Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation

Cancer Research

Volumn 69, Issue 23, 2009, Pages 9112-9117

  Anderson, Philip D ^a   Nelson, Vicki R ^a   Tesar, Paul J ^a,b   Nadeau, Joseph H ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SUSCEPTIBILITY; CHROMOSOME; CHROMOSOME 18; CHROMOSOME SUBSTITUTION STRAIN; CONGENIC STRAIN; CONTROLLED STUDY; EMBRYONIC STEM CELL; FAMILY; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GERM CELL TUMOR; HEREDITY; INBRED STRAIN; LINKAGE ANALYSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TESTIS TERATOMA; TUMOR LOCALIZATION;

ANIMALS; CHROMOSOMES, MAMMALIAN; EMBRYONIC STEM CELLS; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE; MICE, CONGENIC; QUANTITATIVE TRAIT LOCI; TERATOCARCINOMA; TESTICULAR NEOPLASMS;

EID: 71549128688     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3342     Document Type: Article

References (50)

1. Krain L. Testicular cancer in California from 1942 to 1969: the California Tumor Registry experience. Oncology 1973;27:45-51.
2. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106-130
3. Talerman A. Germ cell tumours. Ann Pathol 1985;5:145-157
4. Forman D, Oliver R, Brett A, et al. Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis. Br J Cancer 1992;65:255-262
5. Lindelöf B, Eklund G. Analysis of hereditary component of cancer by use of a familial index by site. Lancet 2001;358:1696-1698 (Pubitemid 33124331)
6. Czene K, Lichtenstein P, Hemminki K. Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family Cancer Database. Int J Cancer 2002;99:260-266 (Pubitemid 34309484)
7. Hemminki K, Li X. Familial risk in testicular cancer as a clue to heritable and environmental etiology. Br J Cancer 2004;90:1765-1770 (Pubitemid 38725649)
8. Swerdlow AJ, De Stavola B, Swanwick M, Mangtani P, Maconochie N. Risk factors for testicular cancer: a case-control study in twins. Br J Cancer 1999;80:1098-1102 (Pubitemid 29233936)
9. Nathanson KL, Kanetsky PA, Hawes R, et al. The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am J Hum Genet 2005;77:1034-1043 (Pubitemid 41698523)
10. Kanetsky PA, Mitra N, Vardhanabhuti S, et al. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet 2009;41:811-815
11. Rapley EA, Turnbull C, Al Olama AA, et al. A genome-wide association study of testicular germ cell tumor. Nat Genet 2009;41:807-810
12. Stevens LC. Origin of testicular teratomas from primordial germ cells in mice. J Natl Cancer Inst 1967;38:549-552
13. Heaney JD, Lam MY, Michelson MV, Nadeau JH. Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice. Cancer Res 2008;68:5193-5197
14. Stevens LC, Little CC. Spontaneous testicular teratomas in an inbred strain of mice. Proc Natl Acad Sci U S A 1954;40:1080-1087
15. Stevens LC, Hummel K. A description of spontaneous congenital testicular teratomas in strain 129 mice. J Natl Cancer Inst 1957;18:719-747
16. van Echten J, Timmer A, van der Veen AY, Molenaar WM, de Jonga B. Infantile and adult testicular germ cell tumors: a different pathogenesis? Cancer Genet Cytogenet 2002;135:57-62.
17. Collin GB, Asada Y, Varnum DS, Nadeau JH. DNA pooling as a quick method for fidning candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors. Mamm Genome 1996;7:68-70. (Pubitemid 126439714)
18. Muller AJ, Teresky AK, Levine AJ. A male germ cell tumor-susceptibility- determining locus, pgct1, identified on murine chromosome 13. Proc Natl Acad Sci U S A 2000;97:8421-8426
19. Nadeau JH, Singer JB, Matin A, Lander ES. Analysing complex genetic traits with chromosome substitution strains. Nat Genet 2000;24:221-225 (Pubitemid 30132188)
20. Belknap JK. Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping. Mamm Genome 2003;14:723-732
21. Youngren KK, Nadeau JH, Matin A. Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications. Hum Mol Genet 2003;12:389-398 (Pubitemid 36285131)
22. Buchner DA, Burrage LC, Hill AE, et al. Resistance to diet-induced obesity in mice with a single substituted chromosome. Physiol Genomics 2008;35:116-122
23. Shao H, Burrage LC, Sinasac DS, et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci U S A 2008;105:19910-19914
