Strain development of Streptomyces sp. for tacrolimus production using sequential adaptation

Journal of Industrial Microbiology and Biotechnology

Volumn 36, Issue 12, 2009, Pages 1467-1471

  Jung, Sangwon ^a,b   Moon, Sunghyun ^b   Lee, Kyungsun ^b   Park, Youn Je ^b   Yoon, Sewang ^b   Yoo, Young Je ^a  

^a Seoul National University   (South Korea)

^b TS Corporation   (South Korea)

Author keywords

Fermentation; Product inhibition; S. tsukubaensis; Sequential adaptation; Strain development; Tacrolimus

Indexed keywords

TACROLIMUS;

ADAPTATION; ARTICLE; BACTERIAL STRAIN; BIOREACTOR; DRUG MANUFACTURE; NONHUMAN; SEQUENTIAL ANALYSIS; STREPTOMYCES;

ADAPTATION, PHYSIOLOGICAL; CULTURE MEDIA; DRUG RESISTANCE, BACTERIAL; FERMENTATION; IMMUNOSUPPRESSIVE AGENTS; INDUSTRIAL MICROBIOLOGY; KOREA; MICROBIAL SENSITIVITY TESTS; STREPTOMYCES; TACROLIMUS;

STREPTOMYCES SP.;

EID: 71249150385     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-009-0634-8     Document Type: Article

References (14)

1. T Kino H Hatanaka M Hashimoto M Nishiyama T Goto M Okuhara M Kohsaka H Aoki H Imanaka 1987 FK-506, a novel immunosuppressant isolated from a Streptomyces: I. fermentation, isolation, and physico-chemical and biological characteristics J Antibiot 40 1249 1255 1:CAS:528:DyaL2sXmt1ylurc%3D 2445721
2. T Kino H Hatanaka S Miyata N Imaura M Nishiyama T Yakima T Goto M Okuhara M Kohsaka H Aoki T Ochiai 1987 FK-506, a novel immunosuppressant isolated from a Streptomyces: II. immunosuppressive effect of FK-506 in vitro J Antibiot 40 1256 1265 1:CAS:528:DyaL2sXmtFWmu7g%3D 2445722 (Pubitemid 17138110)
3. Med Ad News (2008) 200 World's best-selling medicine. Med Ad News 27: 12-33
4. H Kim Y Park 2008 Isolation and identification of a novel microorganism producing the immunosuppressant Tacrolimus J Biosci Bioeng 105 418 421 10.1263/jbb.105.418 1:CAS:528:DC%2BD1cXnslajurw%3D 18499061 (Pubitemid 351680742)
5. H Kim Y Park 2007 Lipase activity and Tacrolimus production in Streptomyces clavuligerus CKD 1119 mutant strains J Microbiol Biotechnol 17 1638 1644 1:CAS:528:DC%2BD2sXhtlOlt7jM 18156779
6. Kumar P, Malviya HK, Maurya RK, Shukla A (2007) Fermentation processes for the preparation of tacrolimus. International publication patent no. WO 2007/039816 A2
7. Vaid S, Narula P (2006) Novel process for producing tacrolimus (FK-506) using vegetable oil as sole source of carbon. International publication patent no. WO 2006/011156 A2
8. GM Garrity BK Heimbuch H Motamedi A Shafiee 1993 Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and rapamycin J Ind Microbiol 12 42 47 10.1007/BF01570127 1:CAS:528:DyaK2cXktVCrtb0%3D 7688970
9. LE Khaw GA Bohm S Metcalfe J Staunton PF Leadlay 1998 Mutational biosynthesis of novel rapamycin by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase J Bacteriol 180 809 814 1:CAS:528:DyaK1cXhtVGls7k%3D 9473033
10. H Motamedi A Shafiee S Cai SL Streicher BH Arison RR Miller 1996 Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520 J Bacteriol 178 5243 5248 1:CAS:528:DyaK28Xltlartrs%3D 8752344
11. H Motamedi A Shafiee 1998 The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506 Eur J Biochem 256 528 534 10.1046/j.1432-1327.1998.2560528.x 1:CAS:528:DyaK1cXmtlCgtbg%3D 9780228 (Pubitemid 28440418)
12. Lee HH (2003) Enhanced production of immunosuppressant FK-506 by Streptomyces sp. in a defined medium by release from the regulation of ammonium ion. Seoul National University, Seoul
13. YJ Yoon CY Choi 1997 Nutrient effects on FK-506, a new immunosuppressant, production by Streptomyces sp. in a defined medium J Ferment Bioeng 83 599 603 10.1016/S0922-338X(97)81145-2 1:CAS:528:DyaK2sXksFWku7o%3D (Pubitemid 27311311)
14. WP Weizheng E Kusters O Lohse CP Mak Y Wang 1999 Application of centrifugal counter-current chromatography to the separation of macrolide antibiotic analogues: I. selection of solvent systems based on solubility and partition coefficient investigations J Chromatogr A 864 69 76 10.1016/S0021-9673(99)01012-2