Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6519-6523

  Berger, Dan M ^a   Torres, Nancy ^a   Dutia, Minu ^a   Powell, Dennis ^a   Ciszewski, Greg ^a   Gopalsamy, Ariamala ^a   Levin, Jeremy I ^a   Kim, Kyung Hee ^a   Xu, Weixin ^b   Wilhelm, James ^b   Hu, YongBo ^b   Collins, Karen ^a   Feldberg, Larry ^a   Kim, Steven ^a   Frommer, Eileen ^a   Wojciechowicz, Donald ^a   Mallon, Robert ^a  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

Inhibitor; Kinase; Pyrazolo 1,5 a pyrimidine; Raf

Indexed keywords

B RAF KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRAZOLO[1,5 A]PYRIMIDINE DERIVATIVE;

ARTICLE; CELL ACTIVITY; CHEMICAL BINDING; HUMAN; HUMAN CELL; HYDROGEN BOND; SIGNAL TRANSDUCTION; SOLUBILITY; SUZUKI REACTION; X RAY CRYSTALLOGRAPHY;

BENZAMIDES; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; PYRAZOLES; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 71749117560     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.049     Document Type: Article

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