Curcumin induces the expression of NF-κB and Bcl-2/Bax in human renal cell carcinoma cell line ACHN

Journal of Nanjing Medical University

Volumn 23, Issue 6, 2009, Pages 386-391

  Li, Gang ^a   Chong, Tie ^a   Wang, Ziming ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

apoptosis; Bcl 2; curcumin; NF B; renal cell carcinoma

Indexed keywords

CURCUMIN; PROTEIN BAX; PROTEIN BCL 2; TRANSCRIPTION FACTOR RELA;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL LINE; CELL PROLIFERATION; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 71049147207     PISSN: 10074376     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1007-4376(09)60087-3     Document Type: Article

References (17)

1. Carteni G., Grimaldi M., Guida T., Riccardi F., Biglietto M., Perrotta E., et al. Target therapy in metastatic renal cell carcinoma. EJC Supplements 6 (2008) 38-41
2. Antonio R.V.C., Michael E., Liang X.Y., and Michael T. The biology of interleukin-2 efficacy in the treatment of patients with renal cell carcinoma. Med Oncol 26 (2009) 13-19
3. Jing Z., Yong Z., Yan Z., and Wei C. Anti-tumor effect of curcumin on human cervical carcinoma HeLa cells in vitro and in vivo. Chinese J Cancer Res 19 (2007) 32-36 (in Chinese)
4. Mackenzie G.G., Queisser N., Wolfson M.L., Fraga C.G., Adamo A.M., and Oteiza P.I. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-κB and STAT3 pathways in Hodgkin's lymphoma cells. Int J Cancer 123 (2008) 56-65
5. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal Biochem 162 (1987) 156-159
6. Hwang M.K., Song N.R., Kang N.J., Lee K.W., and Lee H.J. Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin. Int J Biochem Cell Biol 41 (2009) 1592-1599
7. Lin J. Molecular targets of curcumin. Molecular Targets 595 (2007) 227-243
8. Jiao Y., Wilkinson J., Di X.M., and Wang W. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood 113 (2009) 462-469
9. Kang H., Lee S., Price J., and Kim L. Curcumin suppresses the paclitaxel-induced nuclear factor-kappa B in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model. Breast J 15 (2009) 223-229
10. Lin J., and Linshian S. Mechanisms of cancer chemoprevention by curcumin. Proc Natl Sci Counc Repub China B 25 (2001) 59-66
11. Lee H., Herrmann A., Deng J.H., Kujawski M., Niu G.L., Li Z.W., et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15 (2009) 283-293
12. Kucharczak J., Simmons M., Fan Y., and Gelinas C. To be or not to be: NF-kappaB is the answer-role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22 (2003) 8961-8982
13. Shishodia S., Singh T., and Chaturvedi M.M. Modulation of transcription factors by curcumin. Adv Exp Med Biol 595 (2007) 127-148
14. Lappas M., Odumetse T.L., Riley C., Reti N.G., Holdsworth-Carson S.J., Rice G.E., et al. Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kappa B signalling pathways. Placenta 29 (2008) 995-1002
15. Cory S., Huang D.C., and Adams J.M. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22 (2003) 8590-8607
16. Szoltysek K., Pietranek K., Kalinowska-Herok M., Pietrowska M., Kirnmel M., and Widlak P. TNF alpha-induced activation of NF kappa B protects against UV-induced apoptosis specifically in p53-proficient cells. Acta Biochim Polonica 55 (2008) 741-748
17. Chendil D.R., Anga R.S., Meigooni D., Sathishkumar S., and Ahmed M.M. Curcumin confers radiosensitizing effect in prostate cancer cell line PC-3. Oncogene 23 (2004) 1599-1607