CD44 variant expression in inflammatory colonic mucosa is not disease specific but associated with increased crypt cell proliferation

Histopathology

Volumn 32, Issue 4, 1998, Pages 317-321

  Fromont Hankard, G ^a   Cezard, J P ^a   Aigrain, Y ^a   Navarro, J ^a   Peuchmaur, M ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

CD44; Crohn's disease; Crypt cell proliferation; Ulcerative colitis

Indexed keywords

HERMES ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL TRIAL; COLON MUCOSA; CROHN DISEASE; CRYPT CELL; HUMAN; INFLAMMATORY INFILTRATE; PRIORITY JOURNAL;

ANTIGENS, CD44; ANTIGENS, NUCLEAR; CELL DIVISION; CHILD; COLITIS, ULCERATIVE; CROHN DISEASE; DNA-BINDING PROTEINS; GLYCOPROTEINS; HUMANS; IMMUNITY, MUCOSAL; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; NUCLEAR PROTEINS;

EID: 7144259067     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.1998.00404.x     Document Type: Article

References (13)

1. Wells AD, McMillan I, Price AB, Ritchie JK, Nicholls RJ. Natural history of undeterminate colitis. Br. J. Surg. 1991; 78; 179-181.
2. Rosenberg WMC, Prince C, Kaklamanis L et al. Increased expression of CD44 V6 and CD44 V3 in ulcerative colitis but not colonic Crohn's disease, Lancet 1995; 345; 1205-1209.
3. Papadoginnakis N, Gad A, Chenard MP, Bellocq JP, Duclos B. Expression of CD44 variants in differential diagnosis of ulcerative colitis and Crohn's disease, Lancet 1996; 347; 1413-1414.
4. Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Günthert U. Expression and modulation of CD44 variant isoforms in humans. J. Cell Biol. 1994; 124; 71-82.
5. Fox SB, Gatter KC, Jackson DG et al. CD44 and cancer screening. Lancet 1993; 342; 548-549.
6. Key G, Becker M, Baron B et al. Preparation and (MIB 1-3) generated against recombinant part of the Ki67 antigen. Anal. Cell Pathol. 1992; 4; 159-161.
7. Przemioslo R, Wright NA, Elia G, Ciclitira PJ. Analysis of crypt cell proliferation in coeliac disease using MIB 1 antibody shows an increase in growth fraction. Gut 1995; 56; 22-27.
8. Stamenkovic I, Aruffo A, Amiot M, Seed B. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J. 1991; 10; 343-348.
9. Screaton GR, Bell MV, Jackson DG, Cornelis FB, Gerth U, Bell JI, Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc. Natl. Acad. Sci. USA 1992; 89; 2160-2164.
10. Wielenga VJM, Heider KH, Offerhaus GJA et al. Expression of CD44 variant proteins in human colorectal cancer is related to tumour progression. Cancer Res. 1993; 53; 4754-4756.
11. Mulder JWR, Wielenga VJM, Polak MM et al. Expression of mutant p53 protein and CD44 variant protein in colorectal tumourigenesis. Gut 1995; 36; 76-80.
12. Gorham H, Sugino T, Woodman AC, Tarin D. Cellular distribution of CD44 gene transcripts in colorectal carcinomas and in normal colonic mucosa. J. Clin. Pathol. 1996; 49; 482-488.
13. Ryder SD, Parker N, Ecclestone D, Haqqani MT, Rhodes JM. Peanut lectin stimulates proliferation in colonic explants from patients with inflammatory bowel disease and colonic polyps. Gastroenterology 1994; 106; 117-124.