메뉴 건너뛰기




Volumn 21, Issue 2, 1998, Pages 95-103

New drugs in colorectal cancer: A review of antitumor activity and cross-resistance patterns of topoisomerase I inhibitors, thymidylate synthetase inhibitors, and oxaliplatin

Author keywords

Colon cancer; Irinotecan; Oxaliplatin; Tomudex; Topoisomerase I Inhibitors

Indexed keywords

9 AMINOCAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; NOLATREXED; OXALIPLATIN; PEMETREXED; RALTITREXED; THYMIDYLATE SYNTHASE INHIBITOR; TOPOTECAN;

EID: 7144257872     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026804     Document Type: Review
Times cited : (15)

References (76)
  • 2
    • 0022829861 scopus 로고
    • Epidemiologic patterns of colorectal cancer
    • DeVita VT Jr, Hellman S, Rosenberg SA (eds): Philadelphia, Lippincott
    • Ziegler RG, Devesa SS, Fraumeni JF Jr: Epidemiologic patterns of colorectal cancer; in DeVita VT Jr, Hellman S, Rosenberg SA (eds): Important Advances in Oncology. Philadelphia, Lippincott, 1986, pp 209-232.
    • (1986) Important Advances in Oncology , pp. 209-232
    • Ziegler, R.G.1    Devesa, S.S.2    Fraumeni Jr., J.F.3
  • 5
    • 0029644482 scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer
    • International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators: Efficacy of adjuvant fluorouracil and folinic acid in colon cancer Lancet 1995;345:939-944.
    • (1995) Lancet , vol.345 , pp. 939-944
  • 6
    • 0029067247 scopus 로고
    • Chemotherapy for colorectal carcinoma: One small step forward, one step backward
    • Kemeny N: Chemotherapy for colorectal carcinoma: One small step forward, one step backward. J Clin Oncol 1995;13:1287-1290
    • (1995) J Clin Oncol , vol.13 , pp. 1287-1290
    • Kemeny, N.1
  • 8
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
    • Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. J Clin Oncol 1992;10:896-903.
    • (1992) J Clin Oncol , vol.10 , pp. 896-903
  • 11
    • 0028956096 scopus 로고
    • Phase III randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer
    • Corfu-A Study Group: Phase III randomized study of two fluorouracil combinations with either interferon alfa-2a or leucovorin for advanced colorectal cancer. J Clin Oncol 1995;13:921-928.
    • (1995) J Clin Oncol , vol.13 , pp. 921-928
  • 13
    • 0029055178 scopus 로고
    • Treatment of advanced colorectal cancer with 5-fluorouracil and interferon alpha: An overview of clinical trials
    • Raderer M, Scheithauer W: Treatment of advanced colorectal cancer with 5-fluorouracil and interferon alpha: An overview of clinical trials. Eur J Cancer 1995;31:1002-1008
    • (1995) Eur J Cancer , vol.31 , pp. 1002-1008
    • Raderer, M.1    Scheithauer, W.2
  • 14
    • 0018926163 scopus 로고
    • Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells
    • Evans RM, Laskin JD, Hakala MT: Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells Cancer Res 1980; 40:4113-4122.
    • (1980) Cancer Res , vol.40 , pp. 4113-4122
    • Evans, R.M.1    Laskin, J.D.2    Hakala, M.T.3
  • 15
    • 0022651846 scopus 로고
    • Schedule-dependent cytotoxicity of 5-fluorouracil in mice
    • Santelli G, Valeriote F: Schedule-dependent cytotoxicity of 5-fluorouracil in mice. J Natl Cancer Inst 1986;76:159-164.
    • (1986) J Natl Cancer Inst , vol.76 , pp. 159-164
    • Santelli, G.1    Valeriote, F.2
  • 16
    • 0015962412 scopus 로고
    • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
    • Santi DV, McHenry CS, Sommer H Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 1974;13 471-480.
    • (1974) Biochemistry , vol.13 , pp. 471-480
    • Santi, D.V.1    McHenry, C.S.2    Sommer, H.3
  • 18
    • 0025997350 scopus 로고
    • ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
    • Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR: ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study. Cancer Res 1991;51:5579-5586.
