Effect of cytostatic drugs on the sludge and on the mixed liquor characteristics of a cross-flow membrane bioreactor: Consequence on the process

Journal of Membrane Science

Volumn 347, Issue 1-2, 2010, Pages 165-173

  Delgado, Luis F ^a   Faucet Marquis, Virginie ^a   Schetrite, Sylvie ^a   Pfohl Leszkowicz, Annie ^a   Paranthoen, Sylvia ^b   Albasi, Claire ^a  

^a LABORATOIRE DE GÉNIE CHIMIQUE   (France)

^b PALL EXEKIA   (France)

Author keywords

Anticancer drug; Cyclophosphamide; Extracellular polymeric substances; Membrane bioreactor; Membrane fouling; Micropollutants

Indexed keywords

ACTIVATED SLUDGE; ANTICANCER DRUG; BIOLOGICAL MATRIXES; BIOLOGICAL TREATMENT; CONCENTRATION OF; CROSSFLOW MEMBRANES; CROSSFLOW VELOCITIES; ENDOGENOUS RESPIRATION; EXTRA-CELLULAR POLYMERIC SUBSTANCES; FOULING POTENTIAL; HUMIC SUBSTANCES; MEMBRANE BIOREACTOR; MEMBRANE PERFORMANCE; MICROPOLLUTANTS; OPERATING CONDITION; PERMEATE QUALITY; PHYSICOCHEMICAL PROPERTY; RUNNING-IN; SMALL PARTICLES; SPECIFIC CAKE RESISTANCES;

BIOCHEMICAL ENGINEERING; BIOCONVERSION; BIOPOLYMERS; BIOREACTORS; EFFLUENT TREATMENT; MEMBRANE FOULING; MICROORGANISMS; POLYMERS; WASTEWATER TREATMENT;

MEMBRANES;

4 OXOCYCLOPHOSPHAMIDE; CYCLOPHOSPHAMIDE; POLYSACCHARIDE;

ACTIVATED SLUDGE; ARTICLE; BIOFOULING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSSFLOW FILTRATION; FILTER CAKE; MEMBRANE FILTER; MEMBRANE PERMEABILITY; MEMBRANE REACTOR; MICROBIAL RESPIRATION; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; WASTE WATER MANAGEMENT;

EID: 71249123916     PISSN: 03767388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.memsci.2009.10.020     Document Type: Article

References (51)

