Modeling pharmaceutical powder-flow performance using particle-size distribution data

Pharmaceutical Technology

Volumn 33, Issue 3, 2009, Pages 126-134

  Mullarney, Matthew P ^a   Leyva, Norma ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; BULK POWDERS; FLOW PERFORMANCE; MATERIAL CONSUMPTION; PHARMACEUTICAL POWDER; SHEAR CELLS;

SIZE DISTRIBUTION;

LIGHT TRANSMISSION;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; FLOW MEASUREMENT; PARTIAL LEAST SQUARES REGRESSION; PARTICLE SIZE; POWDER; POWDER FLOW TEST; SHEAR STRESS;

EID: 71649103150     PISSN: 15432521     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. E.N. Hiestand, "Mechanics and Physical Principles for Powders and Compacts" (SSCI Inc., West Lafayette, IN, 2002), p. 110.
2. J. Staniforth, "Powder Flow," in Pharmaceutics: The Science of Dosage Form Design, M.E. Aulton, Ed. (Churchill Livingstone, Edinburgh, UK, 2002) pp. 197-210.
3. G.E. Amidon and M.E. Houghton, "Powder Flow Testing in Pre-formulation and Formulation Development," Pharma. Manuf., 2 (7) 21-31 (1985).
4. A.W. Jenike, "Storage and Flow of Solids," in Utah Engineering Experiment Station Bulletin 123, 16th ed., (University of Utah, Salt Lake City, UT, 1964).
5. T. Kohler and H. Schubert, "Influence of Particle Size Distribution on the Flow Behavior of Fine Powders," Part. Syst. Charact. 8 (1-4), 101-104 (1991).
6. F. Podczeck and Y. Miah, "The Influence of Particle Size and Shape on the Angle of Internal Friction and the Flow Factor of Unlubricated and Lubricated Powders," Int. J. Pharm. 144 (2) 187-194 (1996).
7. L. Breiman et al., "Classification and Regression Trees" (Chapman & Hall/CRC, Boca Raton, FL, 1984).