Prostaglandin treatment is associated with a withdrawal of progesterone and androgen at the receptor level in the uterine cervix

Reproductive Biology and Endocrinology

Volumn 7, Issue , 2009, Pages

  Vladic Stjernholm, Ylva ^a   Vladic, Tomislav ^b   Blesson, Chellakkan S ^a   Ekman Ordeberg, Gunvor ^a   Sahlin, Lena ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; PROGESTERONE RECEPTOR; PROSTAGLANDIN E2; SEX HORMONE BINDING GLOBULIN; ANDROGEN; PROGESTERONE; SEX HORMONE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; IMMUNOHISTOCHEMISTRY; LABOR INDUCTION; NUCLEOTIDE SEQUENCE; PROLONGED PREGNANCY; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERINE CERVIX; BLOOD; CLINICAL TRIAL; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; PREGNANCY; TREATMENT OUTCOME;

PARUS;

ADULT; ANDROGENS; CERVIX UTERI; DINOPROSTONE; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; HUMANS; LABOR, INDUCED; PREGNANCY; PROGESTERONE; RECEPTORS, ANDROGEN; RECEPTORS, PROGESTERONE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 71149096488     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-7-116     Document Type: Article

References (37)

1. Hertelendy F, Zakar T. Prostaglandins and the myometrium and cervix. Prostagl, Leukot Essen Fatty Acids 2004, 70(2):207-222.
2. Ekman G, Uldbjerg N, Malmstrom A, Ulmsten U. Increased postpartum collagenolytic activity in cervical connective tissue from women treated with prostaglandin E2. Gynecol Obstet Invest 1983, 16(5):292-298.
3. Lindström K, Fernell E, Westgren M. Developmental data in preschool children born after prolonged pregnancy. Acta Paediatrica 2005, 94(9):1192-1197.
4. Crowley P. Interventions for preventing or improving the outcome of delivery at or beyond term. Cochrane Database of Systematic Reviews 2000, (2):CD000170.
5. WHO WHO: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended October 14, 1976. Acta Obstet Gynecol Scand 1977, 56(3):247-253.
6. Sennstrom MB, Ekman G, Westergren-Thorsson G, Malmstrom A, Bystrom B, Endresen U, Mlambo N, Norman M, Stabi B, Brauner A. Human cervical ripening, an inflammatory process mediated by cytokines. Mol Hum Reprod 2000, 6(4):375-381. 10.1093/molehr/6.4.375, 10729321.
7. Stygar D, Wang H, Vladic YS, Ekman G, Eriksson H, Sahlin L. Increased level of matrix metalloproteinases 2 and 9 in the ripening process of the human cervix. Biol Reprod 2002, 67(3):889-894. 10.1095/biolreprod.102.005116, 12193399.
8. Almawi WY, Melemedjian OK. Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor. J Leuk Biol 2002, 71(1):9-15.
9. Stites DP, Siiteri PK. Steroids as immunosuppressants in pregnancy. Immunol Rev 1983, 75:117-138. 10.1111/j.1600-065X.1983.tb01093.x, 6226589.
10. Stjernholm-Vladic Y, Wang H, Stygar D, Ekman G, Sahlin L. Differential regulation of the progesterone receptor A and B in the human uterine cervix at parturition. Gynecol Endocrin 2004, 18(1):41-46.
11. Stjernholm Y, Sahlin L, Malmstrom A, Barchan K, Eriksson HA, Ekman G. Potential roles for gonadal steroids and insulin-like growth factor I during final cervical ripening. Obstet Gynecol 1997, 90(3):375-380. 10.1016/S0029-7844(97)00245-7, 9277647.
12. Smith R, Mesiano S, McGrath S. Hormone trajectories leading to human birth. Regul Pept 2002, 108(2-3):159-164. 10.1016/S0167-0115(02)00105-2, 12220740.
13. Bishop EH. Pelvic Scoring for Elective Induction. Obstet Gynecol 1964, 24:266-268.
14. O'Driscoll K, Foley M, MacDonald D. Active management of labor as an alternative to cesarean section for dystocia. Obstet Gynecol 1984, 63(4):485-490.
15. Watson WJ, Stevens D, Welter S, Day D. Factors predicting successful labor induction. Obstet Gynecol 1996, 88(6):990-992. 10.1016/S0029-7844(96)00321-3, 8942840.
16. Gustafsson O, Norming U, Gustafsson S, Eneroth P, Astrom G, Nyman CR. Dihydrotestosterone and testosterone levels in men screened for prostate cancer: a study of a randomized population. Br J Urol 1996, 77(3):433-440.
