High lipoprotein(a) level promotes both coronary atherosclerosis and myocardial infarction: A path analysis using a large number of autopsy cases

Heart

Volumn 95, Issue 24, 2009, Pages 1997-2002

  Sawabe, Motoji ^a   Tanaka, N ^b   Nakahara, K ^c   Hamamatsu, A ^a   Chida, K ^a   Arai, T ^a   Harada, K ^a   Inamatsu, T ^a   Ozawa, T ^a   Naka, M M ^d   Matsushita, S ^a  

^a Tokyo Metropolitan Institute of Gerontology   (Japan)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c NATIONAL HOSPITAL ORGANIZATION NAGASAKI MEDICAL CENTER   (Japan)

^d JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN A;

ARTICLE; AUTOPSY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY THROMBOSIS; DIABETES MELLITUS; DISEASE SEVERITY; HEART INFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPOPROTEINEMIA; HYPERTENSION; IMMUNOASSAY; LATEX ENHANCED TURBIDIMETRIC IMMUNOASSAY; LIPOPROTEIN BLOOD LEVEL; MEDICAL RECORD REVIEW; PATH ANALYSIS; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR;

ACUTE DISEASE; AGED, 80 AND OVER; AUTOPSY; CHRONIC DISEASE; CORONARY ARTERY DISEASE; CORONARY THROMBOSIS; FEMALE; HUMANS; HYPERLIPOPROTEINEMIAS; LIPOPROTEIN(A); MALE; MYOCARDIAL INFARCTION; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 71749097469     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/hrt.2008.160879     Document Type: Article

References (34)

