A peptide based on the pore-forming domain of pro-apoptotic poliovirus 2B viroporin targets mitochondria

Biochimica et Biophysica Acta - Biomembranes

Volumn 1798, Issue 1, 2010, Pages 52-58

  Madan, Vanesa ^a   Sánchez Martínez, Silvia ^b   Carrasco, Luis ^a   Nieva, José L ^b  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Enterovirus 2B; Pore forming peptide; Protein lipid interaction; Viral protein induced apoptosis; Viroporin

Indexed keywords

POLIOVIRUS 2B VIROPORIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL ORGANELLE; CELL STRUCTURE; CONTROLLED STUDY; KIDNEY CELL; LIPID BILAYER; MITOCHONDRION; NONHUMAN; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; PROTEIN TRANSPORT; VIRUS CELL INTERACTION; VIRUS CULTURE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BINDING SITES; CELL LINE; CELL MEMBRANE PERMEABILITY; ENDOCYTOSIS; FLOW CYTOMETRY; HOST-PATHOGEN INTERACTIONS; HUMANS; MEMBRANE LIPIDS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PEPTIDES; POLIOVIRUS; PROTEIN BINDING; VIRAL NONSTRUCTURAL PROTEINS;

ENTEROVIRUS; POLIOVIRUS;

EID: 71749091651     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2009.10.013     Document Type: Article

References (34)

