Baicalein induces programmed cell death in Candida albicans

Journal of Microbiology and Biotechnology

Volumn 19, Issue 8, 2009, Pages 803-809

  Dai, Bao Di ^a,b   Cao, Ying Ying ^a   Huang, Shan ^a   Xu, Yong Gang ^a   Gao, Ping Hui ^a   Wang, Yan ^a   Jiang, Yuan Ying ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Baicalein; Candida albicans; Mitochondrial membrane potential; Programmed cell death

Indexed keywords

AMPHOTERICIN B; BAICALEIN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; PROTEIN CAP1P; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DELETION MUTANT; DRUG SCREENING; FLOW CYTOMETRY; FUNGAL CELL; FUNGAL VIABILITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

ANTIOXIDANTS; APOPTOSIS; CANDIDA ALBICANS; CANDIDIASIS; CELL CYCLE PROTEINS; FLAVANONES; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; REACTIVE OXYGEN SPECIES; RNA, FUNGAL; UP-REGULATION;

CANDIDA ALBICANS;

EID: 70849132810     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.0812.662     Document Type: Article

References (37)

1. Alarco, A. M. and M. Raymond. 1999. The b-Zip transcription factor Cap1p is involved in multiple resistance and oxidative stress response in Candida albicans. J. Bacteriol. 181: 700-708.
2. Almeida, T., M. Marques, D. Mojzita, M. A. Amorim, R. D. Silva, B. Almeida, et al. 2008. Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis. Mol. Biol. Cell 19: 865-876.
3. Baek, Y. U., Y. R. Kim, H. S. Yim, and S. O. Kang. 2004. Disruption of γ-glutamylcysteine synthetase results in absolute glutathione auxotrophy and apoptosis in Candida albicans. FEBS Lett. 556: 47-52.
4. Braun, R. J., H. Zischka, F. Madeo, T. Eisenberg, S. Wissing, S. Buttner, S. M. Engelhard, D. Büringer, and M. Ueffing. 2006. Crucial mitochondrial impairment upon CDC48 mutation apoptotic yeast. J. Biol. Chem. 281: 25757-25767.
5. Cao, Y. Y., B. D. Dai, Y. Wang, S. Huang, Y. G. Xu, Y. B. Cao, P. H. Gao, Z. Y. Zhu, and Y. Y. Jiang. 2008. In vitro activity of baicalein against Candida albicans biofilms. Int. J. Antimicrob. Agents 32: 73-77.
6. Cao, Y. Y., Y. Wang, B. D. Dai, B. Wang, H. Zhang, Z. Y. Zhu, et al. 2008. Trehalose is an important mediator of Cap1p oxidative stress response in Candida albicans. Biol. Pharm. Bull. 31: 421-425.
7. Carmel-Hare, O. and G. Storz. 2000. Roles of the glutathioneand thioredoxin-dependent reduction systems in the Escherichia coli and Saccharomyces cerevisiae responses to oxidative stress. Annu. Rev. Microbiol. 54: 439-461.
8. Chang, P. C., H. Y. Li, H. J. Tang, J. W. Liu, J. J. Wang, and Y. C. Chuang. 2007. In vitro synergy of baicalein and gentamicin against vancomycin-resistant Enterococcus. J. Microbiol. Immunol. Infect. 40: 56-61.
9. Chang, W. T., Z. H. Shao, J. J. Yin, S. Mehendale, C. Z. Wang, Y. Qin, et al. 2007. Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. Eur. J. Pharmacol. 566: 58-66.
10. Chiou, C. C., A. H. Groll, and T. J. Walsh. 2000. New drugs and novel targets for treatment of invasive fungal infections in patients with cancer. Oncologist 5: 120-122.
11. Cowen, L. E., J. B. Anderson, and L. M. Kohn. 2002. Evolution of drug resistance in Candida albicans. Annu. Rev. Microbiol. 56: 139-165.
12. Fonzi, W. A. and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134: 717-728.
13. Garber, G. 2001. An overview of fungal infections. Drugs 61 (Suppl.1): 1-12.
14. Grant, C. M. 2001. Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol. Microbiol. 39: 533-541.
15. Guaragnella, N., C. Pereira, M. J. Sousa, L. Antonacci, S. Passarella, M. Côrte-Real, and E. Marra. 2006. YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity. FEBS Lett. 580: 6880-6884.
16. Ishige, K., D. Schubert, and Y. Sagara. 2001. Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic. Biol. Med. 29: 433-446.
