Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years

Neurobiology of Aging

Volumn 31, Issue 2, 2010, Pages 215-223

  Stomrud, Erik ^a   Hansson, Oskar ^a   Minthon, Lennart ^a   Blennow, Kaj ^b   Rosén, Ingmar ^c   Londos, Elisabet ^a  

^a LUND UNIVERSITY   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Alzheimer disease; Amyloid beta protein; AQT; Biological markers; Cerebrospinal fluid; Cognition; Control group; Dementia; Early diagnosis; Electroencephalography; Mild cognitive impairment; Tau protein; Theta rhythm

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; TAU PROTEIN;

AGED; AGING; ALPHA RHYTHM; ARTICLE; BETA RHYTHM; BIOCHEMISTRY; BRAIN FUNCTION; CEREBROSPINAL FLUID ANALYSIS; COGNITION; CONTROLLED STUDY; DELTA RHYTHM; ELECTROENCEPHALOGRAPHY; FEMALE; FREQUENCY ANALYSIS; HUMAN; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; SCORING SYSTEM; THETA RHYTHM;

AGED; AMYLOID BETA-PROTEIN; APOLIPOPROTEIN E4; BIOLOGICAL MARKERS; BRAIN; COGNITION; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; REGRESSION ANALYSIS; SPINAL PUNCTURE; TAU PROTEINS; THETA RHYTHM; TIME FACTORS;

EID: 71349085112     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.03.025     Document Type: Article

References (58)