1. Carrasco L., Perez L., Irurzun A., Martinez-Abarca F., Rodriguez P., Guinea R., Castrillo J.L., Sanz M.A., and Ayala M.J. In: Carrasco L., Sonenberg N., and Wimmer E. (Eds). Regulation of gene expression in animal viruses (1993), Plenum Press, London 283-305
2. Carrasco L., Guinea R., Irurzun A., and Barco A. In: Semler B.L., and Wimmer E. (Eds). Molecular biology of picornavirus (2002), ASM Press, Washington 337-354
3. Gonzalez M.E., and Carrasco L. Viroporins. FEBS Lett. 552 (2003) 28-34
4. Madan V., Garcia Mde J., Sanz M.A., and Carrasco L. Viroporin activity of murine hepatitis virus E protein. FEBS Lett. 579 (2005) 3607-3612
5. Nieva J.L., Agirre A., Nir S., and Carrasco L. Mechanisms of membrane permeabilization by picornavirus 2B viroporin. FEBS Lett. 552 (2003) 68-73
6. van Kuppeveld F.J., Melchers W.J., Kirkegaard K., and Doedens J.R. Structure-function analysis of coxsackie B3 virus protein 2B. Virology 227 (1997) 111-118
7. Agirre A., Barco A., Carrasco L., and Nieva J.L. Viroporin-mediated membrane permeabilization. Pore formation by nonstructural poliovirus 2B protein. J. Biol. Chem. 277 (2002) 40434-40441
8. Madan V., Castello A., and Carrasco L. Viroporins from RNA viruses induce caspase-dependent apoptosis. Cell Microbiol. 10 (2008) 437-451
9. Boya P., Roumier T., Andreau K., Gonzalez-Polo R.A., Zamzami N., Castedo M., and Kroemer G. Mitochondrion-targeted apoptosis regulators of viral origin. Biochem. Biophys. Res. Commun. 304 (2003) 575-581
10. Boya P., Pauleau A.L., Poncet D., Gonzalez-Polo R.A., Zamzami N., and Kroemer G. Viral proteins targeting mitochondria: controlling cell death. Biochim. Biophys. Acta 1659 (2004) 178-189
11. van Kuppeveld F.J., Galama J.M., Zoll J., van den Hurk P.J., and Melchers W.J. Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication. J. Virol. 70 (1996) 3876-3886
12. de Jong A.S., Melchers W.J., Glaudemans D.H., Willems P.H., and van Kuppeveld F.J. Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. J. Biol. Chem. 279 (2004) 19924-19935
13. Sanchez-Martinez S., Huarte N., Maeso R., Madan V., Carrasco L., and Nieva J.L. Functional and structural characterization of 2B viroporin membranolytic domains. Biochemistry 47 (2008) 10731-10739
14. Madan V., Sanchez-Martinez S., Vedovato N., Rispoli G., Carrasco L., and Nieva J.L. Plasma membrane-porating domain in poliovirus 2B protein. A short peptide mimics viroporin activity. J. Mol. Biol. 374 (2007) 951-964
15. Matsuzaki K. Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes. Biochim. Biophys. Acta 1462 (1999) 1-10
16. Shai Y. Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim. Biophys. Acta 1462 (1999) 55-70
17. Chan D.I., Prenner E.J., and Vogel H.J. Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action. Biochim. Biophys. Acta 1758 (2006) 1184-1202
18. Henriques S.T., Melo M.N., and Castanho M.A. Cell-penetrating peptides and antimicrobial peptides: how different are they. Biochem. J. 399 (2006) 1-7
19. Huang H.W. Molecular mechanism of antimicrobial peptides: the origin of cooperativity. Biochim. Biophys. Acta 1758 (2006) 1292-1302
20. Pokorny A., and Almeida P.F. Kinetics of dye efflux and lipid flip-flop induced by delta-lysin in phosphatidylcholine vesicles and the mechanism of graded release by amphipathic, alpha-helical peptides. Biochemistry 43 (2004) 8846-8857
21. Rausch J.M., Marks J.R., Rathinakumar R., and Wimley W.C. Beta-sheet pore-forming peptides selected from a rational combinatorial library: mechanism of pore formation in lipid vesicles and activity in biological membranes. Biochemistry 46 (2007) 12124-12139
22. Morris M.C., Deshayes S., Heitz F., and Divita G. Cell-penetrating peptides: from molecular mechanisms to therapeutics. Biol. Cell 100 (2008) 201-217
23. Chan Y.R., and Gallo R.L. PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas). J. Biol. Chem. 273 (1998) 28978-28985
24. Takeshima K., Chikushi A., Lee K.K., Yonehara S., and Matsuzaki K. Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes. J. Biol. Chem. 278 (2003) 1310-1315
25. Lau Y.E., Rozek A., Scott M.G., Goosney D.L., Davidson D.J., and Hancock R.E. Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun. 73 (2005) 583-591
26. Tomasinsig L., Skerlavaj B., Papo N., Giabbai B., Shai Y., and Zanetti M. Mechanistic and functional studies of the interaction of a proline-rich antimicrobial peptide with mammalian cells. J. Biol. Chem. 281 (2006) 383-391
27. Ellens H., Bentz J., and Szoka F.C. H+- and Ca2+-induced fusion and destabilization of liposomes. Biochemistry 24 (1985) 3099-3106
28. Madan V., Sanz M.A., and Carrasco L. Requirement of the vesicular system for membrane permeabilization by Sindbis virus. Virology 332 (2005) 307-315
29. Barco A., and Carrasco L. A human virus protein, poliovirus protein 2BC, induces membrane proliferation and blocks the exocytic pathway in the yeast Saccharomyces cerevisiae. EMBO J. 14 (1995) 3349-3364
30. Matsuzaki K., Murase O., Fujii N., and Miyajima K. Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore. Biochemistry 34 (1995) 6521-6526
31. Gomara M.J., Nir S., and Nieva J.L. Effects of sphingomyelin on melittin pore formation. Biochim. Biophys. Acta 1612 (2003) 83-89
32. Allende D., Simon S.A., and McIntosh T.J. Melittin-induced bilayer leakage depends on lipid material properties: evidence for toroidal pores. Biophys. J. 88 (2005) 1828-1837
33. Comeau J.W., Costantino S., and Wiseman P.W. A guide to accurate fluorescence microscopy colocalization measurements. Biophys. J. 91 (2006) 4611-4622
34. Sanz M.A., Madan V., Carrasco L., and Nieva J.L. Interfacial domains in Sindbis virus 6K protein. Detection and functional characterization. J. Biol. Chem. 278 (2003) 2051-2057