Foxn1 is essential for vascularization of the murine thymus anlage

Cellular Immunology

Volumn 260, Issue 2, 2010, Pages 66-69

  Mori, Kazuya ^a   Itoi, Manami ^a   Tsukamoto, Noriyuki ^a   Amagai, Takashi ^a  

^a MEIJI UNIVERSITY OF INTEGRATIVE MEDICINE   (Japan)

Author keywords

Epithelial cell; ERTR7; Foxn1; Mesenchymal cell; Nude; PDGFR ; Thymus anlage; VEGF

Indexed keywords

CD31 ANTIGEN; CELL PROTEIN; PROTEIN FOXN1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; FEMALE; MALE; MESENCHYME CELL; NONHUMAN; ORGANOGENESIS; PRIMORDIUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; THYMUS; VASCULARIZATION; WILD TYPE;

ANIMALS; ANTIGENS, CD31; BLOOD VESSELS; CELL MOVEMENT; EMBRYO, MAMMALIAN; ENDOTHELIAL CELLS; EPITHELIAL CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MESODERM; MICE; MICE, INBRED C57BL; MICE, NUDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS; THYMUS GLAND; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MURINAE; MUS;

EID: 71349086796     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2009.09.007     Document Type: Article

References (17)

1. Kuure S., Vuolteencho R., and Vainio S. Kidney morphogenesis: cellular and molecular regulation. Mech. Dev. 92 (2000) 31-45
2. Porto F., Mariotti A., Ilardi M., Messina F.R., Afeltra A., and Amoroso A. Kidney vasculogenesis and angiogenesis: role of vascular endothelial growth factor. Eur. Rev. Med. Pharmacol. Sci. 3 (1999) 149-153
3. Akeson A.L., Wetzel B., Thompson F.Y., Brooks S.K., Paradis H., Gendron R.L., and Greenberg J.M. Embryonic vasculogenesis by endothelial precursor cells derived from lung mesenchyme. Dev. Dyn. 217 (2000) 11-23
4. Matsumoto K., Yoshitomi H., Rossant J., and Zaret K.S. Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294 (2001) 559-563
5. Cordier A.C., and Haumout S.M. Development of thymus, parathyroids, and ultimo-branchial bodies in NMRI and nude mice. Am. J. Anat. 157 (1980) 227-276
6. Gordon J., Bennett A.R., Blackburn C.C., and Manley N.R. Gcm2 and Foxn1 mark early parathyroid- and thymus-specific domains in the developing third pharyngeal pouch. Mech. Dev. 103 (2001) 141-143
7. Itoi M., Tsukamoto N., and Amagai T. Expression of Dll4 and CCL25 in Foxn-1 negative epithelial cells in the post-natal thymus. Int. Immunol. 19 (2007) 127-132
8. Itoi M., Kawamoto H., Katsura Y., and Amagai T. Two distinct steps of immigration of hematopoietic progenitors into the earlythymus anlage. Int. Immunol. 13 (2001) 1203-1211
9. Amagai T., Itoi M., and Kondo Y. Limited development capacity of the earliest embryonic murine thymus. Eur. J. Immunol. 25 (1995) 757-762
10. Petrie H.T. Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production. Immunol. Rev. 189 (2002) 8-19
11. Mori K., Itoi M., Tsukamoto N., Kubo H., and Amagai T. The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma. Int. Immunol. 19 (2007) 745-753
12. Anderson M., Anderson S.K., and Farr A.G. Thymic vasculature: prganizer of the medullary epithelial compartment. Int. Immunol. 12 (2000) 1105-1110
13. Muller S.M., Terszowski G., Blum C., Haller C., Anquez V., Kuschert S., Carmelie P., Augustin H.G., and Rodewald H.R. Gene targeting of VEGF-A in thymus epithelium disrupts thymus blood vessel architecture. Proc. Natl. Acad. Sci. USA 102 (2005) 10587-10592
14. Nehls M., Pfeifer D., Schorpp M., Hedrich H., and Boehm T. New member of the winged-helix protein family disrupted in mouse and rat nude mutation. Nature 372 (1994) 103-107
15. Tsukamoto N., Itoi M., Nishikawa M., and Amagai T. Lack of Delta like 1 and 4 expressions in nude thymus anlages. Cell. Immunol. 234 (2005) 77-80
16. Gray D.H.D., Chidgey A.P., and Boyd R.L. Analysis of thymic stromal cell populations using flow cytometry. J. Immunol. Methods 260 (2002) 15-28
17. Itoi M., Tsukamoto N., Yoshida H., and Amagai T. Mesenchymal cells are required for functional development of thymic epithelial cells. Int. Immunol. 19 (2007) 953-964