Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis

British Journal of Pharmacology

Volumn 158, Issue 7, 2009, Pages 1777-1786

  Campia, I ^a   Lussiana, C ^a   Pescarmona, G ^a,b   Ghigo, D ^a,b   Bosia, A ^a,b   Riganti, C ^a,b  

^a Department of Genetics Biology and Biochemistry ^*  (Italy)

^b Research Center for Experimental Medicine (CeRMS)   (Italy)

Author keywords

Cholesterol; G proteins; Geranylgeraniol; Statins; Ubiquinone

Indexed keywords

CHOLESTEROL; COMPACTIN; GERANYLGERANIOL; GERANYLGERANYL PYROPHOSPHATE; ISOPRENOID; MEVALONIC ACID; RAC PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; UBIQUINONE;

ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL PROTECTION; CHOLESTEROL SYNTHESIS; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LIVER CELL; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; MONOCYTIC LEUKEMIA; PRIORITY JOURNAL;

CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CHOLESTEROL; DITERPENES; ELECTRON TRANSPORT; HEP G2 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MITOCHONDRIA; MONOCYTES; TERPENES; UBIQUINONE;

EID: 71249130470     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00465.x     Document Type: Article

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