    • (1991) Cancer Res , vol.51 , pp. 5579-5586
    • Jackman, A.L.1    Taylor, G.A.2    Gibson, W.3    Kimbell, R.4    Brown, M.5    Calvert, A.H.6    Judson, I.R.7    Hughes, L.R.8
  • 20
    • 0002997779 scopus 로고
    • Influence of intracellular polyglutamation on the cytotoxicity of the thymidylate synthase inhibitor 1843U89
    • abstract 1630
    • Ferone R, Hanlon MH, Waters KA, Dev IK: Influence of intracellular polyglutamation on the cytotoxicity of the thymidylate synthase inhibitor 1843U89. Proc Am Assoc Cancer Res 1993;34:274 (abstract 1630)
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 274
    • Ferone, R.1    Hanlon, M.H.2    Waters, K.A.3    Dev, I.K.4
  • 23
    • 0026637845 scopus 로고
    • Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
    • Aschele C, Sobrero A, Faderan MA: Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 1992;52:1855-1864.
    • (1992) Cancer Res , vol.52 , pp. 1855-1864
    • Aschele, C.1    Sobrero, A.2    Faderan, M.A.3
  • 24
    • 0342433993 scopus 로고
    • Development and characterisation of human gastric, colon and breast carcinoma cell lines resistant to 5-FU using various, clinically relevant application schedules
    • abstract 1889
    • Harstrick A, Gonzales A, Hoffmann A, Schleucher N, Vanhoefer U, Rustum Y, Seeber S, Wilke H: Development and characterisation of human gastric, colon and breast carcinoma cell lines resistant to 5-FU using various, clinically relevant application schedules. Proc Am Assoc Cancer Res 1995;36:317 (abstract 1889).
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 317
    • Harstrick, A.1    Gonzales, A.2    Hoffmann, A.3    Schleucher, N.4    Vanhoefer, U.5    Rustum, Y.6    Seeber, S.7    Wilke, H.8
  • 25
    • 0029031286 scopus 로고
    • Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (tomudex) in one mouse and three human cell lines
    • Jackman AL, Kelland LR, Kimbell R, Brown M, Gibson W, Aherne GW, Hardcastle A, Boyle FT: Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (tomudex) in one mouse and three human cell lines. Br J Cancer 1995;71:914-924.
    • (1995) Br J Cancer , vol.71 , pp. 914-924
    • Jackman, A.L.1    Kelland, L.R.2    Kimbell, R.3    Brown, M.4    Gibson, W.5    Aherne, G.W.6    Hardcastle, A.7    Boyle, F.T.8
  • 26
    • 0028787690 scopus 로고
    • Fluorouracil: Active in ZD1694 (tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels
    • Johnston PG, Behan KA, Allegra CJ, Drake JC: Fluorouracil: Active in ZD1694 (tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels. J Natl Cancer Inst 1995;87 1558-1559.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1558-1559
    • Johnston, P.G.1    Behan, K.A.2    Allegra, C.J.3    Drake, J.C.4
  • 27
    • 0029120895 scopus 로고
    • Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2- thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcimoma cell line
    • Lu K, Yin MB, McGuire JJ, Bonmassar E, Rustum YM: Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2- thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcimoma cell line. Biochem Pharmacol 1995;50:391-398.
    • (1995) Biochem Pharmacol , vol.50 , pp. 391-398
    • Lu, K.1    Yin, M.B.2    McGuire, J.J.3    Bonmassar, E.4    Rustum, Y.M.5
  • 28
    • 0029960812 scopus 로고    scopus 로고
    • Eukaryotic DNA topoisomerase I: Genome gatekeeper and its intruders, camptothecins
    • Pommier Y Eukaryotic DNA topoisomerase I: Genome gatekeeper and its intruders, camptothecins. Semin Oncol 1996;23(suppl 3) 3-10
    • (1996) Semin Oncol , vol.23 , Issue.3 SUPPL. , pp. 3-10
    • Pommier, Y.1
  • 29
    • 0028174984 scopus 로고
    • DNA topoisomerases: Essential enzymes and lethal targets
    • Chen AY, Liu LF. DNA topoisomerases: Essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol 1994;34:191-218
    • (1994) Annu Rev Pharmacol Toxicol , vol.34 , pp. 191-218
    • Chen, A.Y.1    Liu, L.F.2
  • 30
    • 0024316466 scopus 로고
    • DNA topoisomerase poisons as antitumor drugs
    • Liu LF: DNA topoisomerase poisons as antitumor drugs Annu Rev Biochem 1989;58:351-375.
