Mast cells and macrophages in duodenal mucosa of mice overexpressing erythropoietin

Journal of Anatomy

Volumn 215, Issue 5, 2009, Pages 548-554

  Ribatti, Domenico ^a   Crivellato, Enrico ^b   Nico, Beatrice ^a   Guidolin, Diego ^c   Gassmann, Max ^d   Djonov, Valentin ^e  

^a UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^b UNIVERSITY OF UDINE   (Italy)

^c UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Duodenum; Erythropoietin; Erythropoietin receptor; Macrophages; Mast cells; Tg6 mouse

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; STEM CELL FACTOR RECEPTOR; TRYPTASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DUODENUM MUCOSA; ENDOTHELIUM CELL; EPITHELIUM CELL; ERYTHROPOIESIS; EXPERIMENTAL MODEL; GENE OVEREXPRESSION; HEART MUSCLE CELL; IMAGE ANALYSIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM; INTESTINE VILLUS; MACROPHAGE; MAST CELL; MEGAKARYOCYTE; MORPHOMETRICS; MOUSE; NERVE CELL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; WILD TYPE;

ANIMALS; CELL COUNT; DUODENUM; EPITHELIAL CELLS; ERYTHROPOIETIN; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTESTINAL MUCOSA; MACROPHAGES; MALE; MAST CELLS; MICE; MICE, TRANSGENIC; TRYPTASES;

ANIMALIA; MUS;

EID: 71049194713     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2009.01131.x     Document Type: Article

References (42)

