Study of degradation profile and development of stability indicating methods for cefixime trihydrate

Indian Journal of Pharmaceutical Sciences

Volumn 71, Issue 4, 2009, Pages 438-442

  Gandhi, S P ^a   Rajput, S J ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Cefixime trihydrate; Spectrophotometry; Stress degradation

Indexed keywords

CEFIXIME;

ACCURACY; ARTICLE; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG OXIDATION; DRUG STABILITY; PH; SENSITIVITY AND SPECIFICITY; ULTRAVIOLET SPECTROPHOTOMETRY; VALIDATION STUDY;

EID: 71049187270     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.57295     Document Type: Article

References (8)

1. ICH harmonized tripartite guideline, stability testing of new drug substances and products, Q1A(R2) Feb, 2003. p. 1-15
2. United States Pharmacopoeia, 30th ed, Rockville, MD: USP Convention Inc; 2007. p. 1654.
3. British Pharmacopoeia, British Pharmacopoeia Commission. Vol.1, London: Her Majesty's Stationary Office; 2009. p. 397.
4. European Pharmacopoeia, Council of Europe. 3rd ed, Strasbourg, France,: EDQM Publications; 2000. p. 504.
5. Nahata MC. Measurement of Cefixime in serum and cerebrospinal fluid by high performance liquid chromatography. J Liq Chromatogr 1991;14:3755-3760
6. Eric-Jovanovic S, Agbaba D, Zivanov-Stakic D, Vladimirov S. HPTLC Determination of Ceftriaxone, Cefixime and Ceftaxime in dosage forms. J Pharm Biomed Anal 1998;18:893-897
7. Baertschi SW, Dorman DE, Occlowitz JL, Spangle LA, Collins MW, Wildfeuer ME et al. Isolation and structure elucidation of a novel product of acidic degradation of cefaclor. J Pharm Sci 1993;82:622-626
8. Skibic MJ, Taylor KW, Occlowitz JL, Collins MW, Paschal JW, Lorenz LJ et al. Aqueous acidic degradation of carbacephalosporin in loracarbef. J Pharm Sci 1993;82:1010-1014