Novel mode of action of the calcium antagonist mibefradil (Ro 40-5967): Potent immunosuppression by inhibition of T-cell infiltration through allogeneic endothelium

Immunology

Volumn 94, Issue 2, 1998, Pages 213-220

  Blaheta, R A ^a,d   Hailer, N P ^b   Brude, N ^a   Wittig, B ^c   Oppermann, E ^a   Leckel, K ^a   Harder, S ^a   Scholz, M ^a   Weber, S ^a   Encke, A ^a   Markus, B H ^a  

^a GOETHE UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ANTAGONIST; CYCLOSPORIN A; MIBEFRADIL;

ARTICLE; CELL INFILTRATION; CELL MIGRATION; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; T LYMPHOCYTE;

ACTINS; BENZIMIDAZOLES; CALCIUM CHANNEL BLOCKERS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL ADHESION MOLECULES; CELL CULTURE TECHNIQUES; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MIBEFRADIL; T-LYMPHOCYTE SUBSETS; TETRAHYDRONAPHTHALENES;

EID: 7144251199     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00504.x     Document Type: Article

References (37)

1. CLOZEL J.P., VENIANT M. & OSTERRIEDER W. ( 1990) The structurally novel Ca2+ channel blocker Ro 40-5967, which binds to the [3H] desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts. Cardiovasc Drugs Ther 4, 731.
2. SCHMITT R., KEINBLOESM C.H., BELZ G.G. et al. (1992) Hemodynamic and humoral effects of the novel calcium antagonist Ro 40-5967 in patients with hypertension. Clin Pharmacol Ther 52, 314.
3. PETRIE J.R., GLEN S.K., MACMAHON M. et al. (1995) Haemodynamics, cardiac conduction and pharmacokinetics of mibefradil (Ro 40 5967), a novel calcium antagonist. J Hypertens 13, 1842.
4. BRAUN S., VAN DER WALL E.E., EMANUELSSON H. & KOBRIN I. (1996) Effects of a new calcium antagonist, mibefradil (Ro 40-5967), on silent ischemia in patients with stable chronic angina pectoris: a multicenter placebo-controlled study. J Am Coll Cardiol 27, 317.
5. BAKX A.L., VAN DER WALL E.E., BRAUN S., EMANUELSSON H., BRUSCHKE A.V. & KOBRIN I. (1995) Effects of the new calcium antagonist mibefradil (Ro 40-5967) on exercise duration in patients with chronic stable angina pectoris: a multicenter, placebo-controlled study. Am Heart J 130, 748.
6. HEFTI F., CLOZEL J.P. & OSTERRIEDER W. (1990) Antihypertensive properties of the novel calcium antagonist (1S, 2S)-2-[2-[[3-(2-benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1 2 (3), 4-tetrahydro-1-isopropyl-2-naphtyl methoxyacetatedihydrochloride in rat models of hypertension. Comparison with verapamil. (1990) Arzneim-Forsch 40, 417.
7. BRUSERUD O., NESTHUS I. & PAWELEC G. (1995) In vitro effect of R-verapamil on acute myelogenous leukemia blast cells; studies of cytokine secretion and cytokine-dependent blast proliferation. Cancer Chemother Pharmacol 37, 70.
8. WEIR M.R., PEPPLER R., GOMOLKA D. & HANDWERGER B.S. (1993) Calcium channel blockers inhibit cellular uptake of thymidine, uridine and leucin: the incorporation of these molecules into DNA, RNA and protein in the presence of calcium channel blockers is not a valid measure of lymphocyte activation. Immunopharmacology 25, 75.
9. ZANKER B., MARX S., STROM T.B. & KOHLER H. (1994) The immunosuppressive effects of verapamil upon mitogen activated and allo-antigen inducible human cytotoxic T-lymphocytes. Int J Immunopharmacol 16, 507.
10. TESI R.J., HONG J., BUTT K.M.H., JAFFE B.M. & MCMILLEN M.A. (1987) In vivo potentiation of cyclosporin immunosuppression by calcium antagonists. Transplant Proc 19, 1382.
11. MCMILLEN M.A., TESI R.J., BAUMGARTEN W.B., JAFFE B.M. & WAIT R.B. (1985) Potentiation of cyclosporin by verapamil in vitro. Transplantation 40, 444.
12. SCHRIER R.W. & BURKE T.J. (1991) Role of calcium-channel blockers in preventing acute and chronic renal injury. J Cardiovasc Pharmacol 18, S38.
13. DAWIDSON I., ROOTH P., FRY W.R et al. (1989) Prevention of acute cyclosporin-induced renal blood flow inhibition and improved immunosuppression with verapamil. Transplantation 48, 575.