17. Lapchak, P. A., P. Maher, D. Schubert, and J. A. Zivin. 2007. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor, improves clinical rating scores following multiple infarct embolic strokes. Neuroscience 150: 585-591.
18. Lin, H. Y., S. C. Shen, C. W. Lin, L. Y. Yang, and Y. C. Chen. 2007. Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression. Biochim. Biophys. Acta 1773: 1073-1086.
19. 2+-dependent mitochondrial pathway. In Vivo 21: 1053-1058.
20. Ludovico, P., F. Rodrigues, A. Almeida, M. T. Silva, A. Barrientos, and M. Corte-Real. 2002. Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol. Biol. Cell 13: 2598-2606.
21. Luk, E., M. Yang, L. T. Jensen, Y. Bourbonnais, and V. C. Culotta. 2005. Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae. J. Biol. Chem. 280: 22715-22720.
22. Maertens, J., M. Vrebos, and M. Boogaerts. 2001. Assessing risk factors for systemic fungal infections. Eur. J. Cancer Care (Engl) 10: 56-62.
23. Mazzoni, C., E. Herker, V. Palermo, H. Jungwirth, T. Eisenberg, F. Madeo, and C. Falcone. 2005. Yeast caspase 1 links messenger RNA stability to apoptosis in yeast. EMBO Rep. 6: 1076-1081.
24. Ono, K., H. Nakane, M. Fukushima, J. C. Chermann, and F. Barre-Sinoussi. 1990. Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerase. Eur. J. Biochem. 5: 469-476.
25. Phillips, A. J., J. D. Crowe, and M. Ramsdale. 2006. Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans. Proc. Natl. Acad. Sci. U.S.A. 103: 726-731.
26. Phillips, A. J., I. Sudbery, and M. Ramsdale. 2003. Apoptosis induced by environmental stresses and amphotericin B in Candida albicans. Proc. Natl. Acad. Sci. U.S.A. 100: 14327-14332.
27. Pozniakovsky, A. I., D. A. Knorre, O. V. Markova, A. A. Hyman, V. P. Skulachev, and F. F. Severin. 2005. Role of mitochondria in the pheromone- and amiodarone-induced programmed cell death of yeast. J. Cell Biol. 168: 257-269.
28. Trotter, E. W. and C. M. Grant. 2003. Non-reciprocal regulation of the redox status of the glutathione-glutaredoxin and thioredoxin systems. EMBO Rep. 4: 184-188.
29. Tu, I. H., H. T. David Yen, H. W. Cheng, and J. H. Chiu. 2008. Baicalein protects chicken embryonic cardiomyocyte against hypoxia-reoxygenation injury via μ- and δ- but not κ-opioid receptor signaling. Eur. J. Pharmacol. 58: 251-258
30. Tyler, D. D. 1975. Polarographic assay and intracellular distribution of superoxide dismutase in rat liver. Biochem. J. 147: 493-504.
31. van Leyen, K., H. Y. Kim, S. R. Lee, G. Jin, K. Arai, and E. H. Lo. 2006. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke 37: 3014-3018.
32. Wang, Y., Y. Y. Cao, Y. B. Cao, D. J. Wang, X. M. Jia, X. P. Fu, et al. 2007. Cap1p plays regulation roles in redox, energy metabolism and substance transport: An investigation on Candida albicans under normal culture condition. Front. Biosci. 12: 145-153.
33. Wang, Y., Y. Y. Cao, X. M. Jia, Y. B. Cao, P. H. Gao, X. P. Fu, K. Ying, W. S. Chen, and Y. Y. Jiang. 2006. Cap1p is involved in multiple pathways of oxidative stress response in Candida albicans. Free Radic. Biol. Med. 40: 1201-1209.
34. Wissing, S., P. Ludovico, E. Herker, S. Büttner, S. M. Engelhardt, T. Decker, et al. 2004. An AIF orthologue regulates apoptosis in yeast. J. Cell Biol. 166: 969-974.
35. Wu, J. A., A. S. Attele, L. Zhang, and C. S. Yuan. 2001. Anti- HIV activity of medinal herbs: Usage and potential development. Am. J. Chin. Med. 29: 69-81.
36. Yang, D., H. Hu, and S. Huang. 2000. Study on the inhibitory activity, in vitro, of baicalein and baicalin against skin fungi and bacteria. Zhong Yao Cai 23: 272-274.
37. Zhang, X., M. De Micheli, S. T. Coleman, D. Sanglard, and W. S. Moye-Rowley. 2000. Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p. Mol. Microbiol. 36: 618-629.