Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene product

FEBS Letters

Volumn 584, Issue 1, 2010, Pages 39-43

  Wang, Lu ^a   Kobayashi, Toshiyuki ^a   Piao, Xianghua ^a   Shiono, Masatoshi ^a   Takagi, Yumiko ^a   Mineki, Reiko ^a   Taka, Hikari ^a   Zhang, Danqing ^a   Abe, Masaaki ^a   Sun, Guodong ^a   Hagiwara, Yoshiaki ^b   Okimoto, Kazuo ^c   Matsumoto, Izumi ^c   Kouchi, Mami ^c   Hino, Okio ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Immuno Biological Laboratories Co Ltd   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

5 AMP activated protein kinase; Birt Hogg Dub syndrome; FLCN interacting protein; Folliculin; Phosphorylation

Indexed keywords

ANTIBODY; ESTRONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; SERINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BIRT HOGG DUBE SYNDROME; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; ANTIBODIES, PHOSPHO-SPECIFIC; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; COS CELLS; PHOSPHORYLATION; PROTEIN KINASES; PROTEINS; RATS; SERINE;

EID: 71549132196     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.11.033     Document Type: Article

References (11)

1. Birt A.R., Hogg G.R., and Dubé W.J. Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch. Dermatol. 113 (1977) 1674-1677
2. Nickerson M.L., Warren M.B., Toro J.R., Matrosova V., Glenn G., Turner M.L., Duray P., Merino M., Choyke P., Pavlovich C.P., Sharma N., Walther M., Munroe D., Hill R., Maher E., Greenberg C., Lerman M.I., Linehan W.M., Zbar B., and Schmidt L.S. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Cancer Cell 2 (2002) 157-164
3. Okimoto K., Sakurai J., Kobayashi T., Mitani H., Hirayama Y., Nickerson M.L., Warren M.B., Zbar B., Schmidt L.S., and Hino O. A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Proc. Natl. Acad. Sci. USA 101 (2004) 2023-2027
4. Baba M., Hong S.B., Sharma N., Warren M.B., Nickerson M.L., Iwamatsu A., Esposito D., Gillette W.K., Hopkins III R.F., Hartley J.L., Furihata M., Oishi S., Zhen W., Burke Jr. T.R., Linehan W.M., Schmidt L.S., and Zbar B. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. USA 103 (2006) 15552-15557
5. Hasumi H., Baba M., Hong S.B., Hasumi Y., Huang Y., Yao M., Valera V.A., Linehan W.M., and Schmidt L.S. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene 415 (2008) 60-67
6. Takagi Y., Kobayashi T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., and Hino O. Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. Oncogene 27 (2008) 5339-5347
7. Inoki K., Corradetti M.N., and Guan K.L. Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet. 37 (2005) 19-24
8. van Slegtenhorst M., Khabibullin D., Hartman T.R., Nicolas E., Kruger W.D., and Henske E.P. The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe. J. Biol. Chem. 282 (2007) 24583-24590
9. Mineki R., Taka H., Fujimura T., Kikkawa M., Shindo N., and Murayama K. In situ alkylation with acrylamide for identification of cysteinyl residues in proteins during one- and two-dimensional sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Proteomics 2 (2002) 1672-1681
10. Mukhopadhyay N.K., Price D.J., Kyriakis J.M., Pelech S., Sanghera J., and Avruch J. An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase. J. Biol. Chem. 267 (1992) 3325-3335
11. Piao X., Kobayashi T., Wang L., Shiono M., Takagi Y., Sun G., Abe M., Hagiwara Y., Zhang D., Okimoto K., Kouchi M., Matsumoto I., and Hino O. Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. Biochem. Biophys. Res. Commun. 389 (2009) 16-21