Interference of the noradrenergic neurotoxin DSP4 with neuronal and nonneuronal monoamine transporters

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 6, 2009, Pages 523-529

  Wenge, Birger ^a   Bönisch, Heinz ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

DAT; DSP4; NAT; Neuronal monoamine transporter; Noradrenergic neurotoxin; OCTs; Organic cation transporter; SERT

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; DOPAMINE TRANSPORTER; NORADRENALIN TRANSPORTER; ORGANIC CATION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; SEROTONIN TRANSPORTER;

ARTICLE; CATION TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50;

ADENOSINE TRIPHOSPHATE; BENZYLAMINES; CELL LINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; NEUROTRANSMITTER UPTAKE INHIBITORS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; ORGANIC CATION TRANSPORT PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TOXICITY TESTS;

EID: 71349085348     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0459-z     Document Type: Article

References (29)

1. P Boksa D Aitken M Meaney 1989 Effects of the catecholaminergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on adrenal chromaffin cells in culture Biochem Pharmacol 38 1491 1498 10.1016/0006-2952(89) 90189-5 1:CAS:528:DyaL1MXktlCku7Y%3D 2719722 (Pubitemid 19123341)
2. 3H-desipramine to the neuronal noradrenaline carrier of rat phaeochromocytoma cells (PC-12 cells) Naunyn-Schmiedebergs Arch Pharmacol 334 403 411 10.1007/BF00569378 3821933 (Pubitemid 17056385)
3. H Bönisch M Brüss 2006 The norepinephrine transporter in physiology and disease Handb Exp Pharmacol 175 485 524 10.1007/3-540-29784-7-20 16722247
4. 3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments Neuropharmacology 35 63 70 10.1016/0028-3908(95)00134-4 1:CAS:528:DyaK28XhtlOhsL0%3D 8684598
5. NH Chen ME Reith MW Quick 2004 Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6 Pflügers Arch 447 519 531 10.1007/s00424-003-1064-5 1:CAS:528:DC%2BD2cXhtVygs7o%3D 12719981 (Pubitemid 38241438)
6. IA Cree PE Andreotti 1997 Measurement of cytotoxicity by ATP-based luminescence assay in primary cell cultures and cell lines Toxicol In Vitro 11 553 556 10.1016/S0887-2333(97)00060-X 1:CAS:528:DyaK2sXnvFertL4%3D (Pubitemid 27512701)
7. MW Dudley LL Butcher RC Kammerer AK Cho 1981 The actions of xylamine on central noradrenergic neurons J Pharmacol Exp Ther 217 834 840 1:CAS:528:DyaL3MXkslCmsbY%3D 7230010
8. MW Dudley BD Howard AK Cho 1990 The interaction of the beta-haloethyl benzylamines, xylamine, and DSP-4 with catecholaminergic neurons Annu Rev Pharmacol Toxicol 30 387 403 10.1146/annurev.pa.30.040190.002131 1:CAS:528:DyaK3cXksFekt74%3D 2188573
9. JB Fischer LA Waggaman RW Ransom AK Cho 1983 Xylamine, an irreversible inhibitor of norepinephrine uptake, is transported by this same uptake mechanism in cultured rat superior cervical ganglia J Pharmacol Exp Ther 226 650 655 1:CAS:528:DyaL3sXlvVOjsLw%3D 6887005
10. JM Fritschy R Grzanna 1989 Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals Neuroscience 30 181 197 10.1016/0306-4522(89)90364-3 1:CAS:528: DyaL1MXkvFWrtb8%3D 2747911 (Pubitemid 19159807)
11. B Giros MG Caron 1993 Molecular characterization of the dopamine transporter Trends Pharmacol Sci 14 43 49 10.1016/0165-6147(93)90029-J 1:CAS:528:DyaK3sXisVOks7w%3D 8480373 (Pubitemid 23049339)
12. D Gründemann B Schechinger GA Rappold E Schömig 1998 Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter Nat Neurosci 1 349 351 10.1038/1557 10196521
13. M Hayer-Zillgen M Brüss H Bönisch 2002 Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3 Br J Pharmacol 136 829 836 10.1038/sj.bjp.0704785 1:CAS:528: DC%2BD38XlvV2rurk%3D 12110607 (Pubitemid 34836857)