14. PALMER B.F., DAWIDSON I., SAGALOWSKY A., SANDOR Z. & LU C. (1991) Improved outcome of cadaveric renal transplantation due to calcium channel blockers. Transplantation 52, 640.
15. BLAHETA R.A., HARDER S., HAILER N.P. et al. (1994) Effect of the calcium channel blockers S-, R- Verapamil and Ro 40-5967 on adhesion and migration properties of lymphocytes acting on human vascular endothelium. Endothelium 1, 295.
16. BLAHETA R.A., SCHOLZ M., BEREITER-HAHN J., ENCKE A. & MARKUS B.H. (1992) Influence of immunosuppressive drugs on adhesion and migration of allogeneic lymphocytes through vascular endothelial cells. Eur J Cell Biol 57, 9.
17. BLAHETA R.A., SCHOLZ, M., HAILER N.P., BEREITER-HAHN J., ENCKE A. & MARKUS B.H. (1994) Adhesion and penetration properties of human lymphocytes acting on allogeneic vascular endothelial cells. Immunology 81, 538.
18. BEREITER-HAHN J., FOX C.H. & THORELL B. (1979) Quantitative reflection contrast microscopy of living cells. J Cell Biol 82, 767.
19. GINGELLL D. & TODD J. (1979) Interference reflection microscopy: a quantitative theory for image interpretation and its application to cell-substratum separation measurement. Biophys J 26, 507.
20. HAILER N.P., BLAHETA R.A., HARDER S., SCHOLZ, M. & MARKUS B.H. (1994) Influence of calcium channel blockers on adhesion molecule expression and lymphocyte motility. Tx Med 6, 121.
21. HAILER N.P., BLAHETA R.A., HARDER S., SCHOLZ M. ENCKE A. & MARKUS B.H. (1994) In-vitro-investigations on immunosuppression with verapamil. Zentralbl Chir 119, 347.
22. WALZ G., ARRUFO A., KOLANUS W., BEVILACQUA M.P. & SEED B. (1990) Recognition by ELAM-1 of the sialyl Lewis x determinant on myeloid and tumor cells. Science 250, 1332.
23. ZETTLMEISSEL G., GREGERSEN J.P., DUPORT J.M., MEHDI S., REINER G. & SEED B. (1990) Expression and characterization of human CD4: immunoglobulin fusion protein. DNA Cell Biol 9, 347.
24. WITTIG B.M., THEES R., KAULEN H. et al. (1996) α1, 3 Fucosyltransferase expression in E-selectin-mediated binding of gastrointestinal tumor cells. Int J Cancer 67, 80.
25. BACON K.B., WESTWICK J. & CAMP R.D.R. (1989) Potent and specific inhibition of IL-8-, IL-1α and IL-1β-induced in vitro human lymphocyte migration by calcium channel antagonists. Biochem Biophys Res Commun 165, 349.
26. KRUPINSKI K., BREDDIN H. & BIELAWIEC M. (1993) Antithrombotic effects of molsidomine, isosorbide dinitrate and verapamil in a laser-induced thrombosis model. Kardiol Pol 39, 100.
27. YOHEM K.H., CLOTHIER J.L., MONTAGUE S.L. et al. (1991) Inhibition of tumor cell invasion by verapamil. Pigm Cell Res 4, 225.
28. D'ANCONA S., PEA F. & MAZZO M. (1992) The effect of dilazep on F10 cells in vitro. Anticancer Res 12, 631.
29. LOPEZ-NEBLINA F., PAEZ-ROLLYS A.J. & TOLEDO-PEREYRA L.H. (1996) Mechanism of protection of verapamil by preventing neutrophil infiltration in the ischemic rat kidney. J Surg Res 61, 469.
30. BERTUGLIA S., COLANTUONI A. & INTAGLIETTA M. (1993) Effect of leukocyte adhesion and microvascular permeability on capillary perfusion during ischemia-reperfusion injury in hamster check pouch. Int J Microcirc Clin Exp 13, 13.
31. TONNEL A.B., GOSSET P., MOLET S. et al. (1996) Interactions between endothelial cells and effector cells in allergic inflammation. Ann NY Acad Sci 796, 9.
32. MCMURRAY R.W. (1996) Adhesion molecules in autoimmune disease. Semin Arthritis Rheum 25, 215.
33. + T-lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow. J Exp Med 181, 1179.
34. DUSTIN M.L. & SPRINGER T.A. (1989) T-cell receptor cross-linking transiently stimulates adhesiveness through LFA 1. Nature 341, 619.
35. POUYANI T. & SEED B. (1995) PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus. Cell 83, 333.
36. SAKO D., COMESS K.M., BARONE K.M., CAMPHAUSEN R.T., CUMMING D.A. & SHAW G.D. (1995) A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding. Cell 83, 323.
37. ELFERINK J.G. & DE KOSTER B.M. (1994) Endothelin-induced activation of neutrophil migration. Biochem Pharmacol 48, 865.