BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization

Cancer Science

Volumn 100, Issue 11, 2009, Pages 2115-2125

  Niwa, Takayoshi ^a,b   Saito, Hiroko ^b   Imajoh ohmi, Shinobu ^c   Kaminishi, Michio ^a   Seto, Yasuyuki ^a   Miki, Yoshio ^b,d   Nakanishi, Akira ^b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b CANCER INSTITUTE   (Japan)

^c THE UNIVERSITY OF TOKYO   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; BRCA2 PROTEIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOSKELETON PROTEIN; DNA; GAMMA TUBULIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; PLECTIN; SMALL INTERFERING RNA; VIMENTIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CELL STRAIN COS7; CELL STRAIN MCF 7; CENTROSOME; COMPLEX FORMATION; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC STABILITY; HELA CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; MICRONUCLEUS; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY;

APOPTOSIS REGULATORY PROTEINS; BRCA2 PROTEIN; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; CELL NUCLEUS; CENTROSOME; CYCLIN B; CYCLIN B1; HUMANS; IMMUNOPRECIPITATION; NEOPLASMS; PLECTIN; PROTEIN STRUCTURE, TERTIARY;

EID: 71049185569     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01282.x     Document Type: Article

References (38)

1. Wooster R, Bignell G, Lancaster J. Identification of the breast cancer susceptibility gene BRCA2. Nature 1995, 378:789-92.
2. Venkitaraman A. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2002, 108:171-82.
3. Pellegrini L, Venkitaraman A. Emerging functions of BRCA2 in DNA recombination. Trends Biochem Sci 2004, 29:310-6.
4. Esashi F, Christ N, Gannon J. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005, 434:598-604.
5. Wong A, Pero R, Ormonde P, Tavtigian S, Bartel P. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 1997, 272:31941-4.
6. Yang H, Li Q, Fan J, Holloman W, Pavletich N. The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature 2005, 433:653-7.
7. Tutt A, Gabriel A, Bertwistle D. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification. Curr Biol 1999, 9:1107-10.
8. Daniels M, Wang Y, Lee M, Venkitaraman A. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science 2004, 306:876-9.
9. Han X, Saito H, Miki Y, Nakanishi A. A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2. Oncogene 2008, 27:2969-77.
10. Nakanishi A, Han X, Saito H. Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division. Biochem Biophys Res Commun 2007, 355:34-40.
11. Foisner R, Bohn W, Mannweiler K, Wiche G. Distribution and ultrastructure of plectin arrays in subclones of rat glioma C6 cells differing in intermediate filament protein (vimentin) expression. J Struct Biol 1995, 115:304-17.
12. Foisner R, Wiche G. Structure and hydrodynamic properties of plectin molecules. J Mol Biol 1987, 198:515-31.
13. McMillan J, Akiyama M, Rouan F. Plectin defects in epidermolysis bullosa simplex with muscular dystrophy. Muscle Nerve 2007, 35:24-35.
14. Cheng C, Liu Y, Ho C. The influence of plectin deficiency on stability of cytokeratin18 in hepatocellular carcinoma. J Mol Histol 2008, 39:209-16.
15. Kelly K, Bardeesy N, Anbazhagan R. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med 2008, 5:e85.
16. Svitkina T, Verkhovsky A, Borisy G. Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. J Cell Biol 1996, 135:991-1007.
17. Andrä K, Nikolic B, Stöcher M, Drenckhahn D, Wiche G. Not just scaffolding: plectin regulates actin dynamics in cultured cells. Genes Dev 1998, 12:3442-51.
18. Nikolic B, Mac Nulty E, Mir B, Wiche G. Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions. J Cell Biol 1996, 134:1455-67.
19. Wiche G. Role of plectin in cytoskeleton organization and dynamics. J Cell Sci 1998, 111(Pt 17):2477-86.
20. Boczonadi V, McInroy L, Määttä A. Cytolinker cross-talk: periplakin N-terminus interacts with plectin to regulate keratin organisation and epithelial migration. Exp Cell Res 2007, 313:3579-91.
21. Spurny R, Gregor M, Castañón M, Wiche G. Plectin deficiency affects precursor formation and dynamics of vimentin networks. Exp Cell Res 2008, 314:3570-80.
22. Foisner R, Malecz N, Dressel N, Stadler C, Wiche G. M-phase-specific phosphorylation and structural rearrangement of the cytoplasmic cross-linking protein plectin involve p34cdc2 kinase. Mol Biol Cell 1996, 7:273-88.
23. Foisner R, Traub P, Wiche G. Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin. Proc Natl Acad Sci U S A 1991, 88:3812-6.
24. Wilhelmsen K, Litjens S, Kuikman I. Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin. J Cell Biol 2005, 171:799-810.
25. Malecz N, Foisner R, Stadler C, Wiche G. Identification of plectin as a substrate of p34cdc2 kinase and mapping of a single phosphorylation site. J Biol Chem 1996, 271:8203-8.
26. Janda L, Damborský J, Rezniczek G, Wiche G. Plectin repeats and modules: strategic cysteines and their presumed impact on cytolinker functions. BioEssays 2001, 23:1064-9.
27. Mosavi L, Cammett T, Desrosiers D, Peng Z. The ankyrin repeat as molecular architecture for protein recognition. Protein Sci 2004, 13:1435-48.
28. Vallee R, Stehman S. How dynein helps the cell find its center: a servomechanical model. Trends Cell Biol 2005, 15:288-94.
29. Burakov A, Nadezhdina E, Slepchenko B, Rodionov V. Centrosome positioning in interphase cells. J Cell Biol 2003, 162:963-9.
30. Foisner R, Feldman B, Sander L, Wiche G. Monoclonal antibody mapping of structural and functional plectin epitopes. J Cell Biol 1991, 112:397-405.
31. Malone C, Misner L, Le Bot N. The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus. Cell 2003, 115:825-36.
32. Gönczy P. Centrosomes: hooked on the nucleus. Curr Biol 2004, 14:R268-70.
33. Salpingidou G, Smertenko A, Hausmanowa-Petrucewicz I, Hussey P, Hutchison C. A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. J Cell Biol 2007, 178:897-904.
34. Basto R, Brunk K, Vinadogrova T. Centrosome amplification can initiate tumorigenesis in flies. Cell 2008, 133:1032-42.
35. Castellanos E, Dominguez P, Gonzalez C. Centrosome dysfunction in drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol 2008, 18:1209-14.
36. Lingle W, Barrett S, Negron V. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci U S A 2002, 99:1978-83.
37. Fenech M. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov Today 2002, 7:1128-37.
38. Bonassi S, Znaor A, Ceppi M. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 2007, 28:625-31.