1. Buerge I.J., Buser H.R., Poiger T., and Müller M.D. Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters. Environ. Sci. Technol. 40 (2006) 7242-7250
2. Johnson A.C., Jürgens M.D., Williams R.J., Kümmerer K., Kortenkamp A., and Sumpter J.P. Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study. J. Hydrol. 348 (2008) 167-175
3. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources-a review. Chemosphere 45 (2001) 957-969
4. Lenz K., Hann S., Koellensperger G., Stefánka Z., Stingeder G., Weissenbacher N., Mahnik S.N., and Fuerhacker M. Presence of cancerostatic platinum compounds in hospital wastewater and possible elimination by adsorption to activated sludge. Sci. Total Environ. 345 (2005) 141-152
5. Lenz K., Koellensperger G., Hann S., Weissenbacher N., Mahnik S.N., and Fuerhacker M. Fate of cancerostatic platinum compounds in biological wastewater treatment of hospital effluents. Chemosphere 69 (2007) 1765-1774
6. Mahnik S.N., Lenz K., Weissenbacher N., Mader R.M., and Fuerhacker M. Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system. Chemosphere 66 (2007) 30-37
7. Steger-Hartmann T., Kümmerer K., and Hartmann A. Biological degradation of cyclophosphamide and its occurrence in sewage water. Ecotoxicol. Environ. Saf. 36 (1997) 174-179
8. Huitema Alwin D.R., Reinders C., Tibben Matthijs M., Rodenhuis S., and Beijnen H.J. Sensitive gas chromatographic determination of the cyclophosphamide metabolite 2-dechloroethylcyclophosphamide in human plasma. J. Chromatogr. B 757 (2001) 349-357
9. Moore M.J. Clinical pharmacokinetics of cyclophosphamide. Clin. Pharmacokinet. 20 (1991) 1994-2008
10. Sladek N.E. Metabolism and pharmacokinetic behavior of cyclophosphamide and related oxazaphosphorines. In: Powis G. (Ed). Anticancer Drugs: Reactive Metabolism and Drug Interactions. (1994), Pergamon Press, Oxford, UK 79-156
11. Joqueviel C., Martino R., Gilard V., Malet-Martino M., Canal P., and Niemeyer U. Urinary excretion of cyclophosphamide in humans, determined by phosphorus-31 nuclear magnetic resonante spectroscopy. Drug Metab. Dispos. 26 5 (1998) 418-428
12. Clara M., Strenn B., Gans O., Martinez E., Kreuzinger N., and Kroiss H. Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Res. 39 (2005) 4797-4807
13. De Wever H., Weiss S., Reemtsma T., Vereecken J., Müller J., Knepper T., Röden O., Gonzalez S., Barcelo D., and Hernando M.D. Comparison of sulfonated and other micropollutants removal in membrane bioreactor and conventional wastewater treatment. Water Res. 41 (2007) 935-945
14. Bernhard M., Müller J., and Knepper T.P. Biodegradation of persistent polar pollutants in wastewater: comparison of an optimised lab-scale membrane bioreactor and activated sludge treatment. Water Res. 40 (2006) 3419-3428
15. Quintana J., Weiss S., and Reemtsma T. Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res. 39 (2005) 1664-2654
16. Weiss S., and Reemtsma T. Membrane bioreactors for municipal wastewater treatment-a viable option to reduce the amount of polar pollutants discharged into surface waters?. Water Res. 42 (2008) 3837-3847
17. Judd S.J. A review of fouling of membrane bioreactors in sewage treatment. Water Sci. Technol. 49 2 (2004) 229-235
18. Rosenberger S., and Kraume M. Filterability of activated sludge in membrane bioreactors. Desalination 146 (2002) 373-379
19. Hernandez Rojas M.E., Van Kaam R., Schetrite S., and Albasi C. Role and variation of supernatant compounds in submerged membrane bioreactor fouling. Desalination 179 (2005) 95-107
20. Nuengjamnong Ch., Kweon J.H., Cho J., Polprasert Ch., and Ahn K.H. Membrane fouling caused by extracellular polymeric substances during microfiltration processes. Desalination 179 (2005) 117-124
21. Bae T.H., and Tank T.M. Interpretation of fouling characteristics of ultrafiltration membranes during the filtration of membrane bioreactor mixed liquor. J. Membr. Sci. 264 (2005) 151-160
22. Le-Clech P., Chen V., and Fane T.A.G. Fouling in membrane bioreactors used in wastewater treatment. J. Membr. Sci. 284 (2006) 17-53
23. Rosenberger S., Laabs C., Lesjean B., Gnirss R., Amy G., Jekel M., and Schrotter J.C. Impact of colloidal and soluble performance in membrane bioreactor for municipal wastewater treatment. Water Res. 40 (2006) 710
24. Rosenberger S., Evenblij H., te Poele S., Wintgens T., and Laabs C. The importance of liquid phase analyses to understand fouling in membrane assisted activated sludge processes-six case studies of different European research groups. J. Membr. Sci. 263 (2005) 113-126
25. Meng F., Zhang H., Yang F., Zhang S., Li Y., and Zhang X. Identification of activated sludge properties affecting membrane fouling in submerged membrane bioreactors. Sep. Purif. Technol. 51 (2006) 95-103
