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Volumn 49, Issue 2, 2010, Pages 1259-1270

Study on the neuroprotective effect of fluoxetine against MDMA-induced neurotoxicity on the serotonin transporter in rat brain using micro-PET

Author keywords

3,4 Methylenedioxymethamphetamine; 4 18F ADAM; Fluoxetine; Immunohistochemistry; Positron emission tomography; Serotonin transporter

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; FLUOXETINE; N,N DIMETHYL 2 (2 AMINO 4 FLUOROPHENYLTHIO)BENZYLAMINE F 18; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

EID: 70949084498     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2009.07.072     Document Type: Article
Times cited : (47)

References (71)
  • 1
    • 12444281751 scopus 로고    scopus 로고
    • Neurobiologic processes in drug reward and addiction
    • Adinoff B. Neurobiologic processes in drug reward and addiction. Harv. Rev. Psychiatry 12 (2004) 305-320
    • (2004) Harv. Rev. Psychiatry , vol.12 , pp. 305-320
    • Adinoff, B.1
  • 2
    • 20444379646 scopus 로고    scopus 로고
    • Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's disease
    • Andringa G., Drukarch B., Bol J.G., de Bruin K., Sorman K., Habraken J.B., and Booij J. Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's disease. NeuroImage 26 (2005) 1150-1158
    • (2005) NeuroImage , vol.26 , pp. 1150-1158
    • Andringa, G.1    Drukarch, B.2    Bol, J.G.3    de Bruin, K.4    Sorman, K.5    Habraken, J.B.6    Booij, J.7
  • 3
    • 10444238563 scopus 로고    scopus 로고
    • Drug abuse trends among youth in the United States
    • Banken J.A. Drug abuse trends among youth in the United States. Ann. N. Y. Acad. Sci. 1025 (2004) 465-471
    • (2004) Ann. N. Y. Acad. Sci. , vol.1025 , pp. 465-471
    • Banken, J.A.1
  • 4
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons
    • Battaglia G., Yeh S.Y., and De Souza E.B. MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. Pharmacol. Biochem. Behav. 29 (1988) 269-274
    • (1988) Pharmacol. Biochem. Behav. , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    De Souza, E.B.3
  • 5
    • 33751230490 scopus 로고    scopus 로고
    • 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings
    • Baumann M.H., Wang X., and Rothman R.B. 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings. Psychopharmacology (Berl.) 189 (2007) 407-424
    • (2007) Psychopharmacology (Berl.) , vol.189 , pp. 407-424
    • Baumann, M.H.1    Wang, X.2    Rothman, R.B.3
  • 6
    • 0026534558 scopus 로고
    • The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine
    • Berger U.V., Gu X.F., and Azmitia E.C. The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. Eur. J. Pharmacol. 215 (1992) 153-160
    • (1992) Eur. J. Pharmacol. , vol.215 , pp. 153-160
    • Berger, U.V.1    Gu, X.F.2    Azmitia, E.C.3
  • 7
    • 0038741972 scopus 로고    scopus 로고
    • Short- and long-term effects of MDMA ("ecstasy") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo
    • Bogen I.L., Haug K.H., Myhre O., and Fonnum F. Short- and long-term effects of MDMA ("ecstasy") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo. Neurochem. Int. 43 (2003) 393-400
    • (2003) Neurochem. Int. , vol.43 , pp. 393-400
    • Bogen, I.L.1    Haug, K.H.2    Myhre, O.3    Fonnum, F.4
  • 10
    • 0025268525 scopus 로고
    • Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat
    • Caccia S., Cappi M., Fracasso C., and Garattini S. Influence of dose and route of administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat. Psychopharmacology (Berl.) 100 (1990) 509-514
    • (1990) Psychopharmacology (Berl.) , vol.100 , pp. 509-514
    • Caccia, S.1    Cappi, M.2    Fracasso, C.3    Garattini, S.4
  • 11
    • 0030986255 scopus 로고    scopus 로고
    • In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine
    • Colado M.I., O'Shea E., Granados R., Murray T.K., and Green A.R. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. Br. J. Pharmacol. 121 (1997) 889-900
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 889-900
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Murray, T.K.4    Green, A.R.5
  • 12
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins D.L., Vosmer G., Virus R.M., Woolverton W.L., Schuster C.R., and Seiden L.S. Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain. J. Pharmacol. Exp. Ther. 241 (1987) 338-345
    • (1987) J. Pharmacol. Exp. Ther. , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.M.3    Woolverton, W.L.4    Schuster, C.R.5    Seiden, L.S.6
  • 13
    • 0026787192 scopus 로고
    • The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes
