Inflammation in respiratory allergy treated by sublingual immunotherapy

European Journal of Inflammation

Volumn 7, Issue 3, 2009, Pages 121-129

  Frati, Franco ^a,b   Scurati, S ^b   Puccinelli, P ^b   Morviducci, C ^c   Cara, G D I ^a   Boccardo, R ^a   Piergentili, E ^a   Milioni, M ^a   Bernardini, R ^d   Sambugaro, R ^e   Castellano, F ^f   Varricchio, A ^g   Manfredi, G ^h   Cordero, L ⁱ   Russello, M ^j   Guercio, E ^k   Mauro, M ^j   Incorvaia, C ^l  

^a UNIVERSITY OF PERUGIA   (Italy)

^b Dipartimento Scientifico   (Italy)

^c Stallergenes   (Italy)

^d General Hospital   (Italy)

^e Pediatric National Health Service   (Italy)

^f General Hospital   (Italy)

^g SANTOBONO PAUSILIPON CHILDREN S HOSPITAL   (Italy)

^h MIULLI GENERAL HOSPITAL   (Italy)

ⁱ UNIVERSITY HOSPITAL OF SASSARI   (Italy)

^j SANT ANNA HOSPITAL   (Italy)

^k General Hospital   (Italy)

^l ICP Hospital   (Italy)

more..

Author keywords

Allergic inflammation; Cytokines; Dendritic cells; Oral biopsies; Sublingual immunotherapy; T cells

Indexed keywords

ALLERGEN; GAMMA INTERFERON; GRASS POLLEN EXTRACT; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; POLLEN EXTRACT; TRANSFORMING GROWTH FACTOR BETA;

ANTIBODY PRODUCTION; ANTIINFLAMMATORY ACTIVITY; ASTHMA; ATOPIC DERMATITIS; BIRCH; CLONAL ANERGY; DENDRITIC CELL; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG TOLERANCE; HOUSE DUST ALLERGY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INFLAMMATION; INFLAMMATORY CELL; PATHOPHYSIOLOGY; PHENOTYPE; REGULATORY T LYMPHOCYTE; RESPIRATORY TRACT ALLERGY; REVIEW; RHINITIS; T LYMPHOCYTE;

EID: 70949088575     PISSN: 1721727X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1721727x0900700301     Document Type: Review

References (48)

