Toward effective HIV vaccination. Induction of binary epitope reactive antibodies with broad HIV neutralizing activity

Journal of Biological Chemistry

Volumn 284, Issue 44, 2009, Pages 30627-30642

  Nishiyama, Yasuhiro ^a   Planque, Stephanie ^a   Mitsuda, Yukie ^a   Nitti, Giovanni ^a   Taguchi, Hiroaki ^a   Jin, Lei ^a   Symersky, Jindrich ^a   Boivin, Stephane ^a   Sienczyk, Marcin ^a   Salas, Maria ^b   Hanson, Carl V ^b   Paul, Sudhir ^a,c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-BINDING; COMPLEMENTARITY-DETERMINING REGIONS; EPITOPE MAPPING; FAB FRAGMENTS; GERM LINE; HEAVY CHAIN; HUMAN IMMUNODEFICIENCY VIRUS; MURINE MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODIES; NEUTRALIZING EPITOPE; PEPTIDE ANALOGS; PUTATIVE BINDING SITES; RANDOM MUTATION; SILENT MUTATIONS; SINGLE-CHAIN FV; SYNTHETIC PEPTIDE; VACCINE DEVELOPMENT;

AMINES; BINDING ENERGY; MONOCLONAL ANTIBODIES; OLIGOMERS; PEPTIDES; VIRUSES; X RAY CRYSTALLOGRAPHY;

BINDING SITES;

ALANINE; CD4 ANTIGEN; GLYCOPROTEIN GP 120; LYSINE; MONOCLONAL ANTIBODY;

AMINO ACID SUBSTITUTION; ANTIGEN BINDING; ANTIGEN STRUCTURE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TARGETING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; IMMUNIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VACCINATION; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS NEUTRALIZATION; VIRUS STRAIN; X RAY CRYSTALLOGRAPHY;

AIDS VACCINES; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD4; CRYSTALLOGRAPHY, X-RAY; EPITOPE MAPPING; EPITOPES; HIV ANTIBODIES; HUMANS; IMMUNOGLOBULIN FRAGMENTS; MICE; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PROTEIN CONFORMATION;

HUMAN IMMUNODEFICIENCY VIRUS; MURINAE;

EID: 71049167704     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.032185     Document Type: Article

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