    • (1989) Annu Rev Biochem , vol.58 , pp. 351-375
    • Liu, L.F.1
  • 31
    • 0025812689 scopus 로고
    • Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA
    • Ryan AJ, Squires S, Strutt HL, Johnson RT: Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA. Nucleic Acids Res 1991;19:3295-3300.
    • (1991) Nucleic Acids Res , vol.19 , pp. 3295-3300
    • Ryan, A.J.1    Squires, S.2    Strutt, H.L.3    Johnson, R.T.4
  • 33
    • 0029003314 scopus 로고
    • Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin
    • Kapoor R, Slade DL, Fujimori A, Pommier Y, Harker WG: Altered topoisomerase I expression in two subclones of human CEM leukemia selected for resistance to camptothecin. Oncol Res 1995;7:83-95.
    • (1995) Oncol Res , vol.7 , pp. 83-95
    • Kapoor, R.1    Slade, D.L.2    Fujimori, A.3    Pommier, Y.4    Harker, W.G.5
  • 36
    • 0027881702 scopus 로고
    • Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine
    • Benedetti P, Fiorani P, Capuani L, Wang JC: Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine Cancer Res 1993;53:4343-4348
    • (1993) Cancer Res , vol.53 , pp. 4343-4348
    • Benedetti, P.1    Fiorani, P.2    Capuani, L.3    Wang, J.C.4
  • 37
    • 0026772298 scopus 로고
    • Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F104864), a new camptothecin analogue
    • Hendricks CB, Rowinsky EK, Grochow LB, Donehower RC, Kaufmann SH: Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F104864), a new camptothecin analogue. Cancer Res 1992;52:2268-2278.
    • (1992) Cancer Res , vol.52 , pp. 2268-2278
    • Hendricks, C.B.1    Rowinsky, E.K.2    Grochow, L.B.3    Donehower, R.C.4    Kaufmann, S.H.5
  • 38
    • 0027813132 scopus 로고
    • In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells
    • Mattern MR, Hofmann GA, Polsky RM, Funk LR, McCabe FL, Johnson RK: In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells. Oncol Res 1993; 5:467-474.
    • (1993) Oncol Res , vol.5 , pp. 467-474
    • Mattern, M.R.1    Hofmann, G.A.2    Polsky, R.M.3    Funk, L.R.4    McCabe, F.L.5    Johnson, R.K.6
  • 40
    • 0024356642 scopus 로고
    • Characterization of adducts produced in DNA by isomeric 1,2-diaminocyclohexaneplatinum(II) complexes
    • Jennerwein MM, Eastman A, Khokhar AR: Characterization of adducts produced in DNA by isomeric 1,2-diaminocyclohexaneplatinum(II) complexes. Chem Biol Interact 1989;70:39-49.
