Electrophysiological evidence of cerebellar fiber system involvement in the Miller Fisher syndrome

Journal of the Neurological Sciences

Volumn 288, Issue 1-2, 2010, Pages 49-53

  Lo, Y L ^a   Fook Chong, S ^a   Chan, L L ^a   Ong, W Y ^b   Ratnagopal, P ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Anti GQ1b IgG antibody; Ballistic movement; Cerebellum; Miller Fisher syndrome; Transcranial magnetic stimulation

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

ADULT; ARTICLE; CASE REPORT; CEREBELLUM DISEASE; ELECTROPHYSIOLOGY; GUILLAIN BARRE SYNDROME; HUMAN; MALE; MOTOR PERFORMANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; BRAIN; CEREBELLUM; DATA INTERPRETATION, STATISTICAL; ELECTROMYOGRAPHY; ELECTROPHYSIOLOGY; EVOKED POTENTIALS, MOTOR; FEMALE; GANGLIOSIDES; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MILLER FISHER SYNDROME; NERVE FIBERS; PSYCHOMOTOR PERFORMANCE; REACTION TIME; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 71049180942     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2009.10.008     Document Type: Article

References (21)

1. Fisher M. An unusual variant of acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia). N Engl J Med 255 (1956) 57-65
2. Weiss J.A., and White J.C. Correlation of 1a afferent conduction with ataxia of Fisher syndrome. Muscle Nerve 9 (1986) 327-332
3. Odaka M., Yuki N., and Hirata K. Bilateral ballism in a patient with overlapping Fisher's and Guillain-Barrè syndromes. J Neurol Neurosurg Psychiatry 67 (1999) 206-208
4. Ropper A.H., and Shahani B.T. Proposed mechanism of ataxia in Fisher's syndrome. Arch Neurol 40 (1983) 537-538
5. Flament D., and Hore J. Movement and electromyographic disorders associated with cerebellar dysmetria. J Neurophysiol 55 (1986) 1221-1233
6. Dee J., and Zangemeister W.H. Disturbances of antagonistic neck innervation in patients with cerebellar deficits. J Neurol Sci 155 (1998) 95-103
7. Lo Y.L., Fook-Chong S., Chan L.L., and Ong W.Y. Cerebellar control of motor activation and cancellation in humans: an electrophysiological study. Cerebellum 8 (2009) 302-311
8. Ugawa Y., Uesaka Y., Terao Y., Hanajima R., and Kanazawa I. Magnetic stimulation over the cerebellum in humans. Ann Neurol 37 (1995) 703-713
9. Lo Y.L., Chan L.L., Pan A., and Ratnagopal P. Acute ophthalmoparesis with anti-GQ1b antibody: electrophysiological evidence of neuromuscular transmission defect in the orbicularis oculi. J Neurol Neurosurg Psychiatry 75 (2003) 436-440
10. Thach W.T., Goodkin H.P., and Keating J.G. The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 15 (1992) 403-442
11. Kenyon G.T. A model of long-term memory storage in the cerebellar cortex: a possible role for plasticity at parallel fiber synapses onto stellate/basket interneurons. Proc Natl Acad Sci USA 94 (1997) 14200-14205
12. Chiba A., Kusunoki S., Shimizu T., and Kanazawa I. Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome. Ann Neurol 31 (1992) 677-679
13. Lo Y.L., and Ratnagopal P. Transcranial magnetic stimulation studies in the Miller Fisher syndrome: evidence of corticospinal tract abnormality. J Neurol Neurosurg Psychiatry 71 (2001) 210-214
14. Kuwabara S., Asahina M., Nakajima M., Mori M., Fukutake T., Hattori T., et al. Special sensory ataxia in Miller Fisher syndrome detected by postural body sway analysis. Ann Neurol 45 (1999) 533-536
15. Kusunoki S., Chiba A., and Kanazawa I. Anti-GQ1b IgG antibody is associated with ataxia as well as ophthalmoplegia. Muscle Nerve 22 (1999) 1071-1074
16. Liu J.X., Willison H.J., and Pedrosa-Domeliof F. Immunolocalization of GQ1b and related gangliosides in human extraocular neuromuscular junctions and muscle spindles. Invest Ophthalmol Vis Sci 50 (2009) 3226-3232
17. Kornberg A.J., Pestronk A., Blume G.M., Lopate G., Yue J., and Hahn A. Selective staining of the cerebellar molecular layer by serum IgG of Miller Fisher and related syndromes. Neurology 47 (1996) 1317-1320
18. Inoue A., Koh C., and Iwahashi T. Detection of serum anticerebellar antibodies in patients with Miller Fisher syndrome. Eur Neurol 42 (1999) 230-234
19. Nakatani Y., Murata M., Shibata K., Nagaoka T., Utsunomiya I., Usuki S., et al. IgM anti-GQ1b monoclonal antibody inhibits voltage-dependent calcium current in cerebellar granule cells. Exp Neurol 219 (2009) 74-80
20. Ugawa Y., Genba-Shimizu K., and Kanazawa I. Suppression of motor cortical excitability by electrical stimulation over the cerebellum in Fisher's syndrome. J Neurol Neurosurg Psychiatry 57 (1994) 1275-12746
21. Schols L., Bauer P., Schmidt T., Schulte T., and Riess O. Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancel Neurol 3 (2004) 291-304