High density culture of immortalized liver endothelial cells in the radial-flow bioreactor in the development of an artificial liver

International Journal of Artificial Organs

Volumn 21, Issue 4, 1998, Pages 229-234

  Matsuura, T ^a   Kawada, M ^a   Hasumura, S ^a   Nagamori, S ^a   Obata, T ^a   Yamaguchi, M ^a   Hataba, Y ^a   Tanaka, H ^a   Shimizu, H ^a   Unemura, Y ^a   Nonaka, K ^a   Iwaki, T ^a   Kojima, S ^b   Aizaki, H ^c   Mizutani, S ^d   Ikenaga, H ^d  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RIKEN TSUKUBA INSTITUTE   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d KIRIN BREWERY CO LTD   (Japan)

Author keywords

Artificial liver; Bioreactor; Immortalized cells; Liver endothelial cells; Radial flow; Transgenic mouse

Indexed keywords

ARTIFICIAL ORGANS; BIOCONVERSION; BIOREACTORS; CELL CULTURE; CELL ENGINEERING; CELL MEMBRANES; CLONING; MAMMALS; MICROCIRCULATION;

ARTIFICIAL LIVER; BIOREACTOR; CELL-BE; CELL/B.E; ENDOTHELIAL-CELLS; HIGH-DENSITY CULTURES; IMMORTALIZED CELLS; LIVER ENDOTHELIAL CELL; RADIAL-FLOW BIOREACTORS; TRANSGENIC MICE;

ENDOTHELIAL CELLS;

ACETYL LOW DENSITY LIPOPROTEIN; GAMMA INTERFERON; MESSENGER RNA; PLASMINOGEN ACTIVATOR; PROSTACYCLIN; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL LIVER; BIOREACTOR; CELL CLONE; CELL CULTURE; CELL DENSITY; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; LIVER SINUSOID; MOUSE; NONHUMAN; SIMIAN VIRUS 40; TRANSGENIC MOUSE;

EID: 7144229367     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.1177/039139889802100410     Document Type: Article

References (16)

1. Smedsrad M, Pertoft G, Gustafson S, Laurent T.C. Scavenger functions of the liver endothelial cell. Biochem J 1990: 266: 313-27.
2. Kawada M, Nagamori S, Aizaki H, et al. A new liver support system composed of functional human cells and a radial-flow bioreactor. Human Cell 1994; 7: 95-100.
3. b-tsA58 transgenic mouse. Proc Natl Acad Sci USA. 1991; 88: 5096-100.
4. Matsuura T, Nagamori S, Fujise K, et al. Retinol transport in cultured fat-storing cells of rat liver. Quantitative analysis by anchored cell analysis and sorting system. Lab Invest 1989; 61: 107-15.
5. Obata T, Nagakura T, Kammuri M, Masaki T, Maekawa K, Yamashita K. Determination of 9α, 11β-prostaglandin F2 in human urine and plasma by gas chromatography-mass spectrometry. J Chromatography B 1994; 655: 173-8.
6. Bjorling DE, Saben R, Tengowski MW, Removal of venous endothelium with air. J Pharm and Toxicology Method 1992; 28: 149-57.
7. Kojima S, Muramatsu H, Amanuma H, Maramatsu T. Midkine enhances fibrinolytic activity of bovine endothelial cells. J Biol Chem 1995; 270: 9590-6.
8. Yamaguchi M, Hirano T, Tachibana T, Tanaka A. Electron microscopy of surface antigens of yeast protoplasts by the plasma polymerizaton-film extraction replica mthod. J Electron Microsc 1985; 34: 169-73.
9. Kawada M, Nagamori S, Aizaki H, et al. Massive culture of human liver cancer cells in a newly developed radial flow bioreactor system: Ultrafine strcture of functionally-enhanced hepatocarcinoma cells lines. In Vitro Cell Develop Biol 1998: 34.
10. Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CRH. Recognition and plasma clearance of endotoxin by scavenger receptors. Nature 1991; 352: 342-4.
11. Perry A, Ofek I. Inhibition of blood clearance and hepatic tissue binding of Escherichia Coli by liver lectin-specific sugar and glycoproteins. Infet Immun 1984; 43: 257-62.
12. Wilson ME, Peterson RD. Evidence that Leishmania donovani utilizes a mannose receptor on human mononuclear phagocytes to establish intracellular parasitism. J Immunol 1986; 136: 4681-8.
13. 2 analog in treatment of massive hepatic necrosis associated with endothelial cell injury and diffuse sinusoidal fibrin deposition. Digestive Diseases and Sciences 1995; 40: 41-7.
14. Matsuura T, Nagamori S, Hasamura S, et al. Retinol transport in cultured stellate cells of rat liver. Studies by light and electron microscope autoradiography. Exp Cell Res 1993; 206: 111-8.
15. Roberts MF. Phospholipases: structural and functional motifs for working at an interface. FASEB J 1996; 10: 1159-72.
16. Wisse E. (1970) An electron microscopic study of the fenestrated endothelial lining of rat lvier sinusoids. J Ultrastruct Res 1970; 31: 125-50.