Human olfactory mucosa in schizophrenia

Annals of Otology, Rhinology and Laryngology

Volumn 107, Issue 4, 1998, Pages 349-355

  Smutzer, Gregory ^a   Lee, Virginia M Y ^a   Trojanowski, John Q ^a   Arnold, Steven E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cytoskeleton; Dystrophic neurites; Olfactory epithelium; Schizophrenia

Indexed keywords

CYTOSKELETON PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 5; NEUROFILAMENT PROTEIN; SYNAPTOPHYSIN;

AGED; ARTICLE; AUTOPSY; CONTROLLED STUDY; DYSTROPHY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEURITE; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 7144257838     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348949810700415     Document Type: Article

References (45)

1. Doty RL. Olfactory dysfunction in neurodegenerative disorders. In: Getchell TV, ed. Smell in health and disease. New York, NY: Raven Press, 1992:735-51.
2. Rezek DL. Olfactory deficits as a neurologic sign in dementia of the Alzheimer type. Arch Neurol 1987;44:1030-2.
3. Doty RL, Snow JB Jr. Olfaction. In: Golman J, ed. The principles and practice of rhinology. New York, NY: Wiley, 1987:761-85.
4. Doty RL, Reyes PF. Gregor T. Presence of both odor identification and detection deficits in Alzheimer's disease. Brain Res Bull 1987;18:597-600.
5. Doty RL, Riklan M, Deems DA, Reynolds C, Stellar S. The olfactory and cognitive deficits of Parkinson's disease. Evidence for independence. Ann Neurol 1989;25:166-71.
6. Talamo BR, Rudel R, Kosik KS, et al. Pathological changes in olfactory neurons in patients with Alzheimer's dis- ease. Nature 1989;337:736-9.
7. Trojanowski JQ, Newman PD, Hill WD, Lee VM-Y. Human olfactory epithelium in normal aging, Alzheimer's disease, and other neurodegenerative disorders. J Comp Neurol 1991;310:365-76.
8. Lee JH, Goedert M, Hill WD, Lee VM-Y, Trojanowski JQ. Tau proteins arc abnormally expressed in olfactory epithelium of Alzheimer patients and developmentally regulated in human fetal spinal cord. Exp Neurol 1993;121:93-105.
9. Crino PB, Martin JA, Hill WD, Greenberg B, Lee VMY, Trojanowski JQ. ß-Amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with Alzheimer's disease, Parkinson's disease, and Down syndrome. Ann Otol Rhinol Laryngol 1995;104:655-61.
10. Lee VM-Y, Trojanowski JQ. The disordered neuronal cytoskeleton in Alzheimer's disease. Curr Opin Neurobiol 1992; 2:653-6.
11. Chen J, Kanai Y, Cowan N, Hirokawa N. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature 1992;360:674-7.
12. Hurwitz T, Kopala L, Clark C, Jones B. Olfactory deficits in schizophrenia. Biol Psychiatry 1988;23:123-8.
13. Kopala L, Clark C, Hurwitz TA. Sex differences in olfactory function in schizophrenia. Am J Psychiatry 1989;146:1320-2.
14. Kopala LC, Clark CC, Bassett A. Olfactory deficits in schizophrenia and chromosome 5 [Letter]. Biol Psychiatry 1991;29:732-3.
15. Moberg PJ, Doty RL, Turetsky BI, et al. Olfactory identification deficits in schizophrenia: correlation with duration of illness. Am J Psychiatry 1997;154:1016-8.
16. Moberg PJ, Doty RL, Mahr RN, et al. Olfactory identification in elderly schizophrenia and Alzheimer's disease. Neurobiol Aging 1997;18:163-7.
17. Kopala LC, Clark C, Hurwitz T. Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophr Res 1993;8:245-50.
18. Arnold SE, Lee VM-Y, Gur RE, Trojanowski JQ. Abnormal expression of two microtubule-associated proteins (MAP2 and MAP5) in specific subfields of the hippocampal formation in schizophrenia. Proc Natl Acad Sci U S A 1991;88:10850-4.
19. Arnold SE, Hyman BT, Van Hoesen GW, Damasio AR. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch Gen Psychiatry 1991;48:625-32.
20. Bourgeois J-P, Rakic P. Changes of synaptic density in the primary visual cortex of the macaque monkey from fetal to adult stage. J Neurosci 1993;13:2801-20.
