Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol

Pharmaceutical Research

Volumn 15, Issue 3, 1998, Pages 442-448

  Cox, Eugene H ^a   Knibbe, Catherijne A J ^b   Koster, Victorine S ^b   Langemeijer, Mariska W E ^a   Tukker, Erica E ^a   Lange, Rogier ^b   Kuks, Paul F M ^b   Langemeijer, Han J M ^b   Lie A Huen, Loraine ^b   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

EEG; Fat emulsion; Pharmacodynamics; Pharmacokinetics; Propofol; Rats

Indexed keywords

INTRALIPID; LIPID EMULSION; LIPOFUNDIN; PROPOFOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DATA ANALYSIS; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; ELECTROENCEPHALOGRAM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

ANESTHETICS, INTRAVENOUS; ANIMALS; DRUG COMBINATIONS; ELECTROENCEPHALOGRAPHY; FAT EMULSIONS, INTRAVENOUS; INFUSIONS, INTRAVENOUS; MALE; MODELS, STATISTICAL; PHOSPHOLIPIDS; PROPOFOL; RATS; RATS, WISTAR; SORBITOL; STATISTICS, NONPARAMETRIC;

EID: 7144263713     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011980432646     Document Type: Article

References (30)

1. H. M. Bryson, B. R. Fulton, and D. Faulds. Propofol: an update on its use in anesthesia and conscious sedation. Drugs 50:513-559 (1995).
2. M. Lindholm. Critically ill patients and fat emulsions. Minerva. Anestesiol. 58:875-879 (1992).
3. V. S. Koster, J. G. Maring, C. A. J. Knibbe, R. Lange, P. F. M. Kuks, J. J. M. Langemeijer, L. P. H. J. Aarts, H. Talsma, and L. Lie-A-Huen. Propofol-6%: preparation and stability of a new formulation of propofol. J. Pharm. Sci. in press (1998).
4. J. Bable, A. Doenicke, and V. Monch. New formulation of propofol in an LCT/MCT emulsion: approach to reduce pain on injection. EHP 1:15-22 (1995).
5. A. Tibell, A. Lindholm, J. Sawe, G. Chen, and B. Norrlind. Cyclosporin A in fat emulsion carriers: experimental studies on pharmacokinetics and tissue distribution. Pharmacol. Toxicol. 76:115-121 (1995).
6. A. Sparreboom, O. van Tellingen, W. J. Nooijen, and J. H. Beijnen. Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL. Cancer Res. 56:2112-2115 (1996).
7. L. K. Webster, E. J. Cosson, K. H. Stokes, and M. J. Millward. Effect of the paclitaxel vehicle, Cremophor EL, on the pharmacokinetics of doxorubicin and doxorubicinol in mice. Br. J. Cancer 73:522-524 (1996).
8. D. J. Straathof, O. Driessen, J. W. Meijer, H. Van Rees, P. Vermeij. and T. A. Vermeij. Influence of Intralipid infusion on the elimination of phenytoin. Arch. Int. Pharmacodyn. Ther. 267:180-186 (1984).
9. J. W. Mandema and M. Danhof. Pharamcokinetic-pharmacodynamic modelling of the CNS effects of heptabarbital using aperiodic EEG analysis. J. Pharmacokin. Biopharm. 18:459-481 (1990).
10. E. H. Cox, A. G. N. Van Hemert, E. Tukker, and M. Danhof. Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil. J. Pharmacol. Toxicol. Methods, 38:99-108 (1997).
11. C. A. J. Knibbe, V. S. Koster, V. H. M. Deneer, R. Stuurman, P. F. M. Kuks, and R. Lange. Determination of propofol in low volume samples by high-performance liquid chromatography with fluorescence detection. J. Chrom., in press (1998).
12. D. Verotta and L. B. Sheiner. Simultaneous modelling of pharmacokinetics and pharmacodynamics II. An improved algorithm. Comp. Applicat. Biosci. 3:345-349 (1987).