14. B Hilber P Scholze MM Dorostkar W Sandtner M Holy S Boehm EA Singer HH Sitte 2005 Serotonin-transporter mediated efflux: a pharmacological analysis of amphetamines and non-amphetamines Neuropharmacology 49 811 819 10.1016/j.neuropharm.2005.08.008 1:CAS:528:DC%2BD2MXhtFehsL7M 16185723 (Pubitemid 41483887)
15. BD Howard AK Cho MB Zhang M Koide S Lin 1990 Covalent labeling of the cocaine-sensitive catecholamine transporter J Neurosci Res 26 149 158 10.1002/jnr.490260204 1:CAS:528:DyaK3cXkslWlu70%3D 2142222 (Pubitemid 20197819)
16. G Jonsson H Hallman F Ponzio S Ross 1981 DSP4 (N-(2-chloroethyl)-N-ethyl- 2-bromobenzylamine)-a useful denervation tool for central and peripheral noradrenaline neurons Eur J Pharmacol 72 173 188 10.1016/0014-2999(81)90272-7 1:CAS:528:DyaL3MXkslCmuro%3D 6265244 (Pubitemid 11072495)
17. H Koepsell K Lips C Volk 2007 Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications Pharm Res 24 1227 1251 10.1007/s11095-007-9254-z 1:CAS:528:DC%2BD2sXnt1Clu7Y%3D 17473959 (Pubitemid 46876495)
18. M Koide AK Cho SD Howard 1986 Characterization of xylamine binding to proteins of PC12 pheochromocytoma cells J Neurochem 47 1277 1285 1:CAS:528:DyaL28XlvVClsr4%3D 3746302
19. ME Landa MC Rubio G Jaim-Etcheverry 1987 The aziridinium derivative of DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) accelerates the beating rate of isolated rat atria by enhancing the spontaneous release of noradrenaline Naunyn-Schmiedebergs Arch Pharmacol 336 396 402 10.1007/BF00164872 1:CAS:528:DyaL1cXltVOrsg%3D%3D 3431596 (Pubitemid 18008968)
20. OH Lowry NJ Rosenbrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
21. JD Park KJ Lee DH Kim 2001 A new inhibitor design strategy for carboxypeptidase A as exemplified by N-(2-chloroethyl)-N-methylphenylalanine Bioorg Med Chem 9 237 243 10.1016/S0968-0896(00)00239-X 1:CAS:528: DC%2BD3MXhs1artLk%3D 11249116 (Pubitemid 32244023)
22. C Pifl B Giros MG Caron 1993 Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium J Neurosci 13 4246 4253 1:CAS:528: DyaK2cXkslGnuw%3D%3D 8410185
23. RW Ransom RC Kammerer AK Cho 1982 Chemical transformations of xylamine (N-2'-chloroethyl-N-ethyl-2-methylbenzylamine) in solution. Pharmacological activity of the species derived from this irreversible norepinephrine uptake inhibitor Mol Pharmacol 21 380 386 1:CAS:528:DyaL38Xktlejt7g%3D 7099142
24. RW Ransom LA Waggaman AK Cho 1985 Interaction of xylamine with peripheral sympathetic neurons Life Sci 37 1177 1182 10.1016/0024-3205(85)90128-6 1:CAS:528:DyaL2MXltlGis7k%3D 3930904 (Pubitemid 16243141)
25. SB Ross AL Renyl 1976 On the long-lasting inhibitory effect of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP 4) on the active uptake of noradrenaline J Pharm Pharmacol 28 458 459 1:CAS:528:DyaE28XkslaitL0%3D 6763
26. G Rudnick 2006 Serotonin transporters-structure and function J Membr Biol 213 101 110 10.1007/s00232-006-0878-4 1:CAS:528:DC%2BD2sXktlWis7s%3D 17417703 (Pubitemid 46626129)
27. E Schömig A Lazar D Gründemann 2006 Extraneuronal monoamine transporter and organic cation transporters 1 and 2: a review of transport efficiency Handb Exp Pharmacol 175 151 180 10.1007/3-540-29784-7-8 16722235
28. SA Waterman CF Harding 2008 Neurotoxic effects of DSP-4 on the central noradrenergic system in male zebra finches Behav Brain Res 188 271 280 10.1016/j.bbr.2007.11.004 1:CAS:528:DC%2BD1cXhslOjtb0%3D 18160108
29. B Wenge H Bönisch 2008 N-Ethylmaleimide differentially inhibits substrate uptake by and ligand binding to the noradrenaline transporter Naunyn-Schmiedebergs Arch Pharmacol 377 255 265 10.1007/s00210-008-0272-0 1:CAS:528:DC%2BD1cXkvVSitbo%3D 18357440