivar Khandwa-2 (Gossypium hirsutum L.) In Vitro Cell Devel. Biol.- Plant (In Press)
30. Verma, P.C.; Singh, D.; Rahman, L.U.; Gupta, M.M. and Banerjee, S. (2002) In vitro studies in Plumbago zeylanica: rapid micropropagation and establishment of higher plumbagin yielding hairy root cultures. J. Plant Physiol., 159(5), 547-552.
31. Zhou, X.; Wu, Y.; Wang, X.; Liu, B. and Xu, H. (2007) Salidroside production by hairy roots of Rhodiola sachalinensis obtained after transformation with Agrobacterium rhizogens. Biol. Pharm. Bull., 30(3), 439-442.
32. Alpizar, E.; Dechamp, E.; Lapeyre-Montes, F.; Guilhaumon, C.; Bertrand, B.; Jourdan, C.; Lashermes, P. and Etienne, H. (2008) Agrobacterium rhizogenes-transformed roots of coffee (Coffea arabica): Conditions for long-term proliferation, and morphological and molecular characterization. Ann. Bot., 101(7), 929-940.
33. Kim, J.S.; Lee, S.Y. and Park, S.U. (2008) Resveratrol production in hairy root culture of peanut, Arachis hypogaea L. transformed with different Agrobacterium rhizogenes strains. Afr. J. Biotechnol., 7(20), 3788-3790.
34. Giri, A. and Narasu, M.L. (2000) Transgenic hairy roots: recent trends and application. Biotechnol. Adv., 18(1), 1-22. (Pubitemid 30300754)
35. Nguyen, C.; Bourgaud, F.; Forlot, P. and Guckert, A. (1992) Establishment of hairy root cultures of Psoralea species. Plant Cell Report, 11(8), 424-427.
36. Ryder, M.H.; Tate, M.E. and Kerr, A. (1985) Virulence properties of strains of Agrobacterium on the apical and basal surfaces of carrot root discs. Plant Physiol., 77(1), 215-221.
37. Triplett, B.A.; Moss, S.C.; Bland, J.M. and Dowd, M.K. (2008) Induction of hairy root cultures from Gossypium barbadense to produce gossypol related compounds. In Vitro Cell Dev. Biol.- Plant, 44(6), 508-517.
38. Fu, C.X.; Zhao, D.X.; Xue, X.F.; Jin, Z.P. and Ma, F.S. (2005) Transformation of Saussurea involucrata by Agrobacterium rhizogenes. Hairy root induction and syringin production. Process Biochem., 40(12), 3789-3794.
39. Karthikeyan, A.; Parvathy, S.P.S. and Bhakyaraj, R. (2007) Hairy root induction from hypocotyls segments of groundnut (Arachis hypogea L.). Afr. J. Biotechnol., 6 (15), 1817-1820.
40. Verma, P.C.; Rahman L.U.; Negi, A.S.; Jain, D.C.; Khanuja, S.P.S. and Banerjee, S. (2007) Agrobacterium rhizogenes-mediated transformation of Picrorhiza kurroa Royle ex Benth: establishment and selection of superior hairy root clone. Plant Biotechnol. Report, 1, 169-174.
41. Dhakulkar, S.; Ganapathi, T.R.; Bhargava, S. and Bapat,V.A. (2005) Induction of hairy roots in Gmelina arborea Roxb. and production of verbascoside in hairy roots. Plant Sci., 169(5), 812-818. (Pubitemid 41225292)
42. Bercetche, J.; Chriqui, D.; Adam, S. and David, C. (1987) Morphogenetic and cellular reorientations induced by Agrobacterium rhizogenes (strains 1855, 2659 and 8196) on carrot, pea and tobacco. Plant Sci., 52(3), 195-210.
43. Owens, L.D. and Cress, D.E. (1985) Genotype variability of soybean response to Agrobacterium strains harbouring the Ti or Ri plasmids. Plant Physiol., 77(1), 87-94.
