Monitoring of cellular immune responses with an optical biosensor: a new tool to assess nanoparticle toxicity

Procedia Chemistry

Volumn 1, Issue 1, 2009, Pages 738-741

  Pasche, S ^a   Giazzon, M ^a   Wenger, B ^a   Franc, G ^a   Ischer, R ^a   Oostingh, G J ^b   Voirin, G ^a  

^a CSEM   (Switzerland)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Cell culture monitoring; Cytokine detection; Immunoassay; Nanotoxicity; Optical biosensors

Indexed keywords

CELLULAR EVENTS; CHEMOKINES; CONTINUOUS MONITORING; CYTOKINE DETECTION; CYTOKINES; DETECTION DEVICE; FLUIDIC CHANNELS; FOREIGN AGENTS; IMMUNE RESPONSE; IN-CELL; IN-VITRO; INFLAMMATORY CYTOKINES; INFLAMMATORY PROCESS; INTEGRATED DETECTION; INTERLEUKIN-8; LABEL FREE; NANOPARTICLE TOXICITY; NANOTOXICITY; NEW TOOLS; OPTICAL BIO-SENSORS; OPTICAL DETECTION; PARALLEL DETECTION;

ANTIGENS; BIOASSAY; BIOSENSORS; CELL CULTURE; IMMUNOLOGY; NANOPARTICLES; SIGNAL TRANSDUCTION; TOXICITY;

CONTINUOUS CELL CULTURE;

EID: 71549130724     PISSN: 18766196     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1016/j.proche.2009.07.184     Document Type: Conference Paper

References (4)

1. Kroll A, Pillukat MH, Hahn D, Schekenburger J. Current in vitro methods in nanoparticle risk assessment: Limitations and challenges. European Journal of Pharamceutics and Biopharmaceutics 2008;xxx:pp-p.
2. Pfaller T., Puntes V., Casals E., Duschl A., and Oostingh G.J. In vitro investigation of immunomodulatory effects caused by engineered inorganic nanoparticles - the impact of experimental design and cell choice. Nanotoxicology 3 (2009) 46-59
3. Cottier K., Wiki M., Voirin G., Gao H., and Kunz R.E. Label-free highly sensitive detection of (small) molecules by wavelength interrogation of integrated optical chips. Sensors and Actuators B 91 (2003) 241-251
4. Caelen I., Gao H., and Sigrist H. Protein density gradients on surfaces. Langmuir 18 (2002) 2463-2467