1. Babiloni C., Binetti G., Cassetta E., Dal Forno G., Del Percio C., Ferreri F., Ferri R., Frisoni G., Hirata K., Lanuzza B., Miniussi C., Moretti D.V., Nobili F., Rodriguez G., Romani G.L., Salinari S., and Rossini P.M. Sources of cortical rhythms change as a function of cognitive impairment in pathological aging: a multicenter study. Clin. Neurophysiol. 117 2 (2006) 252-268
2. Backman L., Jones S., Berger A.K., Laukka E.J., and Small B.J. Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis. Neuropsychology 19 4 (2005) 520-531
3. Blennow K. CSF biomarkers for mild cognitive impairment. J. Intern. Med. 256 3 (2004) 224-234
4. Blennow K., de Leon M.J., and Zetterberg H. Alzheimer's disease. Lancet 368 9533 (2006) 387-403
5. Blennow K., Zetterberg H., Minthon L., Lannfelt L., Strid S., Annas P., Basun H., and Andreasen N. Longitudinal stability of CSF biomarkers in Alzheimer's disease. Neurosci. Lett. 419 1 (2007) 18-22
6. Braak E., Griffing K., Arai K., Bohl J., Bratzke H., and Braak H. Neuropathology of Alzheimer's disease: what is new since A. Alzheimer?. Eur. Arch. Psychiatry Clin. Neurosci. 249 Suppl. 3 (1999) 14-22
7. Brassen S., and Adler G. Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial. Pharmacopsychiatry 36 6 (2003) 304-308
8. Brys M., Pirraglia E., Rich K., Rolstad S., Mosconi L., Switalski R., Glodzik-Sobanska L., De Santi S., Zinkowski R., Mehta P., Pratico D., Saint Louis L.A., Wallin A., Blennow K., and de Leon M.J. Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment. Neurobiol. Aging (2007) in press
9. Buerger K., Ewers M., Pirttila T., Zinkowski R., Alafuzoff I., Teipel S.J., DeBernardis J., Kerkman D., McCulloch C., Soininen H., and Hampel H. CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease. Brain 129 Pt 11 (2006) 3035-3041
10. Chapman C.A., and Lacaille J.C. Cholinergic induction of theta-frequency oscillations in hippocampal inhibitory interneurons and pacing of pyramidal cell firing. J. Neurosci. 19 19 (1999) 8637-8645
11. Coben L.A., Danziger W., and Storandt M. A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years. Electroencephalogr. Clin. Neurophysiol. 61 2 (1985) 101-112
12. de Leon M.J., DeSanti S., Zinkowski R., Mehta P.D., Pratico D., Segal S., Clark C., Kerkman D., DeBernardis J., Li J., Lair L., Reisberg B., Tsui W., and Rusinek H. MRI and CSF studies in the early diagnosis of Alzheimer's disease. J. Intern. Med. 256 3 (2004) 205-223
13. de Leon M.J., DeSanti S., Zinkowski R., Mehta P.D., Pratico D., Segal S., Rusinek H., Li J., Tsui W., Saint Louis L.A., Clark C.M., Tarshish C., Li Y., Lair L., Javier E., Rich K., Lesbre P., Mosconi L., Reisberg B., Sadowski M., DeBernadis J.F., Kerkman D.J., Hampel H., Wahlund L.O., and Davies P. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol. Aging 27 3 (2006) 394-401
14. de Leon M.J., Mosconi L., Blennow K., DeSanti S., Zinkowski R., Mehta P.D., Pratico D., Tsui W., Saint Louis L.A., Sobanska L., Brys M., Li Y., Rich K., Rinne J., and Rusinek H. Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease. Ann. N. Y. Acad. Sci. 1097 (2007) 114-145
15. Dubois B., Feldman H.H., Jacova C., Dekosky S.T., Barberger-Gateau P., Cummings J., Delacourte A., Galasko D., Gauthier S., Jicha G., Meguro K., O'Brien J., Pasquier F., Robert P., Rossor M., Salloway S., Stern Y., Visser P.J., and Scheltens P. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet. Neurol. 6 8 (2007) 734-746
16. Elmstahl S., Rosen I., and Gullberg B. Quantitative EEG in elderly patients with Alzheimer's disease and healthy controls. Dementia 5 2 (1994) 119-124
17. Fagan A.M., Roe C.M., Xiong C., Mintun M.A., Morris J.C., and Holtzman D.M. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch. Neurol. 64 3 (2007) 343-349
18. Folstein M.F., Folstein S.E., and McHugh P.R. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 3 (1975) 189-198
19. Gauthier S., Reisberg B., Zaudig M., Petersen R.C., Ritchie K., Broich K., Belleville S., Brodaty H., Bennett D., Chertkow H., Cummings J.L., de Leon M., Feldman H., Ganguli M., Hampel H., Scheltens P., Tierney M.C., Whitehouse P., and Winblad B. Mild cognitive impairment. Lancet 367 9518 (2006) 1262-1270