21. Benes FM, Neurological investigations in cingulate cortex of schizophrenic brain. Schizophr Bull 1993;19:537-49.
22. Honer WG, Squires-Wheeler E, Smith GN, Sharif Z, Chan S, Gewirtz G. Developmental abnormalities and cortical sulcal enlargement in psychosis, Schizophr Res 1995;16:121-5.
23. Graziadei PP. Cell dynamics in the olfactory mucosa. Tissue Cell 1973;5:113-31.
24. Moulton DG. Dynamics of cell populations in the olfactory epithelium. Ann N Y Acad Sci 1974;237:52-61.
25. Arnold SE, Gur RE, Shapiro RM, et al. Prospective clinicopathologic studies of schizophrenia: accrual and assessment of patients. Am J Psychiatry 1995;152:731-7.
26. Tonnaer EL, Kuipers W, Peters TA, Radmakers FC. Effect of EDTA on cytokeratin detection in the inner ear. J Histochem Cytochem 1990;38:1223-7.
27. Lee VM-Y, Page CD, Wu H-L, Schlaepfer WW. Monoclonal antibodies to gel excised glial filament protein and their reactivities with other intermediate filament proteins. J Neurochem 1984;42:25-32.
28. Lee VM-Y, Garden MJ, Schlaepfer WW, Trojanowski JQ. Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats. J Neurosci 1987;7:3474-88.
29. Schmidt ML, Garden MJ, Lee VM-Y, Trojanowski JQ. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls. Lab Invest 1987;56:282-94.
30. Lee VM-Y, Otvos L Jr, Schmidt ML, Trojanowski JQ. Alzheimer disease tangles share immunological similarities with multiphosphorylation repeats in the two large neurofilament proteins. Proc Natl Acad Sci U S A 1988;85:7384-8.
31. Kosik KS, Orrechio LD, Binder L, Trojanowski JQ, Lee VM-Y, Lee G. Epitopes that span the tau molecule are shared with paired helical filaments. Neuron 1988;1:817-25.
32. Lee VM-Y, Balin BJ, Otvos L Jr, Trojanowski JQ. A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 1991;251:675-8.
33. Ross AH, Grob P, Bothwell M, et al. Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies, Proc Natl Acad Sci U S A 1984;81:6681-5.
34. Schmidt ML, Lee VM-Y, Trojanowski JQ. Relative abundance of tau and neurofilament epitopes in hippocampal neurofibrillary tangles. Am J Pathol 1990;136:1069-75.
35. Wilkinson KD, Lee K, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science 1989;246:670-3.
36. Doran JF, Jackson P, Kynoch PA, Thompson RJ. Isolation of PGP 9.5, a new human neurone-specific protein detected by high-resolution two-dimensional electrophoresis. J Neurochem 1983;40:1542-7.
37. Getchell TV, Rama Krishna NS, Dhooper N, Sparks DL, Getchell ML. Human olfactory receptor neurons express heat shock protein 70: age-related trends. Ann Otol Rhinol Laryngol 1995;104:47-56.
38. Rama Krishna NS, Getchell ML, Buiakova OI, Margolis FL, Getchell TV. Human olfactory receptor neurons contain OMP mRNA in their dendritic and axonal processes. Neuroreport 1995;6:817-21.
39. Matus A, Riederer B. Microtubule-associaled proteins in the developing brain. Ann N Y Acad Sci 1986;466:167-79.
40. Schumacher U, Mitchell BS, Kaiserling E. The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors. DNA Cell Biol 1994;13:839-43.
41. Carrell RW. Alzheimer's disease. Enter a protease inhibitor. Nature 1988;331:478-9.
42. Roskams AJI, Bethel MA, Hurt KJ, Ronnett GV. Sequential expression of Trks A, B, and C in the regenerating olfactory neuroepithelium. J Neurosci 1996;16:1294-307.
43. Vassar R, Chao SK, Sitcheran R, Nunez JM, Vosshall LB, Axel R. Topographic organization of sensory projections to the olfactory bulb. Cell 1994;79:981-91.
44. Ressler KJ, Sullivan SL, Buck LB. Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 1994;79:1245-55.
45. Sullivan SL, Bohm S, Ressler KJ, Horowitz LF, Buck LB. Target-independent pattern specification in the olfactory epithelium. Neuron 1995;15:779-89.