Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 23, 2009, Pages 6582-6584

  Chennamaneni, Naveen Kumar ^a   Arif, Jenifer ^a   Buckner, Frederick S ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Anti parasite therapeutics; Chagas disease; Enzyme inhibitors; Lanosterol 14 demethylase; Sterol biosynthesis

Indexed keywords

DRUG ANALOG; ISOQUINOLINE DERIVATIVE; POSACONAZOLE; TIPIFARNIB;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CHAGAS DISEASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HOST CELL; MAMMAL; MOUSE; NONHUMAN; TRYPANOSOMA CRUZI; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CHAGAS DISEASE; DRUG EVALUATION, PRECLINICAL; MICE; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; QUINOLONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

MAMMALIA; TRYPANOSOMA CRUZI;

EID: 71749114204     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.10.029     Document Type: Article

References (5)

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