20. Gawel M., Zalewska E., Szmidt-Salkowska E., and Kowalski J. Does EEG (visual and quantitative) reflect mental impairment in subcortical vascular dementia?. J. Neurol. Sci. 257 1/2 (2007) 11-16
21. Grunwald M., Hensel A., Wolf H., Weiss T., and Gertz H.J. Does the hippocampal atrophy correlate with the cortical theta power in elderly subjects with a range of cognitive impairment?. J. Clin. Neurophysiol. 24 1 (2007) 22-26
22. Gustafson D.R., Skoog I., Rosengren L., Zetterberg H., and Blennow K. Cerebrospinal fluid beta-amyloid 1-42 concentration may predict cognitive decline in older women. J. Neurol. Neurosurg. Psychiatry 78 5 (2007) 461-464
23. Hansson O., Zetterberg H., Buchhave P., Londos E., Blennow K., and Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 5 3 (2006) 228-234
24. Hesse C., Rosengren L., Andreasen N., Davidsson P., Vanderstichele H., Vanmechelen E., and Blennow K. Transient increase in total tau but not phospho-tau in human cerebrospinal fluid after acute stroke. Neurosci. Lett. 297 3 (2001) 187-190
25. Huey E.D., Mirza N., Putnam K.T., Soares H., Csako G., Levy J.A., Copenhaver B., Cohen R.M., and Sunderland T. Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients. Dement. Geriatr. Cogn. Disord. 22 1 (2006) 48-53
26. Itoh N., Arai H., Urakami K., Ishiguro K., Ohno H., Hampel H., Buerger K., Wiltfang J., Otto M., Kretzschmar H., Moeller H.J., Imagawa M., Kohno H., Nakashima K., Kuzuhara S., Sasaki H., and Imahori K. Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease. Ann. Neurol. 50 2 (2001) 150-156
27. Jacobson J.M., Nielsen N.P., Minthon L., Warkentin S., and Wiig E.H. Multiple rapid automatic naming measures of cognition: normal performance and effects of aging. Percept. Mot. Skills 98 3 (Pt 1) (2004) 739-753
28. Jelic V., Blomberg M., Dierks T., Basun H., Shigeta M., Julin P., Jensen M., Lannfelt L., Winblad B., and Wahlund L.O. EEG slowing and cerebrospinal fluid tau levels in patients with cognitive decline. Neuroreport 9 1 (1998) 157-160
29. Jelic V., Johansson S.E., Almkvist O., Shigeta M., Julin P., Nordberg A., Winblad B., and Wahlund L.O. Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer's disease. Neurobiol. Aging 21 4 (2000) 533-540
30. Jeong J. EEG dynamics in patients with Alzheimer's disease. Clin. Neurophysiol. 115 7 (2004) 1490-1505
31. Kogan E.A., Korczyn A.D., Virchovsky R.G., Klimovizky S., Treves T.A., and Neufeld M.Y. EEG changes during long-term treatment with donepezil in Alzheimer's disease patients. J. Neural. Transm. 108 10 (2001) 1167-1173
32. Kwak Y.T. Quantitative EEG findings in different stages of Alzheimer's disease. J. Clin. Neurophysiol. 23 5 (2006) 456-461
33. Lehmann C., Koenig T., Jelic V., Prichep L., John R.E., Wahlund L.O., Dodge Y., and Dierks T. Application and comparison of classification algorithms for recognition of Alzheimer's disease in electrical brain activity (EEG). J. Neurosci. Methods 161 2 (2007) 342-350
34. Leuchter A.F., Cook I.A., Newton T.F., Dunkin J., Walter D.O., Rosenberg-Thompson S., Lachenbruch P.A., and Weiner H. Regional differences in brain electrical activity in dementia: use of spectral power and spectral ratio measures. Electroencephalogr. Clin. Neurophysiol. 87 6 (1993) 385-393
35. Lopes da Silva F. Neural mechanisms underlying brain waves: from neural membranes to networks. Electroencephalogr. Clin. Neurophysiol. 79 2 (1991) 81-93
36. Mattia D., Babiloni F., Romigi A., Cincotti F., Bianchi L., Sperli F., Placidi F., Bozzao A., Giacomini P., Floris R., and Grazia Marciani M. Quantitative EEG and dynamic susceptibility contrast MRI in Alzheimer's disease: a correlative study. Clin. Neurophysiol. 114 7 (2003) 1210-1216
37. McKhann G., Drachman D., Folstein M., Katzman R., Price D., and Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34 7 (1984) 939-944
38. Olsson A., Vanderstichele H., Andreasen N., De Meyer G., Wallin A., Holmberg B., Rosengren L., Vanmechelen E., and Blennow K. Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology. Clin. Chem. 51 2 (2005) 336-345
39. Onishi J., Suzuki Y., Yoshiko K., Hibino S., and Iguchi A. Predictive model for assessing cognitive impairment by quantitative electroencephalography. Cogn. Behav. Neurol. 18 3 (2005) 179-184