1. Fuster V, Moreno PR, Fayad ZA, et al. Atherothrombosis and high-risk plaque: Part I: Evolving concepts. J Am Coll Cardiol 2005;46:937-954 (Pubitemid 41316498)
2. Bennet A, Di Angelantonio E, Erqou S, et al. Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data. Arch Intern Med 2008;168:598-608.
3. Danesh J, Collins R, Peto R. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation 2000;102:1082-1085
4. Kamstrup PR, Benn M, Tybærg-Hansen A, et al. Extreme lipoprotein(a) levels and risk of myocardial infarction in the general population: the Copenhagen City Heart Study. Circulation 2008;117:176-184
5. Seman LJ, DeLuca C, Jenner JL, et al. Lipoprotein(a)-cholesterol and coronary heart disease in the Framingham Heart Study. Clin Chem 1999;45:1039-1046 (Pubitemid 29340541)
6. Suk Danik J, Rifai N, Buring JE, et al. Lipoprotein(a), measured with an assay independent of apolipoprotein(a) isoform size, and risk of future cardiovascular events among initially healthy women. JAMA 2006;296:1363-1370 (Pubitemid 44427422)
7. Boerwinkle E, Leffert CC, Lin J, et al. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 1992;90:52-60.
8. Berglund L, Ramakrishnan R. Lipoprotein(a): an elusive cardiovascular risk factor. Arterioscler Thromb Vasc Biol 2004;24:2219-2226 (Pubitemid 39658021)
9. Koschinsky ML. Novel insights into Lp(a) physiology and pathogenicity: more questions than answers? Cardiovasc Hematol Disord Drug Targets 2006;6:267-278
10. Deb A, Caplice NM. Lipoprotein(a): new insights into mechanisms of atherogenesis and thrombosis. Clin Cardiol 2004;27:258-264 (Pubitemid 38703073)
11. Lippi G, Guidi G. Lipoprotein(a): from ancestral benefit to modern pathogen? QJM 2000;93:75-84.
12. Ducas J, Silversides C, Dembinski TC, et al. Apolipoprotein(a) phenotypes predict the severity of coronary artery stenosis. Clin Invest Med 2002;25:74-82. (Pubitemid 34969886)
13. Glader CA, Birgander LS, Stenlund H, et al. Is lipoprotein(a) a predictor for survival in patients with established coronary artery disease? Results from a prospective patient cohort study in northern Sweden. J Intern Med 2002;252:27-35. (Pubitemid 34743907)
14. Govindaraju V, Neelam, Manjunath CN, et al. Lipoprotein (a) in coronary artery disease in Indian population. J Indian Med Assoc 2003;101:458-60, 462. (Pubitemid 38035951)
15. Moon JY, Kwon HM, Kwon SW, et al. Lipoprotein(a) and LDL particle size are related to the severity of coronary artery disease. Cardiology 2007;108:282-289
16. Sofi F, Marcucci R, Abbate R, et al. Lipoprotein (a) and venous thromboembolism in adults: a meta-analysis. Am J Med 2007;120:728-733 (Pubitemid 47189658)
17. Tsimikas S, Brilakis ES, Miller ER, et al. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med 2005;353:46-57. (Pubitemid 41007806)
18. Tsimikas S, Tsironis LD, Tselepis AD. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler Thromb Vasc Biol 2007;27:2094-2099 (Pubitemid 350287235)
19. Sawabe M, Arai T, Kasahara I, et al. Developments of geriatric autopsy database and Internet-based database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP). Mech Ageing Dev 2004;125:547-552 (Pubitemid 39149998)
20. Sawabe M, Hamamatsu A, Chida K, et al. Elderly patients with minimal common carotid atherosclerosis not infrequently have severe coronary atherosclerosis and myocardial infarction. Circ J 2008;72:1946-1952
21. Panteghini M, Pagani F. Pre-analytical, analytical and biological sources of variation of lipoprotein(a). Eur J Clin Chem Clin Biochem 1993;31:23-28 (Pubitemid 23065619)
22. Craig WY, Poulin SE, Forster NR, et al. Effect of sample storage on the assay of lipoprotein(a) by commercially available radial immunodiffusion and enzyme-linked immunosorbent assay kits. Clin Chem 1992;38:550-553
23. Simó JM, Camps J, Vilella E, et al. Instability of lipoprotein(a) in plasma stored at 270uC: effects of concentration, apolipoprotein(a) genotype, and donor cardiovascular disease. Clin Chem 2001;47:1673-1678 (Pubitemid 32781582)
24. Marcovina SM, Albers JJ, Scanu AM, et al. Use of a reference material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate analytical methods for the determination of plasma lipoprotein(a). Clin Chem 2000;46:1956-1967.
25. Chida K, Ohkawa S, Watanabe C, et al. A morphological study of the normally aging heart. Cardiovasc Pathol 1994;3:1-7. (Pubitemid 24087029)
26. De Torbal A, Boersma E, Kors JA, et al. Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam Study. Eur Heart J 2006;27:729-736
27. Wright S. The method of path coefficients. Ann Math Stat 1934;5:161-215.
28. LaCroix AZ, Omenn GS. Older adults and smoking. Clin Geriatr Med 1992;8:69-87.
29. Iso H, Date C, Yamamoto A, et al. Smoking cessation and mortality from cardiovascular disease among Japanese men and women: the JACC Study. Am J Epidemiol 2005;161:170-179 (Pubitemid 40096792)
30. Sawabe M, Arai T, Kasahara I, et al. Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: a pathological study of 1074 consecutive autopsy cases. Atherosclerosis 2006;186:374-379
31. Oda K, Tanaka N, Arai T, et al. Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases. Hum Mol Genet 2007;16:592-599 (Pubitemid 46585661)
32. Jenner JL, Ordovas JM, Lamon-Fava S, et al. Effects of age, sex, and menopausal status on plasma lipoprotein(a) levels. The Framingham Offspring Study. Circulation 1993;87:1135-1141
33. Miyao M, Araki A, Hattori A, et al. Lipoprotein(a) as a risk factor for cardiovascular disease in elderly patients with diabetes. Nippon Ronen Igakkai Zasshi 1997;34:185-191
34. Kostner KM, Kostner GM. Therapy of hyper-Lp(a). Handb Exp Pharmacol 2005;170:519-536