Peptide inhibitors of HIV-1 integrase: From mechanistic studies to improved lead compounds

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 22, 2009, Pages 7635-7642

  Maes, Michal ^a   Levin, Aviad ^a   Hayouka, Zvi ^a   Shalev, Deborah E ^a   Loyter, Abraham ^a   Friedler, Assaf ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

HIV 1; Inhibitors; Integrase; Peptides

Indexed keywords

INTEGRASE; INTEGRASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; VIRUS DNA CELL DNA INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; BINDING SITES; DRUG DESIGN; HELA CELLS; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 71749090050     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.09.053     Document Type: Article

References (39)

1. Craigie R. J. Biol. Chem. 276 (2001) 23213
2. Hazuda D.J., Young S.D., Guare J.P., Anthony N.J., Gomez R.P., Wai J.S., Vacca J.P., Handt L., Motzel S.L., Klein H.J., Dornadula G., Danovich R.M., Witmer M.V., Wilson K.A., Tussey L., Schleif W.A., Gabryelski L.S., Jin L., Miller M.D., Casimiro D.R., Emini E.A., and Shiver J.W. Science 305 (2004) 528
3. Lataillade M., and Kozal M.J. AIDS Patient Care STDS 20 (2006) 489
4. Pommier Y., Johnson A.A., and Marchand C. Nat. Rev. Drug Disc. 4 (2005) 236
5. Engelman A., Mizuuchi K., and Craigie R. Cell 67 (1991) 1211
6. Guiot E., Carayon K., Delelis O., Simon F., Tauc P., Zubin E., Gottikh M., Mouscadet J.F., Brochon J.C., and Deprez E. J. Biol. Chem. 281 (2006) 22707
7. Chen A., Weber I.T., Harrison R.W., and Leis J. J. Biol. Chem. 281 (2006) 4173
8. Deprez E., Tauc P., Leh H., Mouscadet J.F., Auclair C., and Brochon J.C. Biochemistry 39 (2000) 9275
9. Deprez E., Tauc P., Leh H., Mouscadet J.F., Auclair C., Hawkins M.E., and Brochon J.C. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 10090
10. Faure A., Calmels C., Desjobert C., Castroviejo M., Caumont-Sarcos A., Tarrago-Litvak L., Litvak S., and Parissi V. Nucleic Acids Res. 33 (2005) 977
11. Cai M., Zheng R., Caffrey M., Craigie R., Clore G.M., and Gronenborn A.M. Nat. Struct. Biol. 4 (1997) 567
12. Dyda F., Hickman A.B., Jenkins T.M., Engelman A., Craigie R., and Davies D.R. Science 266 (1994) 1981
13. Lodi P.J., Ernst J.A., Kuszewski J., Hickman A.B., Engelman A., Craigie R., Clore G.M., and Gronenborn A.M. Biochemistry 34 (1995) 9826
14. de Soultrait V.R., Caumont A., Parissi V., Morellet N., Ventura M., Lenoir C., Litvak S., Fournier M., and Roques B. J. Mol. Biol. 318 (2002) 45
15. Sourgen F., Maroun R.G., Frere V., Bouziane M., Auclair C., Troalen F., and Fermandjian S. Eur. J. Biochem. 240 (1996) 765
16. Zhao L., O'Reilly M.K., Shultz M.D., and Chmielewski J. Bioorg. Med. Chem. Lett. 13 (2003) 1175
17. Armon-Omer A., Levin A., Hayouka Z., Butz K., Hoppe-Seyler F., Loya S., Hizi A., Friedler A., and Loyter A. J. Mol. Biol. 376 (2008) 971
18. Hayouka Z., Rosenbluh J., Levin A., Loya S., Lebendiker M., Veprintsev D., Kotler M., Hizi A., Loyter A., and Friedler A. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 8316
19. Hayouka Z., Rosenbluh J., Levin A., Maes M., Loyter A., and Friedler A. Biopolymers 90 (2008) 481
20. Rosenbluh J., Hayouka Z., Loya S., Levin A., Armon-Omer A., Britan E., Hizi A., Kotler M., Friedler A., and Loyter A. J. Biol. Chem. 282 (2007) 15743
21. Hopkins A.L., and Groom C.R. Nat. Rev. Drug Disc. 1 (2002) 727
22. Keller M., and Miller A.D. Bioorg. Med. Chem. Lett. 11 (2001) 857
23. Schmiedeberg N., and Kessler H. Org. Lett. 4 (2002) 59
24. Garcia-Martin F., Quintanar-Audelo M., Garcia-Ramos Y., Cruz L.J., Gravel C., Furic R., Cote S., Tulla-Puche J., and Albericio F. J. Comb. Chem. 8 (2006) 213
25. Garcia-Martin F., White P., Steinauer R., Cote S., Tulla-Puche J., and Albericio F. Biopolymers 84 (2006) 566
26. Marani M.M., Paradis-Bas M., Tulla-Puche J., Cote S., Camperi S.A., Cascone O., and Albericio F. J. Comb. Chem. 9 (2007) 395
27. Kimpton J., and Emerman M. J. Virol. 66 (1992) 2232
28. Cherepanov P., Ambrosio A.L., Rahman S., Ellenberger T., and Engelman A. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 17308
29. Levin A., Hayouka Z., Helfer M., Brack-Werner R., Friedler A., and Loyter A. PLoS ONE 4 (2009) e4155
30. Jenkins T.M., Engelman A., Ghirlando R., and Craigie R. J. Biol. Chem. 271 (1996) 7712
31. Chang C.D., and Meienhofer J. Int. J. Pept. Protein Res. 11 (1978) 246
32. Weber P.J., Bader J.E., Folkers G., and Beck-Sickinger A.G. Bioorg. Med. Chem. Lett. 8 (1998) 597
33. Friedler A., Hansson L.O., Veprintsev D.B., Freund S.M., Rippin T.M., Nikolova P.V., Proctor M.R., Rudiger S., and Fersht A.R. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 937
34. Friedler A., Veprintsev D.B., Rutherford T., von Glos K.I., and Fersht A.R. J. Biol. Chem. 280 (2005) 8051
35. Bax A. J. Magn. Reson. 65 (1985) 142
36. Kumar A., Wagner G., Ernst R.R., and Wuthrich K. Biochem. Biophys. Res. Commun. 96 (1980) 1156
37. Macura S., and Ernst R.R. Mol. Phys. 41 (1980) 95
38. Liu M.L., Mao X.A., Ye C.H., Huang H., Nicholson J.K., and Lindon J.C. J. Magn. Reson. 132 (1998) 125
39. Wüthrich, K. NMR of Proteins and Nucleic Acids; John Wiley and Sons, New York, 1986.