Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation

Journal of Biological Chemistry

Volumn 284, Issue 49, 2009, Pages 34005-34018

  Ralat, Luis A ^a   Ren, Min ^a   Schilling, Alexander B ^b   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIPHASIC; CATALYTIC ACTIVITY; CATALYTIC CENTER; FOURIER TRANSFORM ION CYCLOTRON RESONANCE; INHIBITORY RESPONSE; INSULIN-DEGRADING ENZYMES; LONG DISTANCE INTERACTIONS; MICROGLIAL CELLS; MOLECULAR BASIS; MUTATIONAL ANALYSIS; NITROGEN SPECIES; OXIDATIVE BURSTS; PEPTIDE MASS FINGERPRINTING; REACTIVE OXYGEN; REACTIVE OXYGEN AND NITROGEN SPECIES; S-NITROSOGLUTATHIONE;

AMINES; BIOMIMETICS; DEGRADATION; ENZYMES; HYDROGEN PEROXIDE; INSULIN; MASS SPECTROMETRY; OLIGOMERIZATION; OXIDATION; OXYGEN; PEPTIDES; PHOTODEGRADATION; ZINC;

INTEGRODIFFERENTIAL EQUATIONS;

AMYLOID BETA PROTEIN; CYSTEINE; HYDROGEN PEROXIDE; INSULINASE; REACTIVE OXYGEN METABOLITE; S NITROSOGLUTATHIONE; ZINC BINDING PROTEIN;

ARTICLE; CATALYSIS; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME RELEASE; ENZYME STABILITY; ENZYME STRUCTURE; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MICROGLIA; MUTATIONAL ANALYSIS; NITROSYLATION; NONHUMAN; OLIGOMERIZATION; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; CYSTEINE; ESCHERICHIA COLI; HUMANS; HYDROGEN PEROXIDE; INSULYSIN; MICE; MICROGLIA; MODELS, BIOLOGICAL; NITROGEN; OXYGEN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RESPIRATORY BURST; S-NITROSOGLUTATHIONE;

EID: 71749105343     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.030627     Document Type: Article

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