An Analysis of Efficacy Data from Four Phase III Studies of Botulinum Neurotoxin Type A-ABO for the Treatment of Glabellar Lines

Aesthetic Surgery Journal

Volumn 29, Issue 6 SUPPL., 2009, Pages

  Baumann, Leslie ^a   Brandt, Fredric S ^a   Kane, Michael A C ^a   Donofrio, Lisa M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; PLACEBO;

AFRICAN AMERICAN; ARTICLE; ASIAN; CLINICAL EVALUATION; CLINICAL TRIAL; DATA ANALYSIS; DRUG EFFICACY; ETHNICITY; FACE MUSCLE; FOLLOW UP; GENDER; GLABELLAR LINE; HISPANIC; HUMAN; MEDICAL PHOTOGRAPHY; META ANALYSIS; MULTIPLE CYCLE TREATMENT; MUSCLE MASS; PATIENT ASSESSMENT; PRIORITY JOURNAL; SEX DIFFERENCE; SIDE EFFECT; SYSTEMATIC REVIEW; TACHYPHYLAXIS; TREATMENT RESPONSE; WRINKLE;

ADULT; BOTULINUM TOXIN TYPE A; CLINICAL TRIALS, PHASE III AS TOPIC; FEMALE; HUMANS; MALE; NEUROTOXINS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SEX FACTORS; SKIN AGING; THERAPIES, INVESTIGATIONAL; TIME FACTORS; TREATMENT OUTCOME;

EID: 71549153159     PISSN: 1090820X     EISSN: 1527330X     Source Type: Journal    
DOI: 10.1016/j.asj.2009.09.012     Document Type: Article

References (21)

1. Ascher B., Klap P., Marion M.H., and Chanteloub F. Botulinum toxin in the treatment of frontoglabellar and periorbital wrinkles (in French). Ann Chir Plast Esthet 40 (1995) 67-76
2. Ascher B. Facial rejuvenation by non-endoscopic lifting and botulinum toxin injection. Cahiers Ophthalmol 45 (2000) 25-31
3. Ascher B., Zakine B., Kestemont P., Baspeyras M., Bougara A., and Santini J. A multicenter, randomized, double-blind, placebo-controlled study of efficacy and safety of 3 doses of botulinum toxin A in the treatment of glabellar lines. J Am Acad Dermatol 51 (2004) 223-233
4. Ascher B., Zakine B., Kestemont P., et al. Botulinum toxin A in the treatment of glabellar lines: scheduling the next injection. Aesthet Surg J 25 (2005) 365-375
5. Erian A., and Ionescu N.E. Combination treatment of glabellar rhytids. Int J Cosmet Surg 7 (1999) 14-17
6. Feller G., Bayerl C., Jung E., and Rzany B. Treatment of dynamic facial wrinkles with botulinum toxin type A (Dysport)-a pilot study. Akt Dermatol 26 (2000) 65-69
7. Honeck P., Weiss C., Sterry W., Rzany B., and Gladys study group. Reproducibility of a four-point clinical severity score for glabellar frown lines. Br J Dermatol 149 (2003) 306-310
8. Le Louarn C. Botulinum toxin and facial wrinkles: a new injection procedure [in French]. Ann Chir Plast Esthet 43 (1998) 526-533
9. Lowe N.J. Botulinum toxin type A for facial rejuvenation. United States and United Kingdom perspectives. Dermatol Surg 24 (1998) 1216-1218
10. Lowe P., Patnaik R., and Lowe N. Comparison of two formulations of botulinum toxin type A for the treatment of glabellar lines: a double-blind, randomized study. J Am Acad Dermatol 55 (2006) 975-980
11. Monheit G., Carruthers A., Brandt F., and Rand R. A randomized, double-blind, placebo controlled study of botulinum toxin type A for the treatment of glabellar lines: determination of optimal dose. Dermatol Surg 33 1 spec no (2007) S51-S59
12. Olver J.M. Botulinum toxin A treatment of overactive corrugator supercilii in thyroid eye disease. Br J Ophthalmol 82 (1998) 528-533
13. Rzany B., Dill-Müller D., Grablowitz D., Heckman M., Caird D., and German-Austrian Retrospective Study Group. Repeated botulinum toxin A injections for the treatment of lines in the upper face: a retrospective study of 4,103 treatments in 945 subjects. Dermatol Surg 33 1 spec no (2007) S18-S25
14. Dysport (abobotulinumtoxinA) [package insert] (2009), Medicis Aesthetics, Scottsdale, AZ
15. Pierard G.E., and Lapiere C.M. The microanatomical basis of facial frown lines. Arch Dermatol 125 (1989) 1090-1092
16. Brandt F., Swanson N., Baumann L., and Huber B. Randomized, placebo-controlled study of a new botulinum toxin type A for treatment of glabellar lines: efficacy and safety. Dermatol Surg (2009 Jul 28) [Epub ahead of print].
17. Rubin M.G., Dover J.S., Glogau R.G., Goldberg D.J., Goldman M.P., and Schlessinger J. The efficacy and safety of a new U.S. botulinum toxin type A in the retreatment of glabellar lines following open-label treatment. J Drugs Dermatol 8 (2009) 439-444
18. Kane M., Brandt F., Rohrich R.J., et al. Evaluation of variable-dose treatment with a new US botulinum toxin type A (Dysport) for correction of moderate to severe glabellar lines: results from a phase 3, randomized, double-blind, placebo-controlled study. Plast Reconstr Surg (2009 Jul 28) [Epub ahead of print].
19. Moy R., Maas C., Monheit G., Huber B., and Reloxin Investigational Group. Long-term safety and efficacy of a new botulinum toxin type A in treating glabellar lines. Arch Facial Plast Surg 11 (2009) 77-83
20. Monheit G.D., Cohen J.L., and Reloxin Investigational Group. Long-term safety of repeat administrations of a new formulation of botulinum toxin type A in the treatment of glabellar lines: interim analysis from an open-label extension study. J Am Acad Dermatol 61 (2009) 421-425
21. Fitzpatrick T.B. The validity and practicality of sun-reactive skin types. Arch Dermatol 124 (1988) 869-871