13. W. F. Ebling, M. Danhof, and D. R. Stanski. Pharmacodynamic characterization of the electroencephalographic effects of thiopental in J. Pharmacokin. Biopharm. 19:123-143 (1991).
14. B. Fulton and E. M. Sorkin. Propofol. An overview of its pharmacology and a review of its clinical efficacy in intensive care sedation. Drugs 50:636-657 (1995).
15. H. K. Adam, J. B. Glen, and P. A. Hoyle. Pharmacokinetics in laboratory animals of ICI 35 868. a new i.v. anaesthetic agent. Br. J. Anaesth. 52:743-746 (1980).
16. S. Dutta, Y. Matsumoto, and W. F. Ebling. Role of intralipid in the pharmacokinetics and pharmacodynamics of propofol in rats. Pharm. Res. 12:S401 (1995).
17. S. Dutta, Y. Matsumoto, N. U. Gothgen, and W. F. Ebling. Concentration-EEG effect relationship of propofol in rats. J. Pharm. Sci. 86:37-43 (1997).
18. I. D. Cockshott, E. J. Douglas, G. F. Plummer, and P. J. Simons. The pharmacokinetics of propofol in laboratory animals. Xenobiotica 22:369-375 (1992).
19. K. Leslie, D. I. Sessler, A. R. Bjorksten, and A. Moayeri. Mild hypothermia alters propofol pharmacokinetics and increases the duratio of action of atracurium. Anesth. Analg. 80:1007-1014 (1995).
20. J. Dingemanse, M. Danhof, and D. D. Breimer. Pharmacokinetic-pharmacodynamic modelling of CNS drug effects. An overview. Pharmacol. Ther. 38:1-52 (1988).
21. J. W. Mandema, E. Tukker, and M. Danhof. Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration. Br. J. Pharmacol. 102:663-668 (1991).
22. J. W. Mandema, C. D. Heijligers-Feijen, E. Tukker, A. G. De Boer, and M. Danhof. Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures. J. Pharmacol. Exp. Ther. 261:88-95 (1992).
23. K. Tomoda, K. Shingu, M. Osawa, M. Murakawa, and K. Mori. Comparison of CNS effects of propofol and thiopentone in cats. Br. J. Anaesth. 71:383-387 (1993).
24. K. Hartikainen, M. Rorarius, K. Makela, A. Yli-Hankala, and V. Jantti. Propofol and isoflurane induced EEG burst suppression patterns in rabbits. Acta Anaesthesiol. Scand. 39:814-818 (1995).
25. R. V. Reddy, S. S. Moorthy, T. Mattice, S. F. Dierdorf, and R. D. Deitch, Jr. An electroencephalographic comparison of effects of propofol and methohexital. Electroencephalogr. Clin. Neurophysiol. 83:162-168 (1992).
26. F. C. Forrest, M. A. Tooley, P. R. Saunders, and C. Prys-Roberts. Propofol infusion and the suppression of consciousness: the EEG and dose Br. J. Anaesth. 72:35-41 (1994).
27. J. W. Mandema, P. Veng-Pedersen, and M. Danhof. Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of poly-exponential conductance functions. J. Pharmacokin. Biopharm. 19:617-634 (1991).
28. P. Altmayer, U. Buch, and H. P. Buch. Propofol binding to human blood proteins. Arzneimittelforschung 45:1053-1056 (1995).
29. P. M. Klockowski and G. Levy. Kinetics of drug action in disease states. XXIII: Effect of acute hypovolemia on the pharmacodynamics of phenobarbital in. rats J. Pharm. Sci. 77:365-366 (1988).
30. E. Vandermeersch, J. Van Hemelrijck, G. Byttebier, and H. Van Aken. Pharmacokinetics of propofol during continuous infusion for pediatric anesthesia. Acta Anaesthesiol. Belg. 40:161-165 (1989).