24. Millward CA, Burrage LC, Shao H, et al. Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17. Mamm Genome 2009;20:71-82.
25. Matin A, Collin GB, Asada Y, Varnum D, Nadeau JH. Susceptibility to testicular germ-cell tumours in a 129. MOLF-Chr 19 chromosome substitution strain. Nat Genet 1999;23:237-240
26. Moriwaki K. Wild mouse from a geneticist's viewpoint. In: Moriwaki K, Shiroishi T, Yonekawa H, editors. Genetics in wild mice; its application to biomedical research. Tokyo: Japan Scientific Press and Karger; 1994, p. xiii-iv.
27. Silver L. Mouse genetics: concepts and applications. New York: Oxford University Press; 1995, p. 376.
28. Bonhomme F, Guénet J-L. The laboratory mouse and its wild relatives. In: Lyon S, Rastan S, Brown S, editors. Genetic variants and strains of the laboratory mouse. Oxford: Oxford University Press; 1996, p. 1577-1596
29. Bevova MR, Aulchenko YS, Aksu S, Renne U, Brockmann GA. Chromosome-wise dissection of the genome of the extremely big mouse line DU6i. Genetics 2006;172:401-410 (Pubitemid 43345501)
30. Stevens LC. The biology of teratomas. Adv Morphog 1967;6:1-31.
31. Lam M-Y, Youngren KK, Nadeau JH. Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice. Genetics 2004;166:925-933
32. Lam M-Y, Heaney JD, Youngren KK, Kawasoe JH, Nadeau JH. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet 2007;16:2233-2240
33. Brook FA, Gardner RL. The origin and efficient derivation of embryonic stem cells in the mouse. Proc Natl Acad Sci U S A 1997;94:5709-5712 (Pubitemid 27241834)
34. Summers MC, Bhatnagar PR, Lawitts JA, Biggers JD. Fertilization in vitro of mouse ova from inbred and outbred strains: complete preimplantation embryo development in glucose-supplemented KSOM. Biol Reprod 1995;53:431-437
35. Nichols J, Ying QL. Derivation and propagation of embryonic stem cells in serum- and feeder-free culture. Methods Mol Biol 2006;329:91-98
36. Liu J, Schoonjans L, Tielens S, et al. Culturing in vitro produced blastocysts in sequential media promotes ES cell derivation. Mol Reprod Dev 2006;73:1017-1021 (Pubitemid 43993540)
37. Robertson EJ. Teratocarcinomas and embryonic stem cells: a practical approach. Washington (DC): Oxford-IRL; 1987, p. 71-112.
38. Rapley EA, Crockford GP, Teare D, et al. Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat Genet 2000;24:197-200. (Pubitemid 30094725)
39. Smith AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol 2001;17:435-462 (Pubitemid 33096183)
40. Crockford GP, Linger R, Hockley S, et al. Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Hum Mol Genet 2006;15:443-451 (Pubitemid 43159896)
41. Patriotis C, Makris A, Bear SE, Tsichlis PN. Tumor progression locus-2 (TPL-2) encodes a protein-kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci U S A 1993;90:2251-2255 (Pubitemid 23078604)
42. Patriotis C, Makris A, Chernoff J, Tsichlis PN. Tpl-2 acts in concert with Ras and Raf-1 to activate mitogen-activated protein kinase. Proc Natl Acad Sci U S A 1994;91:9755-9759 (Pubitemid 24311886)
43. Leeksma OC, Van Achterberg TA, Tsumura Y, et al. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. Eur J Biochem 2002;269:2546-2556 (Pubitemid 34539283)
44. Tokuzawa Y, Kaiho E, Maruyama M, et al. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 2003;23:2699-2708 (Pubitemid 36403071)
45. Gidekel S, Pizov G, Bergman Y, Pikarsky E. Oct-3/4 is a dose-dependent oncogenic fate determinant. Cancer Cell 2003;4:361-370 (Pubitemid 37491097)
46. Heaney JD, Michelson MV, Youngren KK, Lam MY, Nadeau JH. Deletion of eIF2β suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice. Hum Mol Genet 2009;18:1395-1404
47. Stevens LC. A new inbred subline of mice (129-TerSv) with a high incidence of spontaneous congenital testicular teratomas. J Natl Cancer Inst 1973;50:235-242
48. Noguchi T, Noguchi M. A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-Ter mice. J Natl Cancer Inst 1985;75:385-392 (Pubitemid 15229346)
49. Brook FA, Evans EP, Lord CJ, et al. The derivation of highly germline-competent embryonic stem cells containing NOD-derived genome. Diabetes 2003;52:205-208
50. Hanna J, Markoulaki S, Mitalipova M, et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 2009;4:513-524