The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function

British Journal of Pharmacology

Volumn 158, Issue 8, 2009, Pages 2046-2056

  Ni, Jia ^a   Zhu, Yi Na ^a   Zhong, Xiang Gen ^a   Ding, Yu ^a   Hou, Li Fei ^a   Tong, Xian Kun ^a   Tang, Wei ^a   Ono, Shiro ^b   Yang, Yi Fu ^a,c   Zuo, Jian Ping ^a,c  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b OSAKA OHTANI UNIVERSITY   (Japan)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

CCR5; Chemokine; CXCR3; Experimental autoimmune encephalomyelitis; T cell migration

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; N [4 [[[6,7 DIHYDRO 2 (4 METHYLPHENYL) 5H BENZOCYCLOHEPTEN 8 YL]CARBONYL]AMINO]BENZYL] N,N DIMETHYL 2H TETRAHYDROPYRAN 4 AMINIUM CHLORIDE; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNIZATION; INFLAMMATION; INFLAMMATORY CELL; MORBIDITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; T LYMPHOCYTE;

AMIDES; ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; MICE; MICE, INBRED C57BL; POLYMERASE CHAIN REACTION; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CCR5; RECEPTORS, CXCR3; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; T-LYMPHOCYTES;

EID: 71649105491     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00528.x     Document Type: Article

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