    • Crewe H.K., Lennard M.S., Tucker G.T., Woods F.R., and Haddock R.E. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br. J. Clin. Pharmacol. 34 (1992) 262-265
    • (1992) Br. J. Clin. Pharmacol. , vol.34 , pp. 262-265
    • Crewe, H.K.1    Lennard, M.S.2    Tucker, G.T.3    Woods, F.R.4    Haddock, R.E.5
  • 15
    • 4544314351 scopus 로고    scopus 로고
    • Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans
    • de la Torre R., and Farre M. Neurotoxicity of MDMA (ecstasy): the limitations of scaling from animals to humans. Trends Pharmacol. Sci. 25 (2004) 505-508
    • (2004) Trends Pharmacol. Sci. , vol.25 , pp. 505-508
    • de la Torre, R.1    Farre, M.2
  • 18
    • 0029125154 scopus 로고
    • Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
    • Fischer C., Hatzidimitriou G., Wlos J., Katz J., and Ricaurte G. Reorganization of ascending 5-HT axon projections in animals previously exposed to the recreational drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). J .Neurosci. 15 (1995) 5476-5485
    • (1995) J .Neurosci. , vol.15 , pp. 5476-5485
    • Fischer, C.1    Hatzidimitriou, G.2    Wlos, J.3    Katz, J.4    Ricaurte, G.5
  • 19
    • 0037289543 scopus 로고    scopus 로고
    • 11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats
    • 11C]-DASB, a tool for in vivo measurement of SSRI-induced occupancy of the serotonin transporter: PET characterization and evaluation in cats. Synapse 47 (2003) 123-133
    • (2003) Synapse , vol.47 , pp. 123-133
    • Ginovart, N.1    Wilson, A.A.2    Meyer, J.H.3    Hussey, D.4    Houle, S.5
  • 20
    • 0025950754 scopus 로고
    • Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate
    • Gough B., Ali S.F., Slikker Jr. W., and Holson R.R. Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. Pharmacol. Biochem. Behav. 39 (1991) 619-623
    • (1991) Pharmacol. Biochem. Behav. , vol.39 , pp. 619-623
    • Gough, B.1    Ali, S.F.2    Slikker Jr., W.3    Holson, R.R.4
  • 21
    • 0041466261 scopus 로고    scopus 로고
    • The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
    • Green A.R., Mechan A.O., Elliott J.M., O'Shea E., and Colado M.I. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol. Rev. 55 (2003) 463-508
    • (2003) Pharmacol. Rev. , vol.55 , pp. 463-508
    • Green, A.R.1    Mechan, A.O.2    Elliott, J.M.3    O'Shea, E.4    Colado, M.I.5
  • 22
    • 0036297032 scopus 로고    scopus 로고
    • Positron emission tomography and brain monoamine neurotransmission - entries for study of drug interactions
    • Hartvig P., Bergström M., Antoni G., and Langstrom B. Positron emission tomography and brain monoamine neurotransmission - entries for study of drug interactions. Curr. Pharm. Des. 8 (2002) 1417-1434
    • (2002) Curr. Pharm. Des. , vol.8 , pp. 1417-1434
    • Hartvig, P.1    Bergström, M.2    Antoni, G.3    Langstrom, B.4
  • 23
    • 0033564773 scopus 로고    scopus 로고
    • Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery
    • Hatzidimitriou G., McCann U.D., and Ricaurte G.A. Altered serotonin innervation patterns in the forebrain of monkeys treated with (+/-)3,4-methylenedioxymethamphetamine seven years previously: factors influencing abnormal recovery. J. Neurosci. 19 (1999) 5096-5107
    • (1999) J. Neurosci. , vol.19 , pp. 5096-5107
    • Hatzidimitriou, G.1    McCann, U.D.2    Ricaurte, G.A.3
  • 24
    • 0026680529 scopus 로고
    • Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy")
    • Henry J.A., Jeffreys K.J., and Dawling S. Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("ecstasy"). Lancet 340 (1992) 384-387
    • (1992) Lancet , vol.340 , pp. 384-387
    • Henry, J.A.1    Jeffreys, K.J.2    Dawling, S.3
  • 25
    • 7444220628 scopus 로고    scopus 로고
    • Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    • Hesse S., Barthel H., Schwarz J., Sabri O., and Müller U. Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders. Neurosci. Biobehav. Rev. 28 (2004) 547-563
    • (2004) Neurosci. Biobehav. Rev. , vol.28 , pp. 547-563
    • Hesse, S.1    Barthel, H.2    Schwarz, J.3    Sabri, O.4    Müller, U.5
  • 26
    • 4043093487 scopus 로고    scopus 로고
    • 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B
    • Hrometz S.L., Brown A.W., Nichols D.E., and Sprague J.E. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neurosci. Lett. 367 (2004) 56-59
    • (2004) Neurosci. Lett. , vol.367 , pp. 56-59
    • Hrometz, S.L.1    Brown, A.W.2    Nichols, D.E.3    Sprague, J.E.4
  • 28
    • 13844317450 scopus 로고    scopus 로고
    • Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?