44. Gaudin, V.; Vrain, T. and Jouanin, L. (1994) Bacterial genes modifying hormonal balances in plants. Plant Physiol. Biochem., 32(11), 11-29.
45. Tao, J. and Li, L. (2005) Genetic transformation of Torenia fournieri L. mediated by Agrobacterium rhizogenes. South Afr. J. Botany, 72, 211-216.
46. David, C.; Chilton, M.D. and Tempe, J. (1984) Conservation of TDNA in plants regenerated from hairy root cultures. Biotechnol., 2, 73-76.
47. Sevon, N.; Hiltunen, R. and Oksman-Caldentey, K.M. (1998) Somaclonal variation in transformed roots and protoplast derived hairy root lines of Hyoscyamus muticus. Planta Medica, 64(1), 37-41. (Pubitemid 28059995)
48. Zhao, S.J.; Li, C.Y.; Qian, Y.C.; Luo, X.P.; Zhang, X.; Wang, X.S. and Kang, B.Y. (2004) Induction of hairy roots of Panax ginseng and studies on suitable culture condition of ginseng hairy roots. Sheng. Wu. Gong. Cheng. Xue. Bao., 20(2), 215-220.
49. Li, F.X.; Jin, Z.P.; Zhao, D.X.; Cheng, L.Q.; Fu, C.X. and Ma, F. (2006) Overexpression of the Saussurea medusa chalcone isomerase gene in S. involucrata hairy root cultures enhances their biosynthesis of apigenin. Phytochemistry, 67(6), 553-560.
50. Verma, P.C. (2003) Biotechnological Approaches for In Vitro Production of Picroliv from Agrobacterium rhizogenes Mediated Hairy Root Cultures of Picrorhiza kurroa Royle ex Benth. PhD Thesis, Lucknow University: Lucknow.
51. Pavlov, A.; Georgiev, V. and Ilieva, M. (2005) Betalain biosynthesis by red beet (Beta vulgaris L.) hairy root culture. Process Biochem., 40(5), 1531-1533. (Pubitemid 40240821)
52. Higa, A.; Miyamoto, E.; Rahman, L.U. and Kitamura, Y. (2008) Root tip-dependent, active riboflavin secretion by Hyoscyamus albus hairy roots under iron deficiency. Plant Physiol. Biochem., 46(4), 452-460.
53. Wu, J.Y.; Janet, N.G.; Shi, M. and Wu, S.J. (2007) Enhanced secondary metabolite (tanshinone) production of Salvia miltiorrhiza hairy roots in a novel root-bacteria coculture process. Appl. Microbiol. Biotechnol., 77(3), 543-550. (Pubitemid 350125508)
54. Wysokinska, H. and Chmiel, A. Transformed root cultures for biotechnology. Acta Biotechnol., 17(2), 131-159.
55. Satdive, R. K.; Fulzele, D. P. and Eapen, S. (2007) Enhanced production of azadirachtin by hairy root cultures of Azadirachta indica A. Juss by elicitation and media optimization. J. Biotechnol., 128(2), 281-289.
56. Ludwig-Muller, J.; Georgiev, M. and Bley, T. (2008) Metabolite and hormonal status of hairy root cultures of Devil's claw (Harpagophytum procumbens) in flasks and in a bubble column bioreactor. Process Biochem., 43(1), 15-23. (Pubitemid 350257022)
57. Nabeshima, S.; Mano, Y. and Ohkawa, H. (1986) Production of tropane alkaloids by hairy root cultures of Scopolia japonica. Symbiosis, 2, 11-18.