    • (1989) Chem Biol Interact , vol.70 , pp. 39-49
    • Jennerwein, M.M.1    Eastman, A.2    Khokhar, A.R.3
  • 41
    • 0024373787 scopus 로고
    • Antitumor activity of a new platinum complex. Oxalato (trans-I-1,2-diaminocyclohexane)-platinum(II): New experimental data
    • Tashiro T, Kawada Y, Sakurai Y, Kidani Y: Antitumor activity of a new platinum complex. Oxalato (trans-I-1,2-diaminocyclohexane)-platinum(II): New experimental data. Biomed Pharmacother 1989;43 251-260
    • (1989) Biomed Pharmacother , vol.43 , pp. 251-260
    • Tashiro, T.1    Kawada, Y.2    Sakurai, Y.3    Kidani, Y.4
  • 43
    • 0001385726 scopus 로고    scopus 로고
    • Oxaliplatin (LOHP) and cisplatin (CDDP) in combination with 5FU, specific thymidylate synthase inhibitors (AG337, ZD1694), and topoisomerase I inhibitors (SN38, CPT-11), in human colonie, ovarian and breast cancer
    • abstract 1981
    • Raymond E, Djelloul S, Buquet-Fagot C, Goldwasser F, Mester J, Cvitkovic E, Louvet C, Gespach C Oxaliplatin (LOHP) and cisplatin (CDDP) in combination with 5FU, specific thymidylate synthase inhibitors (AG337, ZD1694), and topoisomerase I inhibitors (SN38, CPT-11), in human colonie, ovarian and breast cancer Proc Am Assoc Cancer Res 1996; 37:291(abstract 1981)
    • (1996) Proc Am Assoc Cancer Res , vol.37 , pp. 291
    • Raymond, E.1    Djelloul, S.2    Buquet-Fagot, C.3    Goldwasser, F.4    Mester, J.5    Cvitkovic, E.6    Louvet, C.7    Gespach, C.8
  • 45
    • 0003282883 scopus 로고    scopus 로고
    • Phase II study of a multi-targeted antifolate (LY231514) as first-line therapy in patients with locally advanced or metastatic colorectal cancer
    • abstract 949
    • Cripps MC, Burnell M, Joliver J, Lofters W, Fisher B, Panasci L, Iglesias J, Eisenhauer E: Phase II study of a multi-targeted antifolate (LY231514) as first-line therapy in patients with locally advanced or metastatic colorectal cancer. Proc Am Soc Clin Oncol 1997;16:267(abstract 949)
    • (1997) Proc Am Soc Clin Oncol , vol.16 , pp. 267
    • Cripps, M.C.1    Burnell, M.2    Joliver, J.3    Lofters, W.4    Fisher, B.5    Panasci, L.6    Iglesias, J.7    Eisenhauer, E.8
  • 50
    • 0000269364 scopus 로고    scopus 로고
    • Raltitrexed (Tomudex®) versus 5-fluorouracil and leucovorin (5-FU+LV) in patients with advanced colorectal cancer: Results of a randomized, multicenter
    • abstract 801
    • Pazdur R, Vincent M: Raltitrexed (Tomudex®) versus 5-fluorouracil and leucovorin (5-FU+LV) in patients with advanced colorectal cancer: Results of a randomized, multicenter. North American trial. Proc Am Soc Clin Oncol 1997;16:228a(abstract 801)
    • (1997) North American Trial. Proc Am Soc Clin Oncol , vol.16
    • Pazdur, R.1    Vincent, M.2
  • 51
    • 0000152038 scopus 로고    scopus 로고
    • Advanced colorectal cancer: Results from the latest Tomudex® (raltitrexed) comparative study
    • abstract 802
    • Harper P: Advanced colorectal cancer: Results from the latest Tomudex® (raltitrexed) comparative study. Proc Am Soc Clin Oncol 1997;16:228a (abstract 802).
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Harper, P.1
  • 56
    • 0001271895 scopus 로고
    • A phase II trial of CPT-11 (irinotecan) in patients with metastatic colorectal carcinoma: A North Central Cancer Treatment Group (NCCTG) study
    • abstract 573
    • Pitot HC, Wender D, O'Connell MJ, Wieand HS, Mailliard JA: A phase II trial of CPT-11 (irinotecan) in patients with metastatic colorectal carcinoma: A North Central Cancer Treatment Group (NCCTG) study Proc Am Soc Clin Oncol 1994;13:197(abstract 573).
