Stereoselective total synthesis of a potent natural antifungal compound (6S)-5,6,dihydro-6-[(2R)-2-hydroxy-6-phenyl hexyl]-2H-pyran-2-one

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 22, 2009, Pages 6396-6398

  Das, Biswanath ^a   Laxminarayana, Keetha ^a   Krishnaiah, Martha ^a   Kumar, Duddukuri Nandan ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

6 Substituted 5,6 dihydro 2H pyran 2 one; Antifungal compound; Diastereoselective iodo cyclization; Ring closing metathesis; Total synthesis

Indexed keywords

(6) 5,6,DIHYDRO 6 [(2) 2 HYDROXY 6 PHENYL HEXYL] 2H PYRAN 2 ONE; ANTIFUNGAL AGENT; EPOXIDE; IODINE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ARTICLE; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; GRIGNARD REACTION; RING CLOSING METATHESIS; RING OPENING; STEREOCHEMISTRY;

ANTIFUNGAL AGENTS; CANDIDIASIS; CATALYSIS; CYCLIZATION; DRUG DESIGN; EPOXY COMPOUNDS; KINETICS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 71049142266     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.09.063     Document Type: Article

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