A single nucleotide mutation results in loss of enzymatic activity in the hyaluronate lyase gene of Streptococcus pyogenes

Microbial Pathogenesis

Volumn 47, Issue 6, 2009, Pages 308-313

  Hynes, Wayne ^a   Johnson, Cecelia ^a   Stokes, Martha ^a  

^a OLD DOMINION UNIVERSITY   (United States)

Author keywords

Anti virulence factor; Hyaluronate lyase; Streptococcus pyogenes; Virulence

Indexed keywords

ASPARTIC ACID; BACTERIAL ENZYME; HYALURONATE LYASE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL VIRULENCE; CONTROLLED STUDY; ENZYME INACTIVATION; GENOTYPE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS PYOGENES;

AMINO ACID SEQUENCE; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MUTAGENESIS, SITE-DIRECTED; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYSACCHARIDE-LYASES; SEQUENCE ALIGNMENT; STREPTOCOCCUS PYOGENES;

BACTERIA (MICROORGANISMS); HYLA; STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SP. 'GROUP A';

EID: 71249153709     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2009.09.008     Document Type: Article

References (27)

1. Gabbay V., Coffey B.J., Babb J.S., Meyer L., Wachtel C., Anam S., et al. Pediatric autoimmune neuropsychiatric disorders associated with streptococcus: comparison of diagnosis and treatment in the community and at a specialty clinic. Pediatrics 122 (2008) 273-278
2. Carapetis J.R., Steer A.C., Mulholland E.K., and Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis 5 (2005) 685-694
3. Hynes W. Virulence factors of the group A streptococci and genes that regulate their expression. Front Biosci 9 (2004) 3399-3433
4. Linhardt R.J., Galliher P.M., and Cooney C.L. Polysaccharide lyases. Appl Biochem Biotechnol 12 (1986) 135-176
5. Hynes W.L., Dixon A.R., Walton S., and Aridgides L.J. The extracellular hyaluronidase gene (hylA) of Streptococcus pyogenes. FEMS Microbiol Lett 184 (2000) 109-112
6. Starr C.R., and Engleberg N.C. Role of hyaluronidase in subcutaneous spread and growth of group A streptococcus. Infect Immun 74 (2006) 40-48
7. Walton S. Hyaluronate lyase gene of Streptococcus pyogenes; molecular characterization and regulation. Ph.D. dissertation. Norfolk: Old Dominion University; 2003.
8. Kreikemeyer B., McIver K.S., and Podbielski A. Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions. Trends Microbiol 11 (2003) 224-232
9. Musser J.M., and DeLeo F.R. Toward a genome-wide systems biology analysis of host-pathogen interactions in group A Streptococcus. Am J Pathol 167 (2005) 1461-1472
10. Stokes M. Serotype association and regulation of the hyaluronate lyase gene of Streptococcus pyogenes. PhD dissertation. Norfolk: Old Dominion University; 2007.
11. Jedrzejas I.J., and Chantalat L. Structural studies of Streptococcus agalactiae hyaluronate lyase. Acta Cryst 56 (2000) 460-463
12. Jedrzejas M.J., Chantalat L., and Mewbourne R.B. Crystallization and preliminary X-ray analysis of Streptococcus pneumoniae hyaluronate lyase. J Struct Biol 121 (1998) 73-75
13. Akhtar M.S., and Bhakuni V. Role of ionic interactions and linker in the domain interaction and modulation of functional activity of hyaluronate lyases. Biochem Biophys Res Commun 353 (2007) 286-292
14. Li S., and Jedrzejas M.J. Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. J Biol Chem 276 (2001) 41407-41416
15. Ponnuraj K., and Jedrzejas M.J. Mechanism of hyaluronan binding and degradation: structure of Streptococcus pneumoniae hyaluronate lyase in complex with hyaluronic acid disaccharide at 1.7 A resolution. J Mol Biol 299 (2000) 885-895
16. Pritchard D.G., Trent J.O., Li X., Zhang P., Egan M.L., and Baker J.R. Characterization of the active site of group B streptococcal hyaluronan lyase. Proteins 40 (2000) 675
17. Jedrzejas M.J., Mello L.V., de Groot B.L., and Li S. Mechanism of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase. Structures of complexes with the substrate. J Biol Chem 277 (2002) 28287-28297
18. Pritchard D.G., Trent J.O., Li X., Zhang P., Egan M.L., and Baker J.R. Characterization of the active site of group B streptococcal hyaluronan lyase. Proteins 40 (2000) 126-134
19. Aziz R.K., Edwards R.A., Taylor W.W., Low D.E., McGeer A., and Kotb M. Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes. J Bacteriol 187 (2005) 3311-3318
20. Banks D.J., Beres S.B., and Musser J.M. The fundamental contribution of phages to GAS evolution, genome diversification and strain emergence. Trends Microbiol 10 (2002) 515-521
21. Creti R., Imperi M., Baldassarri L., Pataracchia M., Recchia S., Alfarone G., et al. Emm Types, virulence factors, and antibiotic resistance of invasive Streptococcus pyogenes isolates from Italy: what has changed in 11 years?. J Clin Microbiol 45 (2007) 2249-2256
22. Doktor S.Z., Beyer J.M., Flamm R.K., and Shortridge V.D. Comparison of emm typing and ribotyping with three restriction enzymes to characterize clinical isolates of Streptococcus pyogenes. J Clin Microbiol 43 (2005) 150-155
23. Ekelund K., Skinhoj P., Madsen J., and Konradsen H.B. Reemergence of emm1 and a changed super antigen profile for group A streptococci causing invasive infections: results from a nationwide study. J Clin Microbiol 43 (2005) 1789-1796
24. McGregor K.F., Spratt B.G., Kalia A., Bennett A., Bilek N., Beall B., et al. Multilocus sequence typing of Streptococcus pyogenes representing most known emm types and distinctions among subpopulation genetic structures. J Bacteriol 186 (2004) 4285-4294
25. Sakota V., Fry A.M., Lietman T.M., Facklam R.R., Li Z., and Beall B. Genetically diverse group A streptococci from children in far-western Nepal share high genetic relatedness with isolates from other countries. J Clin Microbiol 44 (2006) 2160-2166
26. Shulman S.T., Tanz R.R., Kabat W., Kabat K., Cederlund E., Patel D., et al. Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002. Clin Infect Dis 39 (2004) 325-332
27. Hynes W.L., and Ferretti J.J. Sequence analysis and expression in Escherichia coli of the hyaluronidase gene of Streptococcus pyogenes bacteriophage H4489A. Infect Immun 57 (1989) 533-539