Unbound cephalothin pharmacokinetics in adult burn patients are related to the elapsed time after injury

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 12, 2009, Pages 5303-5305

  Dalley, Andrew J ^a   Deans, Renae ^a,b   Lipman, Jeffrey ^a,b   Venkatesh, Bala ^c   Rudd, Michael ^a,b   Roberts, Michael S ^a   Cross, Sheree E ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c PRINCESS ALEXANDRA HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CEFALOTIN;

ADULT; ARTICLE; BODY SURFACE; BURN; CLINICAL ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; FEMALE; FLUID RESUSCITATION; HUMAN; HUMAN TISSUE; INJURY SEVERITY; MALE; MEAN RESIDENCE TIME; OPEN STUDY; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE;

ADULT; ANTI-BACTERIAL AGENTS; BURNS; CEPHALOTHIN; FEMALE; HUMANS; MALE; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 71249122271     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01600-08     Document Type: Article

References (12)

1. Almeida, A. M., M. M. Castel-Branco, and A. C. Falcão. 2002. Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods. J. Chromatogr. B 774:215-222.
2. Blanchet, B., V. Jullien, C. Vinsonneau, and M. Tod. 2008. Influence of burns on pharmacokinetics and pharmacodynamics of drugs used in the care of burn patients. Clin. Pharmacokinet. 47:635-654.
3. Cockcroft, D. W., and M. H. Gault. 1976. Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41.
4. Dalley, A. J., J. Lipman, R. Deans, B. Venkatesh, M. Rudd, M. S. Roberts, and S. E. Cross. 2009. Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers. Antimicrob. Agents Chemother. 53:210-215.
5. Dalley, A. J., J. Lipman, B. Venkatesh, M. Rudd, M. S. Roberts, and S. E. Cross. 2007. Inadequate antimicrobial prophylaxis during surgery: a study of beta-lactam levels during burn debridement. J. Antimicrob. Chemother. 60:166-169.
6. Dulhunty, J. M., R. J. Boots, M. J. Rudd, M. J. Muller, and J. Lipman. 2008. Increased fluid resuscitation can lead to adverse outcomes in major-burn injured patients, but low mortality is achievable. Burns 34:1090-1097.
7. Gehan, E. A., and S. L. George. 1970. Estimation of human body surface area from height and weight. Cancer Chemother. Rep. 54:225-235.
8. Knaus, W. A., E. A. Draper, D. P. Wagner, and J. E. Zimmerman. 1985. APACHE-II: a severity of disease classification-system. Crit. Care Med. 13:818-829.
9. Mohr, J. F., L. Ostrosky-Zeichner, D. J. Wainright, D. H. Parks, T. C. Hollenbeck, and C. D. Ericsson. 2008. Pharmacokinetic evaluation of singledose intravenous daptomycin in patients with thermal burn injury. Antimicrob. Agents Chemother. 52:1891-1893.
10. Pinder, M., R. Bellomo, and J. Lipman. 2002. Pharmacological principles of antibiotic prescription in the critically ill. Anaesth. Intensive Care 30:134-144. (Pubitemid 34326595)
11. Roberts, J. A., and J. Lipman. 2006. Antibacterial dosing in intensive care - pharmacokinetics, degree of disease and pharmacodynamics of sepsis. Clin. Pharmacokinet. 45:755-773.
12. Vincent, J. L., R. Moreno, J. Takala, S. Willatts, A. DeMendonca, H. Bruining, C. K. Reinhart, P. M. Suter, and L. G. Thijs. 1996. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/ failure. Intensive Care Med. 22:707-710.