1. Adkinson NF, Yunginger JW, Busse WW, Bochner B, Simons FE, Holgate ST. Middleton's Allergy. Principles and Practice, Mosby: St. Louis, 2008.
2. Bousquet J, Lockey R, Mailing HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. Allergy 1998; 53(S):4-30.
3. Langlois RA, Legge KL. Respiratory dendritic cells: mediators of tolerance and immunity. Immunol Res 2007; 39:128-145 (Pubitemid 47574880)
4. Allam JP, Novak N, Fuchs C, Asen S, Bergé S, Appel T, Geiger E, Kochen JP, Bieber T. Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression. J Allergy Clin Immunol 2003; 112:141-148 (Pubitemid 36819819)
5. von Bubnoff D, Fimmers R, Bogdanow M, Matz H, Koch S, Bieber T. Asymptomatic atopy is associated with increased indoleamine 2,3-dioxygenase activity and interleukin-10 production during seasonal allergen exposure. Clin Exp Allergy 2004; 34:1056-63. (Pubitemid 38969541)
6. Larchè M, Robinson DS, Kay AB. The role of T lymphocytes in the pathogenesis of asthma J Allergy Clin Immunol 2003; 111:450-463
7. Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology 2006; 117:433-442
8. Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005; 116:961-968 (Pubitemid 41571773)
9. Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2006; 117:S450-56. (Pubitemid 43163457)
10. Schwartz LB. Mast cells and basophils. Clin Allergy Immunol 2002;16:3-42.
11. Norris A. Targeting mast cells. Expert Opin Invest Drugs 2004; 13:739-741
12. Rauter I, Krauth MT, Flickens S, et al. Allergen cleavage by effector cell-derived proteases regulates allergic inflammation. FASEB J 2006; 20:967-969
13. Thomas PS. Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 2001; 79:132-140
14. Penido C, Costa MF, Souza MC, Costa KA, Candea AL, Benjamin CF, Henriques MG. Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway. Int Immunol 2008; 20:129-39.
15. Schroeder JT, MacGlashan DW, Lichtenstein LM. Human basophils: mediator release and cytokine production. Adv Immunol 2001; 77:93-122. (Pubitemid 33703704)
16. Kita H, Adolphson C, Gleich G. In Clinical immunology. Principles and practice. Rich R, Fleisher T, Shearer W, eds. Mosby-Year Book: St Louis, 2001; p 356-371
17. Bochner BS. Systemic activation of basophils and eosinophils: markers and consequences. J Allergy Clin Immunol 2000; 106: S292-302.
18. Akdis CA. New insights into mechanisms of immunoregulation. J Allergy Clin Immunol 2008; 122:700-709
19. Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007; 119:780-791
20. Moingeon P, Batard T, Fadel R, Frati F, Sieber J, Overtvelt L. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy 2006; 61:151-165 (Pubitemid 43381824)
21. Incorvaia C, Frati F, Sensi L, Riario-Sforza GG, Marcucci F. Allergic inflammation and the oral mucosa. Rec Pat Inflammation Allergy Drug Discov 2007; 1:35-38.
22. Aoyama-Kondo T, Yoshida T, Tsobe K, Nakayama A, Asai J, Oka T, Nakashima I. Characterization of antibody responses of local lymph nodes to antigen given under the oral submucosa. Immunobiology 1992; 184:372-383
23. Allam JP, Peng WM, Appel T, Wenghofer M, Niederhagen B, Bieber T, Bergè S, Novak N. Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. J Allergy Clin Immunol 2008; 121:368-374 (Pubitemid 351215174)
24. Jutel M. Akdis M, Blaser K, Akdis CA. Mechanisms of allergen specific immunotherapy-T-cell tolerance and more. Allergy 2006; 61:796-807. (Pubitemid 43893981)
25. Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA. Mechanisms of immune suppression by interleukin-10 and transforming growth factor beta: the role of T regulatory cells. Immunology 2006; 117:433-442
26. McHugh RS, Shevah EM. The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002; 111:693-702. (Pubitemid 35423170)
27. Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, Akdis CA. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33:1205-1214 (Pubitemid 36609138)
28. Savolainen J, Laaksonen K, Rantio-Lehtimski G, Terho EO. Increased expression of allergen-induced in vitro interleukin-10 and interleukin-18 mRNA in peripheral blood mononuclear cells of allergic rhinitis patients after specific immunotherapy. Clin Exp Allergy 2004; 34:413-419 (Pubitemid 38373004)
29. Horner AA, van Uden JH, Zubeldia JM, Broide D, Raz E. DNA-based immunotherapeutics for the treatment of allergic disease. Immunol Rev 2001; 179:102-118 (Pubitemid 32171278)
30. Bohle B, Kinaciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C. Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol 2007; 120:707-713 (Pubitemid 47320765)
31. Okamura H, Tsutsui H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995; 6552:88-91.
32. Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE, Nakanishi K. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci USA 1999; 96:13962-13966
33. Savolainen J, Nieminen K, Laaksonen K, Laiho T, Jacobsen L, Lahesmaa R, Terho EO, Valovirta P. Allergen-induced in vitro expression of IL-18, SLAM and GATA-3 mRNA in PBMC during sublingual immunotherapy. Allergy 2007; 62:949-953
34. Ciprandi G, Fenoglio D, Di Gioacchino M, Ferrera A, Ferrera F, Soriani MP, Marseglia GL. Sublingual immunotherapy provides an early increase of interferon-gamma production. J Biol Regul Homeost Agents 2008; 22:169-173
35. Bousquet J, van Cauwenberge P, Khaltaev N; Aria Workshop Group; World Health Organization. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001; 108(S):147-334.
36. Wilson DR, Torres Lima M, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy 2005; 60:4-12.
37. Didier A, Mailing HJ, Worm M, Horak F, Jager S, Montagut A, Andrè C, de Beaumont O, Melac M. Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis. J Allergy Clin Immunol 2007; 120:1338-1345 (Pubitemid 350225683)
38. Mailing HJ, Lund L, Ipsen H, Poulsen L. Safety and immunological changes during sublingual immunotherapy with standardized quality grass allergen tablets. J Invest Allergol Clin Immunol 2006; 16;162-168 (Pubitemid 43911057)
39. Bahceciler N, Arikan C, Taylor A, Akdis M, Blaser K, Barlan I, Akdis C. Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol 2005; 136:287-294 (Pubitemid 40529201)
40. van Neerven RJ, Arvidsson M, Ipsen H, Sparholt SH, Rak S, Würtzen PA. A double-blind, placebo-controlled birch allergy vaccination study: inhibition of CD23-mediated serum-immunoglobulin E-facilitated allergen presentation. Clin Exp Allergy 2004; 34:420-428 (Pubitemid 38373005)
41. Naclerio RM, Meier HL, Kagey-Sobotka A, Adkinson NF, Meyers DA, Norman PS, Lichtenstein LM. Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis 1983; 128:597-602.
42. Pierkes M, Bellinghausen I, Hultsch T, Metz G, Knop J, Saloga J. Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. J Allergy Clin Immunol 1999; 103:326-332 (Pubitemid 29095840)
43. Marshall JS, Leal-Berumen I, Nielsen L, Glibetic M, Jordana M. Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells. J Clin Invest 1996; 97: 1122-1128 (Pubitemid 26070592)
44. Rak S, Lowhagen O, Venge P. The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients. J Allergy Clin Immunol 1988; 82:470-480 (Pubitemid 18238316)
45. Marcucci F, Sensi L, Frati F, Senna GE, Canonica GW, Parmiani S, Passalacqua G. Sublingual tryptase and ECP in children treated with grass pollen sublingual immunotherapy (SLIT): safety and immunologic implications. Allergy 2001; 56:1091-1095 (Pubitemid 33020652)
46. Passalacqua G, Albano M, Riccio A, Fregonese L, Puccinelli P, Parmiani S, Canonica GW. Clinical and immunologic effects of a rush sublingual immunotherapy to Parietaria species: A double-blind, placebo-controlled trial. J Allergy Clin Immunol 1999; 104:964-968 (Pubitemid 29532116)
47. Marcucci F, Incorvaia C, Sensi L, et al. Lack of inflammatory cells in the oral mucosa of subjects undergoing sublingual immunotherapy. Int J Immunopathol Pharmacol 2008: 21:609-613
48. Joos GF, Brusselle GG, Van Hoecke H, Van Cauwenberge P, Bousquet J, Pauwels RA. Positioning of glucocorticosteroids in asthma and allergic rhinitis guidelines (versus other therapies). Immunol Allergy Clin N Am 2005; 25:597-612. (Pubitemid 41073464)