Rapid high-performance liquid chromatography-tandem mass spectrometry method for simultaneous measurement of venlafaxine and O-desmethylvenlafaxine in human plasma and its application in comparative bioavailability study

Biomedical Chromatography

Volumn 23, Issue 12, 2009, Pages 1300-1307

  Rajasekhar, D ^a,b   Jaswanth Kumar, I ^a,b   Venkateswarlu, P ^a  

^a Department of Chemistry   (India)

^b Wellquest Clinical Research Laboratories   (India)

Author keywords

Human plasma; LC MS MS; Venlafaxine

Indexed keywords

BIOCHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; PLASMA (HUMAN); SOLVENT EXTRACTION;

BIOAVAILABILITY STUDY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HUMAN PLASMAS; INTERNAL STANDARDS; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; MEASUREMENTS OF; SIMULTANEOUS MEASUREMENT; VENLAFAXINE;

MASS SPECTROMETRY;

AMMONIUM ACETATE; DESVENLAFAXINE; FLUOXETINE; METHANOL; TERT BUTYL METHYL ETHER; VENLAFAXINE;

ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SOLVENT EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 71649099283     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1253     Document Type: Article

References (9)

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