26. Lesjean B., Rosenberger S., Laabs C., Jekel V., Gnirss R., and Amy G. Correlation between membrane fouling and soluble/colloidal organic substances in membrane bioreactors for municipal wastewater treatment. Water Sci. Technol. 51 (2005) 1-8
27. Zhang J., Chua H.C., Zhou J., and Fane A.G. Factors affecting the membrane performance in submerged membrane bioreactors. J. Membr. Sci. 284 (2006) 54
28. Vocks M., Bracklow U., Drews A., Lesjean B., Mante J., and Kraume M. Comparison of polysaccharide concentration and fouling rates in different membrane activated sludge systems. Desalination 199 (2006) 381-383
29. Drews A., Vocks M., Iversen V., Lesjean B., and Kraume M. Influence of unsteady membrane bioreactor operation on EPS formation and filtration resistance. Desalination 192 (2006) 1-9
30. Thanh B.X., Visvanathan C., Spérandio M., and Ben Aim R. Fouling characterization in aerobic granulation coupled baffled membrane separation unit. J. Membr. Sci. 318 (2008) 334-339
31. Nataraj S., Schomäcker R., Kraume M., Mishra I.M., and Drews A. Analyses of polysaccharide fouling mechanisms during crossflow membrane filtration. J. Membr. Sci. 308 (2008) 152-161
32. Byrns G. The fate of xenobiotic organic compounds in wastewater treatment plants. Water Res. 35 (2001) 2523
33. Dionisi D., Bertin L., Bornoroni L., Capodicasa S., Petrangeli Papini M., and Fava F. Removal of organic xenobiotics in activated sludges under aerobic conditions and anaerobic digestion of the adsorbed species. J. Chem. Technol. Biotechnol. 81 (2006) 1496
34. Urase T., and Kikuta T. Separate estimation of adsorption and degradation of pharmaceutical substances and estrogens in the activated sludge process. Water Res. 39 (2005) 1289
35. Delgado L.F., Dorandeu C., Marion B., Gonzalez C., Faucet-Marquis V., Schetrite S., and Albasi C. Removal of a cytostatic drug by a membrane bioreactor. Desalination Water Treat. 9 (2009) 1-7
36. Frolund B., Griebe T., and Nielsen O.H. Enzymatic activity in the activated sludge flocs matrix. Appl. Microbiol. Biotechnol. 43 (1995) 755-761
37. Raunkjer K., Hvitved-Jacobsen T., and Nielsen P.H. Measurement of pools of protein, carbohydrate and lipid in domestic wastewater. Water Res. 28 (1994) 251-262
38. Christensen G.L., and Dick R.I. Specific resistance measurements: methods and procedures. J. Environ. Eng. 111 3 (1985) 258-271
39. Ognier S., Wisniewski C., and Grasmick A. Influence of macromolecular adsorption during filtration of a membrane bioreactor mixed liquor suspension. J. Membr. Sci. 209 (2002) 27-37
40. Howell J.A., Sanchez V., and Field R.W. Membranes in Bioprocessing-Theory and Applications (1993), Blackie Academic & Professional, Glasgow, UK
41. Boertage S.F.E., Kennedy M.D., Dickson M.R., El-Hodali D.E.Y., and Schippers J.C. The modified fouling index using ultrafiltration membranes (MFI-UF): characterization, filtration mechanisms and proposed reference membrane. J. Membr. Sci. 197 1-2 (2002) 15, 1-21
42. H. Spanjer, P.A. Vanrolleghem, G. Olsson, P.L. Dold, Respirometry in control of activated sludge process: principles, IAWQ Scientific and technical Report no. 7, IAWA Publishing, London, UK, 1998.
43. Acella A.C., Delgado L.F., Görner T., Albasi C., Galmiche M., and De Donato Ph. Effect of cytostatic drug presence on extracellular polymeric substances formation in municipal wastewater treated by membrane bioreactor. Bioresour. Technol. (2009) 10.1016/j.biortech.2009.08.057
44. Wisniewski C., and Grasmick A. Floc size distribution in a membrane bioreactor and consequences for membrane fouling. Colloids Surf. A Physicochem. Eng. Aspects 138 (1998) 403-411
45. Kim J.S., Lee C.H., and Chang I.S. Effect of pump shear on the performance of a crossflow membrane bioreactor. Water Res. 35 (2001) 2137-2144
46. Wingender J., Neu T.R., and Flemming H.C. What are bacterial extracellular polymer substances?. In: Wingender J., Neu T.R., and Flemming H.C. (Eds). Microbial Extracellular Polymeric Substances (1999), Springer, Heidelberg 1-19
47. Henriques I.D.S., and Love N.G. The role of extracellular polymeric substances in the toxicity response of activated sludge bacteria to chemical toxins. Water Res. 41 18 (2007) 4177-4185
48. Delgado L.F., Schetrite S., Gonzales C., and Albasi C. Effect of cytostatic drugs on microbial behaviour in membrane bioreactor system. Bioresour. Technol. (2009) 10.1016/j.biortech.2009.08.051
49. Lapasin R., and Pricl S. Rheology of Industrial Polysaccharides: Theory and Applications. first ed. (1995), Blackie Academic & Professional, London, New York
50. Laurent L., and Junter G.A. Diffusion of dextran through microporous membrane filters. J. Membr. Sci. 88 (1994) 253-261
51. Wang X.M., and Waite T.D. Retention of soluble microbial products in submerged membrane bioreactor. Proceeding of the Membranes in Drinking Water Production and Wastewater Treatment congress. Toulouse, France (2008)