40. Osipova D., Ahveninen J., Kaakkola S., Jaaskelainen I.P., Huttunen J., and Pekkonen E. Effects of scopolamine on MEG spectral power and coherence in elderly subjects. Clin. Neurophysiol. 114 10 (2003) 1902-1907
41. Petersen R.C., Stevens J.C., Ganguli M., Tangalos E.G., Cummings J.L., and DeKosky S.T. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review) report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56 9 (2001) 1133-1142
42. Price J.L., and Morris J.C. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann. Neurol. 45 3 (1999) 358-368
43. Prichep L.S., John E.R., Ferris S.H., Rausch L., Fang Z., Cancro R., Torossian C., and Reisberg B. Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging. Neurobiol. Aging 27 3 (2006) 471-481
44. Prichep L.S., John E.R., Ferris S.H., Reisberg B., Almas M., Alper K., and Cancro R. Quantitative EEG correlates of cognitive deterioration in the elderly. Neurobiol. Aging 15 1 (1994) 85-90
45. Rae-Grant A., Blume W., Lau C., Hachinski V.C., Fisman M., and Merskey H. The electroencephalogram in Alzheimer-type dementia. A sequential study correlating the electroencephalogram with psychometric and quantitative pathologic data. Arch. Neurol. 44 1 (1987) 50-54
46. Rodriguez G., Nobili F., Rocca G., De Carli F., Gianelli M.V., and Rosadini G. Quantitative electroencephalography and regional cerebral blood flow: discriminant analysis between Alzheimer's patients and healthy controls. Dement. Geriatr. Cogn. Disord. 9 5 (1998) 274-283
47. Rosen W.G., Mohs R.C., and Davis K.L. A new rating scale for Alzheimer's disease. Am. J. Psychiatry 141 11 (1984) 1356-1364
48. Rossini P.M., Del Percio C., Pasqualetti P., Cassetta E., Binetti G., Dal Forno G., Ferreri F., Frisoni G., Chiovenda P., Miniussi C., Parisi L., Tombini M., Vecchio F., and Babiloni C. Conversion from mild cognitive impairment to Alzheimer's disease is predicted by sources and coherence of brain electroencephalography rhythms. Neuroscience 143 3 (2006) 793-803
49. Rossini P.M., Rossi S., Babiloni C., and Polich J. Clinical neurophysiology of aging brain: from normal aging to neurodegeneration. Prog. Neurobiol. 83 6 (2007) 375-400
50. Schoonenboom N.S., van der Flier W.M., Blankenstein M.A., Bouwman F.H., Van Kamp G.J., Barkhof F., and Scheltens P. CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease. Neurobiol. Aging 29 5 (2008) 669-675
51. Siok C.J., Rogers J.A., Kocsis B., and Hajos M. Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation. Eur. J. Neurosci. 23 2 (2006) 570-574
52. Sjogren M., Davidsson P., Tullberg M., Minthon L., Wallin A., Wikkelso C., Granerus A.K., Vanderstichele H., Vanmechelen E., and Blennow K. Both total and phosphorylated tau are increased in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 70 5 (2001) 624-630
53. Skoog I., Davidsson P., Aevarsson O., Vanderstichele H., Vanmechelen E., and Blennow K. Cerebrospinal fluid beta-amyloid 42 is reduced before the onset of sporadic dementia: a population-based study in 85-year-olds. Dement. Geriatr. Cogn. Disord. 15 3 (2003) 169-176
54. Soininen H., Reinikainen K.J., Partanen J., Helkala E.L., Paljarvi L., and Riekkinen P.J. Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer's disease. Neuroscience 49 3 (1992) 529-535
55. Stomrud E., Hansson O., Blennow K., Minthon L., and Londos E. Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly. Dement. Geriatr. Cogn. Disord. 24 2 (2007) 118-124
56. Tapiola T., Pirttila T., Mikkonen M., Mehta P.D., Alafuzoff I., Koivisto K., and Soininen H. Three-year follow-up of cerebrospinal fluid tau, beta-amyloid 42 and 40 concentrations in Alzheimer's disease. Neurosci. Lett. 280 2 (2000) 119-122
57. van der Hiele K., Vein A.A., van der Welle A., van der Grond J., Westendorp R.G., Bollen E.L., van Buchem M.A., van Dijk J.G., and Middelkoop H.A. EEG and MRI correlates of mild cognitive impairment and Alzheimer's disease. Neurobiol. Aging 28 9 (2007) 1322-1329
58. Wiig E.H., Nielsen N.P., Minthon L., McPeek D., Said K., and Warkentin S. Parietal lobe activation in rapid, automatized naming by adults. Percept. Mot. Skills 94 3 Pt 2 (2002) 1230-1244