Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease

Neuroscience

Volumn 165, Issue 2, 2010, Pages 427-435

  Lecanu, L ^a,b   Rammouz, G ^a   McCourty, A ^a,b   Sidahmed, E K ^b   Greeson, J ^c   Papadopoulos, V ^a,b,d  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c Samaritan Therapeutics   (Canada)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

amyloid; Alzheimer's disease; neurodegeneration; neuroinflammation; neurosteroids

Indexed keywords

22 HYDROXYCHOLESTEROL; AMYLOID BETA PROTEIN; CAPROSPINOL; STEROID; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; COGNITION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG MECHANISM; FOREBRAIN; HIPPOCAMPUS; HISTOLOGY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAZE TEST; MEMORY DISORDER; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SYNTHESIS;

ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; COGNITION DISORDERS; DIOSGENIN; DISEASE MODELS, ANIMAL; GLIOSIS; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY DISORDERS; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROSENCEPHALON; RATS; RATS, LONG-EVANS; SENILE PLAQUES; TAU PROTEINS;

EID: 71549156536     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.10.033     Document Type: Article

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