58. Bourgaud, F.; Gravot, A.; Milesi, S. and Gontier, E. (2001) Production of plant secondary metabolites: a historical perspective. Plant Sci., 161(5), 839-851. (Pubitemid 32995289)
59. Bais, HP.; Vepachedu, R. and Vivanco, J.M. (2003) Root specific elicitation and exudation of fluorescent β-carbolines in transformed root cultures of Oxalis tuberose. Plant Phys. Biochem., 41(4), 345-353. (Pubitemid 36614779)
60. Heinstein, P. and EL-Shagi, H. (1981) Formation of gossypol by Gossypium hirsutum L. cell suspension cultures. J. Nat. Prod., 44(1), 1-6. (Pubitemid 11116187)
61. Trolinder, N.L. and Goodin, J.R. (1988) Somatic embryogenesis in (Gossypium): effect of source of explants and hormone regime. Plant Cell Tissue Organ Cult., 12(1), 31-42.
62. Davidson, G.H. and Hamilton, R.H. (1983) Plant regeneration from callus tissue of Gossypium hirsutum L. Plant Sci. Lett., 32(1-2), 89-93.
63. Baksha, R.; Mavlanov, G.T.; Nasirova, G.B. and Djataev, S.A. (2006) Gossypol accumulation and morphogenesis in Cotton (G.hirsutum L.) callus culture. J. Biol. Sci., 6(6), 1126-1129.
64. Benbouza, H.; Lognay, G.; Palm, R.; Baudoin, J.P. and Mergeai, G. (2002) Development of a visual method to quantify the gossypol content in Cotton seeds. Crop. Sci., 42(6), 1937-1942.
65. Cai,Y.; Zhang, H.; Zeng,Y.; Mo, J.; Bao, J.; Miao, C.; Bai, J.; Yan, F. and Chen, F. (2004) An optimized gossypol high-performance liquid chromatography assay and its application in evaluation of different gland genotypes of cotton. J. Biosci., 29(1), 67-71. (Pubitemid 38419556)
66. Meyer, R.; Vorster, S. and Dubery, I.A. (2004) Identification and quantification of gossypol in cotton by using packed micro-tips columns in combination with HPLC. Anal. Bioanal. Chem., 380(4), 719-724.
67. Sunilkumar, G.; Campbell, L.M.; Puckhaber, L.; Stipanovic, R.D. and Rathore, K.S. (2006) Engineering cottonseed for use in human nutrition by tissue-specific reduction of toxic gossypol. Proc. Natl. Acad. Sci. USA, 103(48), 18054-18059.
68. Murashige, T. and Skoog, F. (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant., 15, 473-497.
69. Gamborg, O.L.; Miller, R.A. and Ojima, K. (1968) Nutrient requirements of suspension cultures of soybean root cells. Exp. Cell Res., 50(1), 151-158.
70. Hooykass, P.J.J.; Klapwijk, P.M.; Nuti, P.M.; Shilperoot, R.A. and Rorsch, A. (1977) Transfer of the Agrobacterium tumefaciens Tiplasmid to a virulent Agrobacteria and Rhizobium explanta. J. General Microbiol., 98, 477-484.
71. Khanna, P. and Staba, J. (1968) Antimicrobials from plant tissue cultures. Llyodia, 31, 180-189.
72. Bonhomme, V.; Laurain-Mattar, D.; Lacoux, J.; Fliniaux, M-A. and Jacquin-Dubreuil, A. (2000) Tropane alkaloid production by hairy roots of Atropa belladonna obtained after transformation with Agrobacterium rhizogenes 15834 and Agrobacterium tumefaciens containing rol A, B, C genes only. J. Biotechnol., 81(2-3), 151-158.
73. Saha, P.; Chakraborti, D.; Sarkar, A.; Dutta, I.; Basu, D. and Das, S. (2007) Characterization of vascular-specific RSs1 and rolC promoters for their utilization in engineering plants to develop resistance against hemipteran insect pests. Planta, 226(2), 429-442. (Pubitemid 46889521)
74. Sawada, H.; Ieki, H. and Matsuda, I. (1995) PCR detection of Ti and Ri plasmids from phytopathogenic Agrobacterium strains. Appl. Environ. Microbiol., 61(2), 828-831.