    • (1994) Proc Am Soc Clin Oncol , vol.13 , pp. 197
    • Pitot, H.C.1    Wender, D.2    O'Connell, M.J.3    Wieand, H.S.4    Mailliard, J.A.5
  • 57
    • 0010285525 scopus 로고    scopus 로고
    • A phase II study of 9-aminocamptothecin in patients with fluorouracil-refractory colorectal cancer
    • abstract 456
    • Saltz L, Kemeny N, Soignet S, Quan V, Harrison J, Berkery R, Kelsen D: A phase II study of 9-aminocamptothecin in patients with fluorouracil-refractory colorectal cancer. Proc Am Soc Clin Oncol 1996;15 204(abstract 456)
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 204
    • Saltz, L.1    Kemeny, N.2    Soignet, S.3    Quan, V.4    Harrison, J.5    Berkery, R.6    Kelsen, D.7
  • 62
    • 0344698718 scopus 로고    scopus 로고
    • Phase II study of 21-day topotecan continuous infusion for metastatic colorectal cancer (ECOG study 4293)
    • abstract 1032
    • Hochster H, Ibrahim J, Liebes L, O'Dwyer P, Benson A: Phase II study of 21-day topotecan continuous infusion for metastatic colorectal cancer (ECOG study 4293). Proc Am Soc Clin Oncol 1997;16:290a(abstract 1032).
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Hochster, H.1    Ibrahim, J.2    Liebes, L.3    O'Dwyer, P.4    Benson, A.5
  • 63
    • 4243900833 scopus 로고    scopus 로고
    • A phase II trial of 9-amino-20(S) raltitrexed camptothecin (9-AC) in previously untreated patients with measurable metastatic colorectal carcinoma
    • abstract 1077
    • Pitot C, Knost JA, Mahoney MR, O'Connell MJ, Krook J: A phase II trial of 9-amino-20(S) raltitrexed camptothecin (9-AC) in previously untreated patients with measurable metastatic colorectal carcinoma. Proc Am Soc Clin Oncol 1997;16:303a (abstract 1077)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Pitot, C.1    Knost, J.A.2    Mahoney, M.R.3    O'Connell, M.J.4    Krook, J.5
  • 64
    • 0003282887 scopus 로고    scopus 로고
    • Clinical benefit or irinofecan (CPT-11) in metastatic colorectal cancer resistant to 5-FU
    • abstract 950
    • Van Cutsem E, Rougier Ph, Droz JP, Marty M, Bleiberg H Clinical benefit or irinofecan (CPT-11) in metastatic colorectal cancer resistant to 5-FU. Proc Am Soc Clin Oncol 1997;16:268a(abstract 950).
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Van Cutsem, E.1    Rougier, Ph.2    Droz, J.P.3    Marty, M.4    Bleiberg, H.5
  • 74
    • 7144227238 scopus 로고    scopus 로고
    • Phase I of a weekly schedule of irinotecan (CPT-11) in combination with high-dose folinic acid and 5-fluorouracil as first-line chemotherapy in patients with advanced colorectal cancer
    • abstract 967
    • Vanhoefer U, Harstrick A, Müller C, Achterrath W, Könne CH, Krauss C, Preusser PW, Wilke H, Seeber S: Phase I of a weekly schedule of irinotecan (CPT-11) in combination with high-dose folinic acid and 5-fluorouracil as first-line chemotherapy in patients with advanced colorectal cancer. Proc Am Soc Clin Oncol 1997;16:272a(abstract 967)
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Vanhoefer, U.1    Harstrick, A.2    Müller, C.3    Achterrath, W.4    Könne, C.H.5    Krauss, C.6    Preusser, P.W.7    Wilke, H.8    Seeber, S.9
  • 75
    • 0000033490 scopus 로고
    • Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil
    • abstract 2260
    • Van der Wilt CL, Pinedo HM, Kuiper CM, Smid K, Peters GJ: Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil. Proc Am Assoc Cancer Res 1995;36:379(abstract 2260).
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 379
    • Van Der Wilt, C.L.1    Pinedo, H.M.2    Kuiper, C.M.3    Smid, K.4    Peters, G.J.5
  • 76
    • 0030771521 scopus 로고    scopus 로고
    • The role of second-line chemotherapy in colorectal cancer
    • Schmoll JH, Büchele T, Schober C: The role of second-line chemotherapy in colorectal cancer Onkologie 1997;20:288-294
    • (1997) Onkologie , vol.20 , pp. 288-294
    • Schmoll, J.H.1    Büchele, T.2    Schober, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.