1. Anagnostou A, Liu Z, Steiner M. Erythropoietin receptor mRNA expression in human endothelial cells. Proc Natl Acad Sci USA 1994, 91:3974-3978.
2. Bernaudin M, Bellail A, Marti HH. Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia 2000, 30:271-278.
3. Besag J, Diggle PJ. Simple Monte Carlo tests for spatial pattern. Appl Stat 1997, 26:327-333.
4. Bischoff SC, Machel H, Stolte M. Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease. Histopathology 1996, 28:1-13.
5. Bogdanova A, Mihov D, Lutz H. Enhanced erytro-phagocytosis in polycythemic mice overexpressing erythropoietin. Blood 2007, 110:762-769.
6. Broudy VC. Stem cell factor and hematopoiesis. Blood 1997, 90:1345-1364.
7. Buemi M, Cavallaro E, Floccari F. The pleiotropic effects of erythropoietin in the central nervous system. J Neuropathol Exp Neurol 2003, 62:228-236.
8. Diggle PJ. Statistical Analysis of Spatial Point Patterns 1983, London, Academic Press
9. Digicalylioglu M, Bichet S, Marti HH. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci U S A 1995, 92:3717-3720.
10. Elliott S, Lorenzini T, Chang J. Fine-structure epitope mapping of antierythropoietin monoclonal antibodies reveals a model of recombinant human erythropoietin structure. Blood 1996, 87:2702-2713.
11. Fraser JK, Tan AS, Lin FK, Berridge MV. Expression of specific high-affinity binding sites for erythropoietin on rat and mouse megakaryocytes. Exp Hematol 1989, 17:10-16.
12. Guidolin D, Crivellato E, Nico B. An image analysis of the spatial distribution of perivascular mast cells in human melanoma. Int J Mol Med 2006, 17:981-987.
13. Heinicke K, Baum O, Ogunshola OO. Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration. Am J Physiol Regul Integr Comp Physiol 2006, 291:R947-R956.
14. Hirose S, Takahashi M, Ogawa R. Erythropoietin attenuates the development of experimental autoimmune myocarditis. Cardiovasc Drugs Ther 2007, 21:17-27.
15. Isogai R, Takahashi M, Aisu K. The receptor for erythropoietin is present on cutaneous mast cell. Arch Dermatol Res 2006, 297:389-394.
16. Juul SE, Yachnis AT, Christensen RD. Tissue distribution of erythropoietin and erythropoietin receptor in the developing human fetus. Early Hum Dev 1998, 52:235-249.
17. Kamitani H, Masuzawa H, Sato J. Erythropoietin in haemangioblastoma: immunohistochemical and electron microscopy studies. Acta Neurochir (Wien) 1987, 85:56-62.
18. Katz O, Gil L, Lifshitz L. Erythropoietin enhances immune responses in mice. Eur J Immunol 2007, 37:1584-1593.
19. Kitamura Y, Go S, Hatanaka K. Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood 1978, 52:447-452.
20. Lifshitz L, Prutchi-Sagiv S, Avneon M. Non-erythroid activities of erythropoietin: functional effects on murine dendritic cells. Mol Immunol 2009, 46:713-721.
21. Lin CS, Lim SK, D'Agati V, Costantini F. Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev 1996, 10:154-164.
22. Malorny U, Michels E, Sorg C. A monoclonal antibody against an antigen present on mouse macrophages and absent from monocytes. Cell Tissue Res 1986, 243:421-428.
23. Ogunshola OO, Djonov V, Staudt R. Chronic excessive erythrocytosis induces endothelial activation and damage in mouse brain. Am J Physiol Regul Integr Comp Physiol 2005, 290:R678-R684.
24. Philimonenko AA, Janàcek J, Hozàk P. Statistical evaluation of colocalization patterns in immunogold labeling experiments. J Struct Biol 2000, 132:201-210.
25. Platt AM, Mowat AM. Mucosal macrophages and the regulation of the immune response in the intestine. Immunol Lett 2008, 119:22-31.
26. R: A Language and Environment for Statistical Computing 2005, http://www.R-project.org, Reference index version 2.0.0, R foundation for Statistical Computing, Vienna, ISBN 3-900051-07-0. Available at: (accessed on 01 July 2005)
27. Ribatti D, Presta M, Vacca A. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood 1999, 93:2627-2636.
28. Ripley BD. Tests for randomness for spatial point patterns. J R Statist Soc 1979, 41:368-374.
29. Ruschitkka FT, Wenger RH, Stallmach T. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci USA 2000, 97:11609-11613.
30. Sakanaka M, Wen TC, Matsuda S. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci U S A 1998, 95:4635-4640.
31. Sela S, Shurtz-Swirski R, Sharon R. The polymorphonuclear leukocyte-a new target for erythropoietin. Nephron 2001, 88:205-210.
32. Spivak IL. Polycythemia vera: myths, mechanisms, and management. Blood 2002, 100:4272-4290.
33. Tachibana O, Yamashima T, Yamashita J. Immunohistochemical study of erythropoietin in cerebellar hemangioblastomas associated with secondary polycythemia. Neurosurgery 1991, 28:24-26.
34. Tilbrook PA, Klinken SP. Erythropoietin and erythropoietin receptor. Growth Factors 1999, 17:25-35.
35. Vogel J, Kiessling I, Heinicke K. Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Blood 2003, 102:2278-2284.
36. Wagner KF, Kastchinski DM, Hasegawa J. Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood 2001, 97:536-542.
37. Waskow C, Rodewald HR. Lymphocyte development in neonatal and adult c-Kit-deficient (c-KitW/W) mice. Adv Exp Med Biol 2002, 512:1-10.
38. Waskow C, Paul S, Haller C. Viable c-KitW/W mutants reveal pivotal role for c-Kit in the maintenance of lymphopoiesis. Immunity 2002, 17:277-288.
39. Waskow C, Terszowski G, Costa C. Rescue of lethal c-KitW/W mice by erythropoietin. Blood 2004, 104:1688-1695.
40. Welham MJ, Schrader JW. Modulation of c-kit mRNA and protein by hemopoietic growth factors. Mol Cell Biol 1991, 11:2901-2904.
41. Wiessner C, Allegrini PR, Ekatodramis D. Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin. J Cereb Blood Flow Metab 2001, 21:857-864.
42. Wu H, Liu X, Janisch R. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995, 83:59-67.