17. Mendel CM. The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 1989, 10(3):232-274. 10.1210/edrv-10-3-232, 2673754.
18. Pardridge WM. Serum bioavailability of sex steroid hormones. Clin Endocrin Metab 1986, 15(2):259-278.
19. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. 2000, 132.
20. Wang H, Masironi B, Eriksson H, Sahlin L. A comparative study of estrogen receptors alpha and beta in the rat uterus. Biol Reprod 1999, 61(4):955-964. 10.1095/biolreprod61.4.955, 10491630.
21. Granström L, Ekman G, Malmstrom A. Insufficient remodelling of the uterine connective tissue in women with protracted labour. Br J Obst Gyn 1991, 98(12):1212-1216.
22. Norman M, Ekman G, Malmstrom A. Prostaglandin E2-induced ripening of the human cervix involves changes in proteoglycan metabolism. Obstet Gynecol 1993, 82(6):1013-1020.
23. Madsen G, Zakar T, Ku CY, Sanborn BM, Smith R, Mesiano S. Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal. J Clin Endocrin Metab 2004, 89(2):1010-1013.
24. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function. Mol Endocrin 1993, 7(10):1244-1255.
25. Coleman RA, Smith WL, Narumiya S. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol Rev 1994, 46(2):205-229.
26. Denison FC, Calder AA, Kelly RW. The action of prostaglandin E2 on the human cervix: stimulation of interleukin 8 and inhibition of secretory leukocyte protease inhibitor. Am J Obstet Gynecol 1999, 180(3 Pt 1):614-620. 10.1016/S0002-9378(99)70263-2, 10076137.
27. Sahlin L, Stjernholm-Vladic Y, Roos N, Masironi B, Ekman-Ordeberg G. Impaired leukocyte influx in cervix of postterm women not responding to prostaglandin priming. Reprod Biol Endocrin 2008, 6:36.
28. Kalkhoven E, Wissink S, Saag PT, Burg B. Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor. JBC 1996, 271(11):6217-6224.
29. Molnar M, Rigo J, Romero R, Hertelendy F. Oxytocin activates mitogen-activated protein kinase and up-regulates cyclooxygenase-2 and prostaglandin production in human myometrial cells. Am J Obstet Gynecol 1999, 181(1):42-49. 10.1016/S0002-9378(99)70434-5, 10411794.
30. Leguizamon G, Smith J, Younis H, Nelson DM, Sadovsky Y. Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios. Am J Obstet Gynecol 2001, 184(2):117-122. 10.1067/mob.2001.108076, 11174490.
31. Gornstein RA, Lapp CA, Bustos-Valdes SM, Zamorano P. Androgens modulate interleukin-6 production by gingival fibroblasts in vitro. J Periodont 1999, 70(6):604-609. 10.1902/jop.1999.70.6.604, 10397515.
32. Ji H, Dailey TL, Long V, Chien EK. Androgen-regulated cervical ripening: a structural, biomechanical, and molecular analysis. Am J Obstet Gynecol 2008, 198(5):e541-549.
33. D'Agostino P, Milano S, Barbera C, Di Bella G, La Rosa M, Ferlazzo V, Farruggio R, Miceli DM, Miele M, Castagnetta L, Cillari E. Sex hormones modulate inflammatory mediators produced by macrophages. Ann NY Acad Sci 1999, 876:426-429. 10.1111/j.1749-6632.1999.tb07667.x, 10415638.
34. Ishikawa T, Harada T, Kubota T, Aso T. Testosterone inhibits matrix metalloproteinase-1 production in human endometrial stromal cells in vitro. Reproduction 2007, 133(6):1233-1239. 10.1530/rep.1.01089, 17636177.
35. Stjernholm-Vladic Y, Stygar D, Mansson C, Masironi B, Akerberg S, Wang H, Ekman-Ordeberg G, Sahlin L. Factors involved in the inflammatory events of cervical ripening in humans. Reprod Biol Endocrinol 2004, 2:74. 10.1186/1477-7827-2-74, 534613, 15500686.
36. Stjernholm YM, Sahlin L, Eriksson HA, Bystrom BE, Stenlund PM, Ekman GE. Cervical ripening after treatment with prostaglandin E2 or antiprogestin (RU486). Possible mechanisms in relation to gonadal steroids. Eur J Obstet Gynecol RB 1999, 84(1):83-88.
37. Kastner P, Krust A, Turcotte B, Stropp U, Tora L, Gronemeyer H, Chambon P. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J 1990, 9(5):1603-1614. 551856, 2328727.