Case of fatal Blastoschizomyces capitatus infection occurring in a patient receiving empiric micafungin therapy

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 12, 2009, Pages 5306-5307

  Chittick, Paul ^a   Palavecino, Elizabeth L ^a   Delashmitt, Brian ^a   Evans, James ^a   Peacock Jr , James E ^a  

^a WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMPHOTERICIN B LIPID COMPLEX; CEFEPIME; CYTARABINE; DAUNORUBICIN; ECHINOCANDIN; FLUCONAZOLE; MEROPENEM; MICAFUNGIN; MOXIFLOXACIN; VANCOMYCIN; VORICONAZOLE;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ARTICLE; BLASTOSCHIZOMYCES CAPITATUS; BLASTOSCHIZOMYCES CAPITATUS INFECTION; BLOOD CULTURE; BLOODSTREAM INFECTION; BONE MARROW BIOPSY; CASE REPORT; COAGULASE NEGATIVE STAPHYLOCOCCUS; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEBRILE NEUTROPENIA; FUNGUS; HUMAN; KIDNEY DISEASE; LIVER DYSFUNCTION; MALE; NONHUMAN; PANCYTOPENIA; PARENTERAL NUTRITION; PERIPHERALLY INSERTED CENTRAL VENOUS CATHETER; PRIORITY JOURNAL;

AGED; ANTIFUNGAL AGENTS; ECHINOCANDINS; FATAL OUTCOME; GEOTRICHOSIS; GEOTRICHUM; HUMANS; LIPOPEPTIDES; MALE; MICROBIAL SENSITIVITY TESTS; NEUTROPENIA;

EID: 71249102563     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00710-09     Document Type: Article

References (13)

1. Bouza, E., and P. Munoz. 2004. Invasive infections caused by Blastoschizomyces capitatus and Scedosporium spp. Clin. Microbiol. Infect. 10(Suppl. 1):76-85.
2. Christakis, G., S. Perlorentzou, M. Aslanidou, A. Megalakaki, and A. Velegraki. 2005. Fatal Blastoschizomyces capitatus sepsis in a neutropenic patient with acute myeloid leukemia: first documented case from Greece. Mycoses 48:216-220.
3. D'Antonio, D., A. Mazzoni, A. Iacone, B. Violante, M. A. Capuani, F. Schioppa, and F. Romano. 1996. Emergence of fluconazole-resistant strains of Blastoschizomyces capitatus causing nosocomial infections in cancer patients. J. Clin. Microbiol. 34:753-755.
4. DeMaio, J., and L. Colman. 2000. The use of adjuvant interferon-γ therapy for hepatosplenic Blastoschizomyces capitatus infection in a patient with leukemia. Clin. Infect. Dis. 31:822-824.
5. Hughes, W. T., D. Armstrong, G. P. Bodey, E. J. Bow, A. E. Brown, T. Calandra, R. Feld, P. A. Pizzo, K. V. Rolston, J. L. Shenep, and L. S. Young. 2002. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin. Infect. Dis. 34:730-751.
6. Kartsonis, N., J. Killar, L. Mixson, C. M. Hoe, C. Sable, K. Bartizal, and M. Motyl. 2005. Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome. Antimicrob. Agents Chemother. 49:3616-3623.
7. Krcmery, V., I. Krupova, and D. W. Denning. 1999. Invasive yeast infections other than Candida spp. in acute leukaemia. J. Hosp. Infect. 41:181-194.
8. Lee, J. J., H. C. Song, I. J. Chung, H. S. Bom, D. Cho, and H. J. Kim. 2004. Clinical efficacy and prediction of response to granulocyte transfusion therapy for patients with neutropenia-related infections. Haematologica 89:632-633.
9. Martino, R., M. Salavert, R. Parody, J. F. Tomás, R. de la Cámara, L. Vázquez, I. Jarque, E. Prieto, J. L. Sastre, I. Gadea, J. Pemán, and J. Sierra. 2004. Blastoschizomyces capitatus infection in patients with leukemia: report of 26 cases. Clin. Infect. Dis. 38:335-341.
10. Pagano, L., G. Morace, E. Ortu-La Barbera, M. Sanquinetti, and G. Leone. 1996. Adjuvant therapy with rhGM-CSF for the treatment of Blastoschizomyces capitatus systemic infection in a patient with acute myeloid leukemia. Ann. Hematol. 73:33-34.
11. Perez-Sanchez, I., J. Anguita, P. Martin-Rabadan, P. Munoz, D. Serrano, A. Escudero, and T. Pintado. 2000. Blastoschizomyces capitatus infection in acute leukemia patients. Leuk. Lymphoma 39:209-212.
12. Serena, C., M. Marine, R. Marimon, F. J. Pastor, and J. Guarro. 2007. Effect of antifungal treatment in a murine model of blastoschizomycosis. Int. J. Antimicrob. Agents 29:79-83.
13. Venditti, M., B. Posteraro, G. Morace, and P. Martino. 1991. In-vitro comparative activity of fluconazole and other antifungal agents against Blastoschizomyces capitatus. J. Chemother. 3:13-15.