Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist

British Journal of Pharmacology

Volumn 124, Issue 1, 1998, Pages 83-92

  Walpole, C S J ^a   Brown, M C S ^a   James, I F ^a   Campbell, E A ^a   McIntyre, P ^a   Docherty, R ^a   Ko, S ^a   Hedley, L ^a   Ewan, S ^a   Buchheit, K H ^a   Urban, L A ^a  

^a Novatis Inst for Medical Sciences   (United Kingdom)

Author keywords

General pharmacology; In vitro; NK1; Non peptide antagonist; Receptor

Indexed keywords

2 NITROPHENYLCARBAMOYLPROLYL 3 (2 NAPHTHYL)ALANYL N BENZYL N METHYLAMIDE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 4 (2 METHOXYPHENYL) 2 [2 (2 METHOXYPHENYL)PROPIONYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 OL; ADRENERGIC RECEPTOR; BRADYKININ B2 RECEPTOR; CALCIUM ION; HISTAMINE H1 RECEPTOR; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NOLPITANTIUM; OPIATE RECEPTOR; SUBSTANCE P; SULFONE; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

AIRWAY RESISTANCE; ANIMAL CELL; ARTICLE; BINDING SITE; BRONCHOSPASM; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENANTIOMER; FOREBRAIN; GUINEA PIG; HEART RATE; HUMAN; ILEUM; MEAN ARTERIAL PRESSURE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; SMOOTH MUSCLE CONTRACTION; SODIUM CURRENT; SPINAL GANGLION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; COS CELLS; DNA PRIMERS; GANGLIA, SPINAL; GERBILLINAE; GUINEA PIGS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NAPHTHALENES; PROLINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECOMBINANT PROTEINS; SUBSTANCE P;

EID: 7144251188     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701806     Document Type: Article

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