Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1793, Issue 12, 2009, Pages 1811-1818

  Cole, Eric T ^a   Zhan, Yu ^a   Abi Saab, Widian F ^a   Korchnak, Amanda C ^a   Ashburner, Brian P ^a   Chadee, Deborah N ^a  

^a UNIVERSITY OF TOLEDO   (United States)

Author keywords

Apoptosis; IKK; MLK3; NF B

Indexed keywords

ETOPOSIDE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MIXED LINEAGE KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SHORT HAIRPIN RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL DEATH; CELL PROTECTION; CELL STRAIN 3T3; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME INACTIVATION; ENZYME REGULATION; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WILD TYPE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; ETOPOSIDE; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; NIH 3T3 CELLS; POLY(ADP-RIBOSE) POLYMERASES;

MURINAE;

EID: 71749108214     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2009.09.014     Document Type: Article

References (29)

1. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
2. Gallo K.A., and Johnson G.L. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat. Rev. Mol. Cell Biol. 3 (2002) 663-672
3. Tibbles L.A., Ing Y.L., Kiefer F., Chan J., Iscove N., Woodgett J.R., and Lassam N.J. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J. 15 (1996) 7026-7035
4. Rana A., Gallo K., Godowski P., Hirai S., Ohno S., Zon L., Kyriakis J.M., and Avruch J. The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem. 271 (1996) 19025-19028
5. Chadee D.N., and Kyriakis J.M. A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation. Cell Cycle 3 (2004) 1227-1229
6. Hehner S.P., Hofmann T.G., Ushmorov A., Dienz O., Wing-Lan Leung I., Lassam N., Scheidereit C., Droge W., and Schmitz M.L. Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex. Mol. Cell. Biol. 20 (2000) 2556-2568
7. Sathyanarayana P., Barthwal M.K., Lane M.E., Acevedo S.F., Skoulakis E.M., Bergmann A., and Rana A. Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling. Biochim. Biophys. Acta 1640 (2003) 77-84
8. Sathyanarayana P., Barthwal M.K., Kundu C.N., Lane M.E., Bergmann A., Tzivion G., and Rana A. Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Mol. Cell 10 (2002) 1527-1533
9. Kim K.Y., Kim B.C., Xu Z., and Kim S.J. Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells. J. Biol. Chem. 279 (2004) 29478-29484
10. Chadee D.N., and Kyriakis J.M. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. Nat. Cell Biol. 6 (2004) 770-776
11. Swenson K.I., Winkler K.E., and Means A.R. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. Mol. Biol. Cell 14 (2003) 156-172
12. Brancho D., Ventura J.J., Jaeschke A., Doran B., Flavell R.A., and Davis R.J. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol. Cell. Biol. 25 (2005) 3670-3681
13. Xu Z., Maroney A.C., Dobrzanski P., Kukekov N.V., and Greene L.A. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Mol. Cell. Biol. 21 (2001) 4713-4724
14. Mota M., Reeder M., Chernoff J., and Bazenet C.E. Evidence for a role of mixed lineage kinases in neuronal apoptosis. J. Neurosci. 21 (2001) 4949-4957
15. Maroney A.C., Finn J.P., Connors T.J., Durkin J.T., Angeles T., Gessner G., Xu Z., Meyer S.L., Savage M.J., Greene L.A., Scott R.W., and Vaught J.L. Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J. Biol. Chem. 276 (2001) 25302-25308
16. Barthwal M.K., Sathyanarayana P., Kundu C.N., Rana B., Pradeep A., Sharma C., Woodgett J.R., and Rana A. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J. Biol. Chem. 278 (2003) 3897-3902
17. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev. 18 (2004) 2195-2224
18. Ghosh S. Regulation of inducible gene expression by the transcription factor NF-kappaB. Immunol. Res. 19 (1999) 183-189
19. Ghosh S., and Karin M. Missing pieces in the NF-kappaB puzzle. Cell 109 (2002) S81-S96 Suppl
20. Woronicz J.D., Gao X., Cao Z., Rothe M., and Goeddel D.V. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278 (1997) 866-869
21. Zhao Q., and Lee F.S. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta. J. Biol. Chem. 274 (1999) 8355-8358
22. Nakano H., Shindo M., Sakon S., Nishinaka S., Mihara M., Yagita H., and Okumura K. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 3537-3542
23. Chadee D.N., Xu D., Hung G., Andalibi A., Lim D.J., Luo Z., Gutmann D.H., and Kyriakis J.M. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 4463-4468
24. Sammons M., Wan S.S., Vogel N.L., Mientjes E.J., Grosveld G., and Ashburner B.P. Negative regulation of the RelA/p65 transactivation function by the product of the DEK proto-oncogene. J. Biol. Chem. 281 (2006) 26802-26812
25. Cai D., Frantz J.D., Tawa Jr. N.E., Melendez P.A., Oh B.C., Lidov H.G., Hasselgren P.O., Frontera W.R., Lee J., Glass D.J., and Shoelson S.E. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 119 (2004) 285-298
26. Sakurai H., Chiba H., Miyoshi H., Sugita T., and Toriumi W. IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem. 274 (1999) 30353-30356
27. Roux P.P., Dorval G., Boudreau M., Angers-Loustau A., Morris S.J., Makkerh J., and Barker P.A. K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK. J. Biol. Chem. 277 (2002) 49473-49480
28. Karpinich N.O., Tafani M., Rothman R.J., Russo M.A., and Farber J.L. The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J. Biol. Chem. 277 (2002) 16547-16552
29. Liu Z.G., Hsu H., Goeddel D.V., and Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell 87 (1996) 565-576