    • Kish S.J., Furukawa Y., Chang L.J., Tong J., Ginovart N., Wilson A., Houle S., and Meyer J.H. Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region?. Nucl. Med. Biol. 32 (2005) 123-128
    • (2005) Nucl. Med. Biol. , vol.32 , pp. 123-128
    • Kish, S.J.1    Furukawa, Y.2    Chang, L.J.3    Tong, J.4    Ginovart, N.5    Wilson, A.6    Houle, S.7    Meyer, J.H.8
  • 30
    • 0033593604 scopus 로고    scopus 로고
    • Detection of fluoxetine in brain, blood, liver and hair of rats using gas chromatography-mass spectrometry
    • Lefebvre M., Marchand M., Horowitz J.M., and Torres G. Detection of fluoxetine in brain, blood, liver and hair of rats using gas chromatography-mass spectrometry. Life Sci. 64 (1999) 805-811
    • (1999) Life Sci. , vol.64 , pp. 805-811
    • Lefebvre, M.1    Marchand, M.2    Horowitz, J.M.3    Torres, G.4
  • 32
    • 0028827808 scopus 로고
    • Serotonin depletion decreases serotonin transporter mRNA levels in rat brain
    • Linnet K., Koed K., Wiborg O., and Gregersen N. Serotonin depletion decreases serotonin transporter mRNA levels in rat brain. Brain Res. 697 (1995) 251-253
    • (1995) Brain Res. , vol.697 , pp. 251-253
    • Linnet, K.1    Koed, K.2    Wiborg, O.3    Gregersen, N.4
  • 35
    • 0034653801 scopus 로고    scopus 로고
    • Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy')
    • Maurer H.H., Bickeboeller-Friedrich J., Kraemer T., and Peters F.T. Toxicokinetics and analytical toxicology of amphetamine-derived designer drugs ('Ecstasy'). Toxicol. Lett. 112-113 (2000) 133-142
    • (2000) Toxicol. Lett. , vol.112-113 , pp. 133-142
    • Maurer, H.H.1    Bickeboeller-Friedrich, J.2    Kraemer, T.3    Peters, F.T.4
  • 36
    • 0032585201 scopus 로고    scopus 로고
    • Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings
    • McCann U.D., Szabo Z., Scheffel U., Dannals R.F., and Ricaurte G.A. Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. Lancet 352 (1998) 1433-1437
    • (1998) Lancet , vol.352 , pp. 1433-1437
    • McCann, U.D.1    Szabo, Z.2    Scheffel, U.3    Dannals, R.F.4    Ricaurte, G.A.5
  • 38
    • 0034780661 scopus 로고    scopus 로고
    • Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants
    • Mortensen O.V., Kristensen A.S., and Wiborg O. Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants. J. Neurochem. 79 (2001) 237-247
    • (2001) J. Neurochem. , vol.79 , pp. 237-247
    • Mortensen, O.V.1    Kristensen, A.S.2    Wiborg, O.3
  • 40
    • 33144455536 scopus 로고    scopus 로고
    • Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin
    • Nielsen K., Brask D., Knudsen G.M., and Aznar S. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse 59 (2006) 270-276
    • (2006) Synapse , vol.59 , pp. 270-276
    • Nielsen, K.1    Brask, D.2    Knudsen, G.M.3    Aznar, S.4
  • 41
    • 0035052951 scopus 로고    scopus 로고
    • Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate
    • Nixdorf W.L., Burrows K.B., Gudelsky G.A., and Yamamoto B.K. Enhancement of 3,4-methylenedioxymethamphetamine neurotoxicity by the energy inhibitor malonate. J. Neurochem. 77 (2001) 647-654
    • (2001) J. Neurochem. , vol.77 , pp. 647-654
    • Nixdorf, W.L.1    Burrows, K.B.2    Gudelsky, G.A.3    Yamamoto, B.K.4
  • 42
    • 0346639257 scopus 로고    scopus 로고
    • Ecstasy: pharmacodynamic and pharmacokinetic interactions
    • Oesterheld J.R., Armstrong S.C., and Cozza K.L. Ecstasy: pharmacodynamic and pharmacokinetic interactions. Psychosomatics 45 (2004) 84-87
    • (2004) Psychosomatics , vol.45 , pp. 84-87
    • Oesterheld, J.R.1    Armstrong, S.C.2    Cozza, K.L.3
  • 43
    • 8344259984 scopus 로고    scopus 로고
    • MDMA (3,4-Methylenedioxymethamphetamine) or ecstasy: the neuropsychobiological implications of taking it at dances and raves
    • Parrott A.C. MDMA (3,4-Methylenedioxymethamphetamine) or ecstasy: the neuropsychobiological implications of taking it at dances and raves. Neuropsychobiology 50 (2004) 329-335
