A novel hepatitis B virus mutant coexisting with wild type virus in a carrier with negative HBsAg yet positive HBeAg and anti-HBs

Journal of Clinical Virology

Volumn 46, Issue 4, 2009, Pages 363-366

  Zhou, Yi Hua ^a   Zhou, Jianxin ^a   Li, Lei ^a   Bi, Yongchun ^a   Liu, Yong ^a   Pan, Jinshun ^a   Wu, Chao ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Anti HBs; Escape mutant; HBeAg; HBsAg; Hepatitis B virus

Indexed keywords

HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; ARTICLE; CASE REPORT; ENZYME IMMUNOASSAY; ESCAPE MUTANT; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROLOGY; VIRUS CARRIER; VIRUS HEPATITIS; VIRUS MUTANT;

AMINO ACID SEQUENCE; BASE SEQUENCE; CARRIER STATE; FOLLOW-UP STUDIES; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA;

EID: 71549128048     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcv.2009.09.012     Document Type: Article

References (13)

1. Zuckerman A.J. Effect of hepatitis B virus mutants on efficacy of vaccination. Lancet 355 (2000) 1382-1384
2. Cooreman M.P., Leroux-Roels G., and Paulij W.P. Vaccine- and hepatitis B immune globulin-induced escape mutations of hepatitis B virus surface antigen. J Biomed Sci 8 (2001) 237-247
3. Carman W.F., Zanetti A.R., Karayiannis P., Waters J., Manzillo G., Tanzi E., et al. Vaccine-induced escape mutant of hepatitis B virus. Lancet 336 (1990) 325-329
4. Oon C.J., Lim G.K., Ye Z., Goh K.T., Tan K.L., Yo S.L., et al. Molecular epidemiology of hepatitis B virus vaccine variants in Singapore. Vaccine 13 (1995) 699-702
5. Mu S.C., Lin Y.M., Jow G.M., and Chen B.F. Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan. J Hepatol 50 (2009) 264-272
6. de Man R.A., Bartholomeusz A.I., Niesters H.G., Zondervan P.E., and Locarnini S.A. The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss. J Hepatol 29 (1998) 669-675
7. Rodriguez-Frias F., Buti M., Jardi R., Vargas V., Quer J., Cotrina M., et al. Genetic alterations in the S gene of hepatitis B virus in patients with acute hepatitis B, chronic hepatitis B and hepatitis B liver cirrhosis before and after liver transplantation. Liver 19 (1999) 177-182
8. Hsu C.W., Yeh C.T., Chang M.L., and Liaw Y.F. Identification of a hepatitis B virus S gene mutant in lamivudine-treated patients experiencing HBsAg seroclearance. Gastroenterology 132 (2007) 543-550
9. Tacke F., Amini-Bavil-Olyaee S., Heim A., Luedde T., Manns M.P., and Trautwein C. Acute hepatitis B virus infection by genotype F despite successful vaccination in an immune-competent German patient. J Clin Virol 38 (2007) 353-357
10. Weber B., Melchior W., Gehrke R., Doerr H.W., Berger A., and Rabenau H. Hepatitis B virus markers in anti-HBc only positive individuals. J Med Virol 64 (2001) 312-319
11. Raimondo G., Pollicino T., Cacciola I., and Squadrito G. Occult hepatitis B virus infection. J Hepatol 46 (2007) 160-170
12. Levicnik-Stezinar S., Rahne-Potokar U., Candotti D., Lelie N., and Allain J.P. Anti-HBs positive occult hepatitis B virus carrier blood infectious in two transfusion recipients. J Hepatol 48 (2008) 1022-1025
13. Candotti D., Grabarczyk P., Ghiazza P., Roig R., Casamitjana N., Iudicone P., et al. Characterization of occult hepatitis B virus from blood donors carrying genotype A2 or genotype D strains. J Hepatol 49 (2008) 537-547