Impact of xenon anaesthesia in isolated cardiopulmonary bypass on very early leucocyte and platelet activation and clearance: A randomized, controlled study

British Journal of Anaesthesia

Volumn 103, Issue 6, 2009, Pages 805-810

  Saravanan, P ^a,c   Exley, A R ^b   Valchanov, K ^c   Casey, N D ^d,e   Falter, F ^c  

^a BLACKPOOL TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b Department of Pathology   (United Kingdom)

^c Department of Anaesthesia and Intensive Care Medicine ^*  (United Kingdom)

^d PAPWORTH HOSPITAL   (United Kingdom)

^e BC CHILDREN S HOSPITAL   (Canada)

Author keywords

Blood, neutrophils; Blood, platelets; Heart, cardiopulmonary bypass; Immune response, suppression; Special drugs, xenon

Indexed keywords

BIOLOGICAL MARKER; HEMOGLOBIN; OXYGEN; XENON;

ANESTHESIA; ARTICLE; BLOOD SAMPLING; CARDIOPULMONARY BYPASS; COMPLEX FORMATION; CONTROLLED STUDY; DRUG EFFICACY; HEMOGLOBIN DETERMINATION; HUMAN; LEUKOCYTE ACTIVATION; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MONOCYTE; NEUTROPHIL COUNT; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE COUNT;

EID: 71749112579     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aep297     Document Type: Article

References (30)

1. Wan S, LeClerc JL, Vincent JL. Inflammatory response to cardiopulmonary bypass: Mechanisms involved and possible therapeutic strategies. Chest 1997; 112: 676-92
2. Rinder C. Cellular inflammatory response and clinical outcome in cardiac surgery. Curr Opin Anaesthesiol 2006; 19: 65-8
3. Murkin JM. Etiology and incidence of brain dysfunction after cardiac surgery. J Cardiothorac Vasc Anesth 1999; 13: 12-7
4. Taylor KM. Central nervous system effects of cardiopulmonary bypass. Ann Thorac Surg 1998; 66: S20-4
5. Rinder CS, Bonan JL, Rinder HM, Mathew J, Hines R, Smith BR. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992; 79: 1201-5
6. Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: Studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 2001; 104: 1533-7
7. Nakamura K, Ueno T, Yamamoto H, Iguro Y, Yamada K, Sakata R. Relationship between cerebral injury and inflammatory responses in patients undergoing cardiac surgery with cardiopulmonary bypass. Cytokine 2005; 29: 95-104
8. Huo Y, Schober A, Forlow SB, et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 2003; 9: 61-7
9. Sarma J, Laan CA, Alam S, Jha A, Fox KA, Dransfield I. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 2002; 105: 2166-71
10. Trivedi RA, U-King-IM J, Graves MJ, et al. In vivo detection of macrophages in human carotid atheroma. Temporal dependence of ultrasmall super magnetic particles of iron oxide-enhanced MRI. Stroke 2004; 35: 1631-5
11. Homi HM, Yokoo N, Ma D, et al. The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology 2003; 99: 876-81
12. Ma D, Wilhelm S, Maze M, Franks NP. Neuroprotective and neurotoxic properties of the inert gas, xenon. Br J Anaesth 2002; 89: 739-46 (Pubitemid 35277224)
13. Ma D, Yang H, Lynch J, Franks NP, Maze M, Grocott HP. Xenon attenuates cardiopulmonary bypass-induced neurologic and neurocognitive dysfunction in the rat. Anesthesiology 2003; 98: 690-8
14. Petzelt C, Blom P, Schmehl W, Muller J, Kox WJ. Prevention of neurotoxicity in hypoxic cortical neurons by the noble gas xenon. Life Sci 2003; 72: 1909-18
15. Preckel B, Schlack W, Heibel T, Rutten H. Xenon produces minimal hemodynamic effects in rabbits with chronically compromised left ventricular function. Br J Anaesth 2002; 88: 264-9
16. Schmidt M, Marx T, Kotzerke J, et al. Cerebral and regional organ perfusion in pigs during xenon anaesthesia. Anaesthesia 2001; 56: 1154-9
17. Wilhelm S, Ma D, Maze M, Franks NP. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology 2002; 96: 1485-91
18. de-Rossi LW, Horn NA, Stevanovic A, Buhre W, Hutschenreuter G, Rossaint R. Xenon modulates neutrophil adhesion molecule expression in vitro. Eur J Anaesthesiol 2004; 21: 139-43
19. Macey M, Azam U, McCarthy D, et al. Evaluation of the anticoagulants EDTA and citrate, theophylline, adenosine and dipyridamole (CTAD) for assessing the platelet activation on ADVIA 120 Haematology system. Clin Chem 2002; 48: 891-9
20. de Rossi LW, Horn NA, Baumert JA, Gutensohn K, Hutschenreuter G, Rossaint R. Xenon does not affect human platelet function in vitro. Anesth Analg 2001; 93: 635-40
21. Belge K, Dayyani F, Horelt A, et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. J Immunol 2002; 168: 3536-42
22. Bedi A, McBride WT, Armstrong MA, Murray JM, Fee JPH. Xenon has no effect on cytokine balance and adhesion molecule expression within an isolated cardiopulmonary bypass system. Br J Anaesth 2002; 89: 546-50
23. Bhatia VK, Haskard DO. Markers of inflammation in unstable angina. Heart 2001; 85: 603-4
24. Hillis GS, Dalsey WC, Terregino CA, Daskal I, Nangione A. Altered CD18 leukocyte integrin expression and adhesive function in patients with an acute coronary syndrome. Heart 2001; 85: 702-4
25. Neumann FJ, Marx N, Gawaz M, et al. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation 1997; 95: 2387-94 (Pubitemid 27224733)
26. Tacke F, Alvarez D, Kaplan TJ, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 2007; 117: 185-94
27. Clark JA, Ma D, Homi HM, Maze M, Grocott HP. Xenon and the inflammatory response to cardiopulmonary bypass in the rat. J Cardiothorac Vasc Anesth 2005; 19: 488-93
28. Rinder CS, Rinder HM, Smith BR, et al. Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation. J Clin Invest 1995; 96: 1564-72
29. Rinder CS, Rinder HM, Smith MJ, et al. Antithrombin reduces monocyte and neutrophil CD11b up regulation in addition to blocking platelet activation during extracorporeal circulation. Transfusion 2006; 46: 1130-7
30. Mathew JP, Podgoreanu MV, Grocott HP, et al. Genetic Variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery. J Am Coll Cardiol 2007; 49: 1934-42