    • (2004) Neuropsychobiology , vol.50 , pp. 329-335
    • Parrott, A.C.1
  • 46
    • 40549088916 scopus 로고    scopus 로고
    • Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram
    • Piper B.J., Fraiman J.B., Owens C.B., Ali S.F., and Meyer J.S. Dissociation of the neurochemical and behavioral toxicology of MDMA ('Ecstasy') by citalopram. Neuropsychopharmacology 33 (2008) 1192-1205
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1192-1205
    • Piper, B.J.1    Fraiman, J.B.2    Owens, C.B.3    Ali, S.F.4    Meyer, J.S.5
  • 47
    • 0033618638 scopus 로고    scopus 로고
    • Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants
    • Ramamoorthy S., and Blakely R.D. Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants. Science 285 (1999) 763-766
    • (1999) Science , vol.285 , pp. 763-766
    • Ramamoorthy, S.1    Blakely, R.D.2
  • 49
    • 33746825174 scopus 로고    scopus 로고
    • Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects
    • Reneman L., de Win M.M., van den Brink W., Booij J., and den Heeten G.J. Neuroimaging findings with MDMA/ecstasy: technical aspects, conceptual issues and future prospects. J. Psychopharmacol. 20 (2006) 164-175
    • (2006) J. Psychopharmacol. , vol.20 , pp. 164-175
    • Reneman, L.1    de Win, M.M.2    van den Brink, W.3    Booij, J.4    den Heeten, G.J.5
  • 50
    • 0026546876 scopus 로고
    • The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release
    • Rudnick G., and Wall S.C. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 1817-1821
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 1817-1821
    • Rudnick, G.1    Wall, S.C.2
  • 51
    • 0034852341 scopus 로고    scopus 로고
    • The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain
    • Sanchez V., Camarero J., Esteban B., Peter M.J., Green A.R., and Colado M.I. The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. Br. J. Pharmacol. 134 (2001) 46-57
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 46-57
    • Sanchez, V.1    Camarero, J.2    Esteban, B.3    Peter, M.J.4    Green, A.R.5    Colado, M.I.6
  • 52
    • 0032981063 scopus 로고    scopus 로고
    • Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding
    • Sánchez C., and Hyttel J. Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell. Mol. Neurobiol. 19 (1999) 467-489
    • (1999) Cell. Mol. Neurobiol. , vol.19 , pp. 467-489
    • Sánchez, C.1    Hyttel, J.2
  • 54
    • 0025180948 scopus 로고
    • Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand?
    • Scheffel U., and Ricaurte G.A. Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand?. Brain Res. 527 (1990) 89-95
    • (1990) Brain Res. , vol.527 , pp. 89-95
    • Scheffel, U.1    Ricaurte, G.A.2
  • 55
    • 0031945694 scopus 로고    scopus 로고
    • In vivo detection of short- and long-term MDMA neurotoxicity-a positron emission tomography study in the living baboon brain
    • Scheffel U., Szabo Z., Mathews W.B., Finley P.A., Dannals R.F., Ravert H.T., Szabo K., Yuan J., and Ricaurte G.A. In vivo detection of short- and long-term MDMA neurotoxicity-a positron emission tomography study in the living baboon brain. Synapse 29 (1998) 183-192
    • (1998) Synapse , vol.29 , pp. 183-192
    • Scheffel, U.1    Szabo, Z.2    Mathews, W.B.3    Finley, P.A.4    Dannals, R.F.5    Ravert, H.T.6    Szabo, K.7    Yuan, J.8    Ricaurte, G.A.9
  • 56
    • 2542629618 scopus 로고    scopus 로고
    • A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities
    • Schifano F. A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities. Psychopharmacology (Berl.) 173 (2004) 242-248
    • (2004) Psychopharmacology (Berl.) , vol.173 , pp. 242-248
    • Schifano, F.1
  • 57
    • 0023163857 scopus 로고
    • Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
    • Schmidt C.J. Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J. Pharmacol. Exp. Ther. 240 (1987) 1-7
    • (1987) J. Pharmacol. Exp. Ther. , vol.240 , pp. 1-7
    • Schmidt, C.J.1
  • 58
