Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression

Endocrine Journal

Volumn 45, Issue SUPPL., 1998, Pages

  Yamauchi, Toshimasa ^a   Ueki, Kohjiro ^a   Tobe, Kazuyuki ^a   Tamemoto, Hiroyuki ^a   Sekine, Nobuo ^a   Wada, Mitsufumi ^b   Honjo, Masaru ^b   Takahashi, Michio ^c   Takahashi, Tokiharu ^a   Hirai, Hisamaru ^a   Tsushima, Toshio ^d   Akanuma, Yasuo ^e   Fujita, Toshiro ^a   Komuro, Issei ^a   Yazaki, Yoshio ^a   Kadowaki, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MITSUI CHEMICALS INC   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^e INSTITUTE FOR ADULT DISEASES   (Japan)

Author keywords

Epidermal growth factor receptor; GH; JAK2 tyrosine kinase; MAP kinase

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH HORMONE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION REGULATION; GROWTH HORMONE RELEASE; NONHUMAN; ONCOGENE C FOS; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 7144227948     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.45.suppl_s27     Document Type: Article

References (25)

1. Ridderstrale M, Degerman E, Tornqvist H (1995) Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes. J Biol Chem 270: 3471-3474.
2. Argetsinger LS, Hsu GW, Myers MG Jr, Billestrup N, White MF, Carter-Su C (1995) Growth hormone, intereron-γ, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem 270: 14685-14692.
3. Argetsinger LS, Norstedt G, Billestrup N, White MF, Carter-Su C (1996) Growht hormone, interferon-γ, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling. J Biol Chem 271: 29415-29421.
4. Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, Wada M, Honjo M, Takahashi M, Takahashi T, Hirai H, Tushima T, Akanuma Y, Fujita T, Komuro I, Yazaki Y, Kadowaki T (1997) Tyrosine-phosphorylation of the EGF receptor by the Jak2 kinase is induced by growth hormone. Nature 390: 91-96.
5. Honegger AM, Dull TJ, Felder S, Van-Obberghen E, Bellot F, Szaparz D, Schmidt A, Ullrich A (1987) Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing. Cell 51: 199-209.
6. Okutani T, Okabayashi Y, Kido Y, Sugimoto Y, Sakaguchi K, Matuoka K, Takenawa T, Kasuga M (1994) Grb2/Ash binds directly to tyrosine 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. J Biol Chem 269: 31310-31314.
7. Chen C, Clarkson RWE, Xie Y, Hume DA, Waters JM (1995) Growth hormone and colony-stimulating factor-1 share multiple response elements in the c-fos promoter. Endocrinology 136: 4505-4516.
8. Wen Z, Zhong Z, Darnell, JE Jr (1995) Maximal activation of transcription by Stat 1 and Stat 3 requires both tyrosine and serine phosphorylation. Cell 82: 241-250.
9. Gille H, Sharrocks AD, Shaw PE (1992) Phosphorylation of trarnscription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358: 414-417.
10. Frank SJ, Yi W, Zhao Y, Goldsmith JF, Gilliland G, Jiang J, Sakai I, Kraft, AS (1995) Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor. J Biol Chem 270: 147765-14785.
11. Winston LA, Hunter T (1995) JAK2, Ras, Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth hormone. J Biol Chem 270: 30837-30840.
12. Han Y, Leaman DW, Walting D, Rogers NC, Groner B, Kerr IM, Wood WI, Stark GR (1996) Participation of JAK and STAT proteins in growth hormone-inducing signaling. J Biol Chem 271: 5947-5952.
13. Ihle JN (1996) STATs and MAPKs: obligate or opportunistic partners in signaling. Bioessays 18: 95-98.
14. Watanabe S, Itoh T, Arai K (1996) JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony stimulating factor receptor in BA/F3 cells. J Biol Chem 271: 12681-12686.
15. Argesinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O (1993) Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell 74: 237-244.
16. Batzer AG, Rotin D, Urena JM, Skolnik EY, Schlessinger J (1994) Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol 14: 5192-5201.
17. Behringer RR, Lewin TM, Quaife CJ, Palmiter RD, Brinster RL, D'Ercole AJ (1990) Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone deficient mice. Endocrinology 127: 1033-1040.
18. Sekine N, Ullrich S, Regazzi R, Pralong WF, Wollheim CB (1996) Postreceptor signaling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1. Endocrinology 137: 1841-1850.
19. Threadgill DW, Dlugosz AA, Hansen LA, Tennen Bauum T, Lichti Y, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Parnard JA, Yuspa SA, Coffey RJ, Magnuson T (1995) Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 269: 230-234.
20. Sibilia M, Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269: 234-238.
21. Miettinen PJ, Berger JE, Meneses J, Phun Y, Pedersen RA, Web Z, Derynck P (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376: 337-341.
22. Fowler KJ, Walker F, Alexander W, Hibbs ML, Nice EC, Bohmer RM, Mann GB, Thumwood C, Maglitto R, Danks JA, Chetty R, Burgess AW, Dunn, AR (1996) A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci USA 92: 1465-1469.
23. Sachsenmaier C, Radler-Pohl A, Zinck R, Nordheim A, Herrlich P, Rahmsdorf HJ (1994) Involvement of growth factor receptors in the mammalian UVC response. Cell 78: 963-972.
24. Daub H, Weiss FU, Wallasch C, Ullrich A (1996) Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379: 557-560.
25. Luttrell LM, Rocca GJD, Biesen TV, Luttrel DK, Lefkowitz RJ (1997) Gβγ subunits mediate src-dependent phosphorylation of the epidermal growth factor receptor. J Biol Chem 272: 4637-4644.