    • 0032985047 scopus 로고    scopus 로고
    • Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users
    • Semple D.M., Ebmeier K.P., Glabus M.F., O'Carroll R.E., and Johnstone E.C. Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users. Br. J. Psychiatry 175 (1999) 63-69
    • (1999) Br. J. Psychiatry , vol.175 , pp. 63-69
    • Semple, D.M.1    Ebmeier, K.P.2    Glabus, M.F.3    O'Carroll, R.E.4    Johnstone, E.C.5
  • 59
    • 0033986934 scopus 로고    scopus 로고
    • A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration
    • Shankaran M., and Gudelsky G.A. A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology (Berl.) 147 (1999) 66-72
    • (1999) Psychopharmacology (Berl.) , vol.147 , pp. 66-72
    • Shankaran, M.1    Gudelsky, G.A.2
  • 60
    • 0032763755 scopus 로고    scopus 로고
    • Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine
    • Shankaran M., Yamamoto B.K., and Gudelsky G.A. Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. Eur. J. Pharmacol. 385 (1999) 103-110
    • (1999) Eur. J. Pharmacol. , vol.385 , pp. 103-110
    • Shankaran, M.1    Yamamoto, B.K.2    Gudelsky, G.A.3
  • 62
    • 0037314599 scopus 로고    scopus 로고
    • 18F]fluorophenylthio)benzylamine as a serotonin transporter imaging agent
    • 18F]fluorophenylthio)benzylamine as a serotonin transporter imaging agent. Appl. Radiat. Isot. 58 (2003) 183-191
    • (2003) Appl. Radiat. Isot. , vol.58 , pp. 183-191
    • Shiue, G.G.1    Fang, P.2    Shiue, C.Y.3
  • 63
    • 0031749512 scopus 로고    scopus 로고
    • An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine
    • Sprague J.E., Everman S.L., and Nichols D.E. An integrated hypothesis for the serotonergic axonal loss induced by 3,4-methylenedioxymethamphetamine. Neurotoxicology 19 (1998) 427-441
    • (1998) Neurotoxicology , vol.19 , pp. 427-441
    • Sprague, J.E.1    Everman, S.L.2    Nichols, D.E.3
  • 64
    • 0029904206 scopus 로고    scopus 로고
    • Immunocytochemical detection of the serotonin transporter in rat brain
    • Sur C., Betz H., and Schloss P. Immunocytochemical detection of the serotonin transporter in rat brain. Neuroscience 73 (1996) 217-231
    • (1996) Neuroscience , vol.73 , pp. 217-231
    • Sur, C.1    Betz, H.2    Schloss, P.3
  • 66
    • 34548149262 scopus 로고    scopus 로고
    • 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice
    • Trigo J.M., Renoir T., Lanfumey L., Hamon M., Lesch K.P., Robledo P., and Maldonado R. 3,4-methylenedioxymethamphetamine self-administration is abolished in serotonin transporter knockout mice. Biol. Psychiatry 62 (2007) 669-679
    • (2007) Biol. Psychiatry , vol.62 , pp. 669-679
    • Trigo, J.M.1    Renoir, T.2    Lanfumey, L.3    Hamon, M.4    Lesch, K.P.5    Robledo, P.6    Maldonado, R.7
  • 68
    • 43249126070 scopus 로고    scopus 로고
    • Fluoxetine pretreatment effects pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, ECSTASY) in rat
    • Upreti V.V., and Eddington N.D. Fluoxetine pretreatment effects pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, ECSTASY) in rat. J. Pharm. Sci. 97 (2008) 1593-1605
    • (2008) J. Pharm. Sci. , vol.97 , pp. 1593-1605
    • Upreti, V.V.1    Eddington, N.D.2
  • 69
    • 33751237085 scopus 로고    scopus 로고
    • MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment
    • Verrico C.D., Miller G.M., and Madras B.K. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl.) 189 (2007) 489-503
    • (2007) Psychopharmacology (Berl.) , vol.189 , pp. 489-503
    • Verrico, C.D.1    Miller, G.M.2    Madras, B.K.3
  • 71
    • 0032517176 scopus 로고    scopus 로고
    • Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence
    • Zhou F.C., Tao-Cheng J.H., Segu L., Patel T., and Wang Y. Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence. Brain Res. 805 (1998) 241-254
    • (1998) Brain Res. , vol.805 , pp. 241-254
    • Zhou, F.C.1    Tao-Cheng, J.H.2    Segu, L.3    Patel, T.4    Wang, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.